Results 61 to 70 of about 1,431 (182)

Angiopoietin‐like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride‐rich lipoproteins in humans

Journal of Internal Medicine, EarlyView.
Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Marcello Arca, Elias Björnson, Laura D'Erasmo, Alessia Di Costanzo, Simone Bini, Ilenia Minicocci, Daniele Tramontano, Stella Covino, Giuseppe Ciarlo, Manuela Lombardi, Sanni Söderlund, Niina Matikainen, Linda Andersson, Martin Adiels, Marja‐Riitta Taskinen, Chris J. Packard, Jan Borén   +16 more
wiley   +1 more source

A Subset of Pro‐inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin, Jovanne Palvair, Lennie Messager, Jamal Bamoulid, Jasper Callemeyn, Mélanie Chaintreuil, Ludivine Dal Zuffo, Didier Ducloux, Imane Farhat, Mathieu Legendre, Laurent Martin, Florian Renosi, Xavier Roussel, Thibaut Vaulet, Maarten Naesens, Claire Tinel, Baptiste Lamarthée   +16 more
wiley   +1 more source

ANGPTL8 level obese vs. non-obese.

, 2016
A: Level of full length form of ANGPTL8 in non-obese vs. obese subjects in circulation. B: Level of C-terminal 139–198 form of ANGPTL8 in non-obese vs. obese subjects in circulation.
Mohamed Abu-Farha (25322), Devarajan Sriraman (774093), Irina AlKhairi (846347), Preethi Cherian (437070), Kazem Behbehani (412126), Jehad Abubaker (437067), Naser Elkum (79418)   +6 more
core   +1 more source

Table1_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.docx

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source

Association of Serum Angiopoietin-Like Protein 8 With Albuminuria in Type 2 Diabetic Patients: Results From the GDMD Study in China

Frontiers in Endocrinology, 2018
Background: Hyperglycemia, insulin resistance and hypertriglyceridesmia are risk factors for albuminuria in type 2 diabetes. Angiopoietin-like Protein 8(ANGPTL8) is a newly identified liver-derived hormone related to these risk factors.
Liuxue Yang, Jianfei Song, Xiaoxi Zhang, Liuping Xiao, Xueping Hu, Haidong Pan, Linyuan Qin, Hongbo Liu, Bo Ge, Tianpeng Zheng, Tianpeng Zheng   +10 more
doaj   +1 more source

Image6_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.JPEG

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source

LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis

Nature Communications, 2023
Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog receptor, leukocyte immunoglobulin-like receptor B (
Dan-Pei Li, Li Huang, Ran-Ran Kan, Xiao-Yu Meng, Shu-Yun Wang, Hua-Jie Zou, Ya-Ming Guo, Pei-Qiong Luo, Li-Meng Pan, Yu-Xi Xiang, Bei-Bei Mao, Yu-Yu Xie, Zhi-Han Wang, Min Yang, Rui He, Yan Yang, Zhe-Long Liu, Jun-Hui Xie, De-Lin Ma, Ben-Ping Zhang, Shi-Ying Shao, Xi Chen, Si-Miao Xu, Wen-Tao He, Wen-Jun Li, Yong Chen, Xue-Feng Yu   +26 more
doaj   +1 more source

Image4_Analysis of the Expression and Prognostic Potential of a Novel Metabolic Regulator ANGPTL8/Betatrophin in Human Cancers.TIF

, 2021
The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584), Yuqing Chen (231681), Dandan Tian (11482879), Fangfang Xu (1830163), Xiaoyang Shi (4167553)   +4 more
core   +1 more source

Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D [PDF]

Lipids in Health and Disease, 2016
Hypertriglyceridemia is associated with increased risk for cardiovascular diseases and type 2 diabetes (T2D). Angiopoietin like proteins particularly 3, 4 and recently 8 are well established regulators of plasma triglyceride level through regulating the activity of lipoprotein lipase.
Mohamed Abu-Farha, Irina Al-Khairi, Preethi Cherian, Betty Chandy, Devarajan Sriraman, Asma Alhubail, Faisal Al-Refaei, Abdulmohsen AlTerki, Jehad Abubaker   +8 more
openaire   +2 more sources

Leukocyte immunoglobulin‐like receptor B2 regulates atherosclerosis progression by modulating macrophage extracellular trap formation in foam macrophages through the PI3K‐AKT signaling pathway

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Our research examined how leukocyte immunoglobulin‐like receptor B2 (LILRB2) impacts macrophage extracellular trap (MET) formation in foam macrophages within atherosclerosis (AS). Results highlighted LILRB2's key role in AS, suggesting it may influence PI3K/AKT signaling to spur MET formation.
Yuanyong Jiao, Rui Hu, Liang Gui, Suyu Miu, Xiwei Zhang, Junjie Zou   +5 more
wiley   +1 more source