Results 41 to 50 of about 1,162 (153)

MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2017
Abstract Context Angiopoietin-like 8 (ANGPTL8) has been identified as a key regulator of lipid metabolism. Design We addressed the correlation between ANGPTL8 messenger RNA (mRNA) with hallmark insulin-regulated and lipogenic genes in
Raghavendra, Mysore, Francisco J, Ortega, Jèssica, Latorre, Maria, Ahonen, Hanna, Savolainen-Peltonen, Pamela, Fischer-Posovszky, Martin, Wabitsch, Vesa M, Olkkonen, José M, Fernández-Real, P A Nidhina, Haridas   +9 more
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Impact of oxygen concentration changes on ANGPTL8 expression of human pulmonary artery endothelial cells [PDF]

Jichu yixue yu linchuang
Objective To explore the impact of change in oxygen concentration on the expression of angiopoietin-like protein 8 (ANGPTL8) by endothelial cells (HPAECs) of human pulmonary artery, and the role and mechanism of ANGPTL8 in pulmonary hypertension (PH ...
ZHANG Zongli, LI Tao, MA Jingwen, ZHANG Jiaxin, LI Xingchao, XI Shibing
doaj   +1 more source

Adolescent obesity and ANGPTL8: correlations with high sensitivity C-reactive protein, leptin, and chemerin

Frontiers in Endocrinology, 2023
Angiopoietin-like proteins (ANGPTLs) mediate many metabolic functions. We had recently reported increased plasma levels of ANGPTL8 in obese adults of Arab ethnicity. However, data on ANGPTL8 levels in adolescent obesity is lacking.
Maha M. Hammad, Arshad M. Channanath, Mohamed Abu-Farha, Abdur Rahman, Irina Al Khairi, Preethi Cherian, Tahani Alramah, Nada Alam-Eldin, Fahd Al-Mulla, Thangavel Alphonse Thanaraj, Jehad Abubaker   +10 more
doaj   +1 more source

ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance[S]

Journal of Lipid Research, 2017
Angiopoietin-like (ANGPTL)3 and ANGPTL8 are secreted proteins and inhibitors of LPL-mediated plasma triglyceride (TG) clearance. It is unclear how these two ANGPTL proteins interact to regulate LPL activity.
Jorge F. Haller, Ivory J. Mintah, Lisa M. Shihanian, Panayiotis Stevis, David Buckler, Corey A. Alexa-Braun, Sandra Kleiner, Serena Banfi, Jonathan C. Cohen, Helen H. Hobbs, George D. Yancopoulos, Andrew J. Murphy, Viktoria Gusarova, Jesper Gromada   +13 more
doaj   +1 more source

Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes

Journal of Diabetes Research, 2017
The objectives of the study were to investigate serum ANGPTL8 concentrations in different glucose metabolic statuses and to explore the correlations between serum ANGPTL8 levels and various metabolic parameters. Serum ANGPTL8 levels were determined using
Yanhua Yin, Xiaoying Ding, Liang Peng, Yanqiang Hou, Yunxia Ling, Mingyu Gu, Yufan Wang, Yongde Peng, Haiyan Sun   +8 more
doaj   +1 more source

Angiopoietin-Like 8 in Gestational Diabetes Mellitus: Reduced Levels in Third Trimester Maternal Serum and Placenta, Increased Levels in Cord Blood Serum

International Journal of Endocrinology, 2022
Gestational diabetes mellitus (GDM) poses a significant health risk to pregnant women, and thus exploring the potential underlying mechanism is highly desirable.
Junhua Yuan, Di Zhang, Yunyang Wang, Zhen Zhu, Qian Lin, Manwen Li, Weizhen Zhong, Jing Han, Fengsen Xu, Jing Dong   +9 more
doaj   +1 more source

Angiopoietin-like protein 8 promotes apoptosis of vascular smooth muscle cells through activating p53 signaling pathway [PDF]

Jichu yixue yu linchuang
Objective To investigate the mechanism by which angiopoietin-like protein 8 (ANGPTL8) regulates vascular smooth muscle cell (VSMCs) apoptosis. Methods An in vitro abdominal aortic aneurysm cell model was established by stimulating human VSMCs(HUSMCs ...
YU Huahui, DU Zhiyong, JIAO Xiaolu, LYU Qianwen, YANG Yunyun, HAN Lijie, QIN Yanwen
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ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Frontiers in Endocrinology, 2022
BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo   +14 more
doaj   +1 more source

Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China

Cardiovascular Diabetology, 2018
Background Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors.
Tianpeng Zheng, Bo Ge, Hongbo Liu, Bo Chen, Linyuan Qin, Liuping Xiao, Jianfei Song   +6 more
doaj   +1 more source

Circulating Angptl3 and Angptl8 Are Increased in Patients with Hypothyroidism

BioMed Research International, 2019
Purpose. Angiopoietin-like proteins (Angptls) play critical roles in biological processes, primarily in lipid metabolism. The functional state of the thyroid has a profound influence on metabolism in the human body. Therefore, the aim of this study was to investigate possible changes in serum Angptl3, 4, and 8 levels in hypothyroid patients.
Longyan Yang, Ruili Yin, Zongwei Wang, Xiaobo Wang, Yuanyuan Zhang, Dong Zhao   +5 more
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