Results 61 to 70 of about 1,199 (160)

Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids

Diabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5985-5995, October 2025.
Abstract Aims The aim of this study was to determine if retatrutide, a triple agonist of glucose‐dependent insulinotropic polypeptide (GIP) receptor, glucagon‐like peptide 1 (GLP‐1) receptor and glucagon (GCG) receptor, may lower serum triglyceride (TG) and low‐density lipoprotein cholesterol (LDL‐C) levels in part by decreasing circulating ...
Yi Wen, Deven Lemen, Yanzhu Lin, Yan Q. Chen, Ajit Regmi, William C. Roell, Melissa K. Thomas, Mark L. Hartman, Tamer Coskun, Zvonko Milicevic, Axel Haupt, Giacomo Ruotolo, Robert J. Konrad   +12 more
wiley   +1 more source

A Conserved FABP5high Macrophage Subset Promotes Fibrosis and Carcinogenesis in Advanced Liver Disease

Liver International, Volume 45, Issue 9, September 2025.
ABSTRACT Background and Aims The relationship between chronic liver disease and liver cancer remains poorly understood, and treatment options for advanced liver disease remain limited. This study aims to elucidate the dynamic evolution of cellular and molecular alterations from normal liver to diseased liver.
Wenhao Ge, Lifeng Ma, Yu Huang, Weigao E, Shujing Lai, Bijun Cui, Jingjing Wang, Yutian Ji, Daiyuan Liu, Song Ye, Yang Kong, Jiarong Zhou, Chengxuan Yu, Yingsheng Wu, Qiang Sun, Dongkai Zhou, Wei Zhu, Yuan Ding, Xiaoping Han, Guoji Guo, Weilin Wang   +20 more
wiley   +1 more source

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

Animal Models and Experimental Medicine, Volume 8, Issue 7, Page 1215-1228, July 2025.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang, Yiming Liu, Dan Chen, Leiming Liu, Leimin Sun, Lingling Zhang   +5 more
wiley   +1 more source

The Rise and the Fall of Betatrophin/ANGPTL8 as an Inducer ofβ-Cell Proliferation [PDF]

Journal of Diabetes Research, 2016
Diabetes is a global health problem that is caused by impaired insulin production from pancreaticβ-cells. Efforts to regenerateβ-cells have been advancing rapidly in the past two decades with progress made towards identifying new agents that induceβ-cells regeneration.
Mohamed Abu-Farha, Ashraf Al Madhoun, Jehad Abubaker   +2 more
openaire   +3 more sources

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Mediators of Inflammation, 2019
Background. ANGPTL8 has been reported to be a regulator of lipid metabolism, and it is associated with insulin resistance (IR) and metabolic syndrome (MetS). We investigated whether ANGPTL8 plays a role in MetS. Methods.
Danlan Pu, Ling Li, Jingxia Yin, Rui Liu, Gangyi Yang, Yong Liao, Qinan Wu   +6 more
doaj   +1 more source

Depletion of Hepatic SREBP2 Protects Against Hypercholesterolemia and Atherosclerosis through the ANGPTL3‐LPL Axis

Advanced Science, Volume 12, Issue 18, May 15, 2025.
This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang, Jia You Sarafina Choe, Yu Shi, Thi Tun Thi, Xiaoyun Cao, Yang Hu, Kai Yan Cheng, Hui Li, Yang Ji, Yan Liu, Matthew Ackers‐Johnson, Roger S.Y. Foo, Yujia Shen, Haojie Yu   +13 more
wiley   +1 more source

Angptl8 mediates food-driven resetting of hepatic circadian clock in mice [PDF]

Nature Communications, 2019
AbstractDiurnal light-dark cycle resets the master clock, while timed food intake is another potent synchronizer of peripheral clocks in mammals. As the largest metabolic organ, the liver sensitively responds to the food signals and secretes hepatokines, leading to the robust regulation of metabolic and clock processes.
Siyu Chen, Mengyang Feng, Shiyao Zhang, Zhewen Dong, Yifan Wang, Wenxiang Zhang, Chang Liu   +6 more
openaire   +3 more sources

Effect of Extracellular Vesicles Derived From Tumor Cells on Immune Evasion

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Immunity and cancer interplay are central to tumor progression. This review explores how tumor cells exploit extracellular vesicles (EVs) to orchestrate immune evasion. Tumor‐derived EVs (TEVs) transport immunomodulatory cargo to shape immune differentiation, activation, and function.
Xuanfan Liu, Kenneth K.W. To, Qinsong Zeng, Liwu Fu   +3 more
wiley   +1 more source

Association between ANGPTL3, 4, and 8 and lipid and glucose metabolism markers in patients with diabetes.

PLoS ONE, 2021
Lipid management, especially with respect to triglyceride (TG) metabolism, in patients with diabetes is not sufficient with current therapeutic agents, and new approaches for improvement are needed.
Marina Harada, Tadashi Yamakawa, Rie Kashiwagi, Akeo Ohira, Mai Sugiyama, Yasuyuki Sugiura, Yoshinobu Kondo, Yasuo Terauchi   +7 more
doaj   +1 more source

Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis

Obesity, Volume 33, Issue 3, Page 522-536, March 2025.
Abstract Objective Adipose tissue expands through hyperplasia and hypertrophy to store excess lipids, a process that is essential for the maintenance of metabolic homeostasis. The mechanisms regulating adipocyte recruitment from progenitors remain unclear.
Manal Al Dow, Blandine Secco, Mathilde Mouchiroud, Marianne Rochette, Gustavo R. Gilio, Mickael Massicard, Marilou Hardy, Yves Gélinas, William T. Festuccia, Mathieu C. Morissette, Venkata S. K. Manem, Mathieu Laplante   +11 more
wiley   +1 more source