Results 61 to 70 of about 1,162 (153)

Correction: ANGPTL8 is a negative regulator in pathological cardiac hypertrophy. [PDF]

Cell Death Dis
Hu L, Wei J, Zhang Y, Wang Z, Tang J, Tang J, Gao Y, Zhang X, Li Y, Liu Y, Ma S, Guo X, Zhang Q.   +12 more
europepmc   +3 more sources

A Conserved FABP5high Macrophage Subset Promotes Fibrosis and Carcinogenesis in Advanced Liver Disease

Liver International, Volume 45, Issue 9, September 2025.
ABSTRACT Background and Aims The relationship between chronic liver disease and liver cancer remains poorly understood, and treatment options for advanced liver disease remain limited. This study aims to elucidate the dynamic evolution of cellular and molecular alterations from normal liver to diseased liver.
Wenhao Ge, Lifeng Ma, Yu Huang, Weigao E, Shujing Lai, Bijun Cui, Jingjing Wang, Yutian Ji, Daiyuan Liu, Song Ye, Yang Kong, Jiarong Zhou, Chengxuan Yu, Yingsheng Wu, Qiang Sun, Dongkai Zhou, Wei Zhu, Yuan Ding, Xiaoping Han, Guoji Guo, Weilin Wang   +20 more
wiley   +1 more source

Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
ANGPTL8, expressed mainly in the liver and adipose tissue, regulates the activity of lipoprotein lipase (LPL) present in the extracellular space and triglyceride (TG) metabolism through its interaction with ANGPTL3 and ANGPTL4. Whether intracellular ANGPTL8 can also exert effects in tissues where it is expressed is uncertain. ANGPTL8 expression was low
Anindya, Ghosh, Yat Hei, Leung, Jeffrey, Yu, Robert, Sladek, Isabelle, Chénier, Abel K, Oppong, Marie-Line, Peyot, S R Murthy, Madiraju, Irina, Al-Khairi, Thangavel Alphonse, Thanaraj, Jehad, Abubaker, Fahd, Al-Mulla, Marc, Prentki, Mohamed, Abu-Farha   +13 more
openaire   +2 more sources

Circulating ANGPTL8 levels and risk of kidney function decline: Results from the 4C Study

Cardiovascular Diabetology, 2021
Background ANGPTL8, an important regulator of lipid metabolism, was recently proven to have additional intracellular and receptor-mediated functions. This study aimed to investigate circulating levels of ANGPTL8 and its potential association with the ...
Huajie Zou, Yongping Xu, Xiaoyu Meng, Danpei Li, Xi Chen, Tingting Du, Yan Yang, Yong Chen, Shiying Shao, Gang Yuan, Xinrong Zhou, Shuhong Hu, Wentao He, Delin Ma, Junhui Xie, Benping Zhang, Jianhua Zhang, Wenjun Li, Zhelong Liu, Xuefeng Yu   +19 more
doaj   +1 more source

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

Animal Models and Experimental Medicine, Volume 8, Issue 7, Page 1215-1228, July 2025.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang, Yiming Liu, Dan Chen, Leiming Liu, Leimin Sun, Lingling Zhang   +5 more
wiley   +1 more source

The predictive diagnosis for ANGPTL8 level in women with T2DM

International journal of health sciences, 2022
Background: The metabolic syndrome including type 2 diabetes mellitus(T2DM), insulin resistance(IR), obese, hypertension, and dyslipidemia,  is an increasing health burden. In the last decade, various metabolic hormones have been noticed to significantly role obese and associated complications.
Aws Safaa Fadhel, Manal F. AL-Khakani
openaire   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, Volume 12, Issue 18, May 15, 2025.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Mediators of Inflammation, 2019
Background. ANGPTL8 has been reported to be a regulator of lipid metabolism, and it is associated with insulin resistance (IR) and metabolic syndrome (MetS). We investigated whether ANGPTL8 plays a role in MetS. Methods.
Danlan Pu, Ling Li, Jingxia Yin, Rui Liu, Gangyi Yang, Yong Liao, Qinan Wu   +6 more
doaj   +1 more source

Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Immunity and cancer interplay are central to tumor progression. This review explores how tumor cells exploit extracellular vesicles (EVs) to orchestrate immune evasion. Tumor‐derived EVs (TEVs) transport immunomodulatory cargo to shape immune differentiation, activation, and function.
Xuanfan Liu, Kenneth K.W. To, Qinsong Zeng, Liwu Fu   +3 more
wiley   +1 more source

ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac progenitor cells

Oncotarget, 2016
Established adriamycin cardiomyopathy is a lethal disease. When congestive heart failure develops, mortality is approximately 50% in a year. It has been known that ANGPTLs has various functions in lipid metabolism, inflammation, cancer cell invasion, hematopoietic stem activity and diabetes.
Chen, Shuyuan, Chen, Jiaxi, Meng, Xing-Li, Shen, Jin-Song, Huang, Jing, Huang, Pintong, Pu, Zhaoxia, McNeill, Nathan H., Grayburn, Paul A.   +8 more
openaire   +3 more sources