Results 61 to 70 of about 1,534 (183)
Journal of Internal Medicine, Volume 300, Issue 3, Page 312-328, September 2026.Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Marcello Arca +16 more
wiley +1 more source
Frontiers in Endocrinology, 2018 Background: Hyperglycemia, insulin resistance and hypertriglyceridesmia are risk factors for albuminuria in type 2 diabetes. Angiopoietin-like Protein 8(ANGPTL8) is a newly identified liver-derived hormone related to these risk factors.
Liuxue Yang +10 more
doaj +1 more source
ANGPTL8 level obese vs. non-obese.
, 2016 A: Level of full length form of ANGPTL8 in non-obese vs. obese subjects in circulation. B: Level of C-terminal 139–198 form of ANGPTL8 in non-obese vs. obese subjects in circulation.
Mohamed Abu-Farha (25322) +6 more
core +1 more source
, 2021 The angiopoietin-like protein (ANGPTL) family members, except for the novel atypical member ANGPTL8/betatrophin, have been reported to participate in angiogenesis, inflammation and cancer.
Kai Sun (140584) +4 more
core +1 more source
LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis
Nature Communications, 2023 Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog receptor, leukocyte immunoglobulin-like receptor B (
Dan-Pei Li +26 more
doaj +1 more source
Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
Journal of Lipid Research, 2021 High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhibits
Kelli L. Sylvers-Davie +4 more
doaj +1 more source
Enriched Metabolic Phenotyping Refines Phenotypic Resolution of Type 2 Diabetes
Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6674-6686, August 2026.ABSTRACT Aims Data‐driven clustering studies of type 2 diabetes (T2D) based on limited routine clinical variables have reproducibly described major metabolic subgroups, including severe insulin‐deficient diabetes (SIDD), severe insulin‐resistant diabetes (SIRD), mild obesity‐related diabetes and mild age‐related diabetes.
Min Wang +6 more
wiley +1 more source
Lipids in Health and Disease, 2018 Background Angiopoietin-like protein 8 (ANGPTL8) is a novel hormone involved in the regulation of lipid metabolism and glucose homeostasis. There are inconsistent results regarding the association between ANGPTL8 and lipids in humans.
Song Yang +8 more
doaj +1 more source
Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training. [PDF]
PLoS ONE, 2016 OBJECTIVE:ANGPTL8 is a liver and adipose tissue produced protein that regulates the level of triglyceride in plasma as well as glucose homeostasis. This study was designed to evaluate the level of ANGPTL8 in obese and non-obese subjects before and after ...
Mohamed Abu-Farha +6 more
doaj +1 more source
Advanced Science, Volume 13, Issue 10, 18 February 2026.This study uncovers a recipient‐derived monocyte‐to‐macrophage trajectory that drives inflammation during kidney transplant rejection. Using over 150 000 single‐cell profiles and more than 850 biopsies, the authors identify CXCL10+ macrophages as key predictors of graft loss.
Alexis Varin +16 more
wiley +1 more source