Results 41 to 50 of about 1,534 (183)

Positive correlation of ANGPTL8 expression in human visceral adipose tissue with body mass index

Journal of the Formosan Medical Association
Background: Angiopoietin-like protein 8 (ANGPTL8) is an important regulator of lipid metabolism. We aimed to investigate the difference of ANGPTL8 expression in different depots of adipose tissues between individuals with and without obesity, and its ...
Shiau-Mei Chen, Tse-Ying Huang, Wei-Jei Lee, Lee-Ming Chuang, Tien-Jyun Chang   +4 more
doaj   +2 more sources

Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis [PDF]

Medicina
Background and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary infections, and organ failure ...
Perihan Ozkan Gumuskaya, Emine Yildirim, Ozgur Altun, Hafize Uzun   +3 more
doaj   +2 more sources

Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome [PDF]

Cell & Bioscience
Cytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting M2 macrophage ...
Yang Su, Rongtian Zhang, Kongdong Li, Hong Shen, Mengjiao Nan, Chang Liu, Wenxiang Zhang, Siyu Chen   +7 more
doaj   +2 more sources

Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension

Lipids in Health and Disease, 2018
Background Hypertension is a risk factor for both cardiovascular diseases (CVDs) and type 2 diabetes (T2D). Angiopoietin-like proteins (ANGPTLs), mainly ANGPTL3, ANGPTL4 and ANGPTL8, are associated with increased plasma lipid content due to their role in
Mohamed Abu-Farha, Preethi Cherian, Mohamed G. Qaddoumi, Irina AlKhairi, Devarajan Sriraman, Muath Alanbaei, Jehad Abubaker   +6 more
doaj   +2 more sources

Circulating ANGPTL8 Is Associated with the Presence of Metabolic Syndrome and Insulin Resistance in Polycystic Ovary Syndrome Young Women

Mediators of Inflammation, 2019
Background. ANGPTL8 has been reported to be a regulator of lipid metabolism, and it is associated with insulin resistance (IR) and metabolic syndrome (MetS). We investigated whether ANGPTL8 plays a role in MetS. Methods.
Danlan Pu, Ling Li, Jingxia Yin, Rui Liu, Gangyi Yang, Yong Liao, Qinan Wu   +6 more
doaj   +2 more sources

Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8 [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2021
Abstract Context ANGPTL8 (A8) plays a key role in determining the tissue fate of circulating triglycerides (TGs). Plasma A8 levels are associated with several parameters of glucose and TG metabolism, but the causality of these relationships and the contribution of genetic variants to differences in A8
Federico Oldoni, Kevin Bass, Julia Kozlitina, Hannah Hudson, Lisa M Shihanian, Viktoria Gusarova, Jonathan C Cohen, Helen H Hobbs   +7 more
openaire   +3 more sources

ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation

Journal of Lipid Research
Liver injury is closely related to poor outcomes in sepsis patients. Current studies indicate that sepsis is accompanied by metabolic disorders, especially those related to lipid metabolism.
Ying Feng, Shan Luo, Chen Fang, Shinan Ma, Dandan Fan, Yanghui Chen, Zhuo Chen, Xiang Zheng, Yijun Tang, Xiaobei Duan, Xingling Liu, Xuzhi Ruan, Xingrong Guo   +12 more
doaj   +2 more sources

Perspectives on the Activities of ANGPTL8/Betatrophin [PDF]

Cell, 2014
In this issue of Cell, Gusarova et al. (2014) show that deletion of ANGPTL8 in mice does not affect the compensatory proliferation of pancreatic beta cells in response to insulin resistance induced by a high-fat diet or treatment with the insulin antagonist S961. They also show that overexpression of human ANGPTL8 in mouse liver leads to elevated serum
Yi, Peng, Park, Ji-Sun, Melton, Douglas A.   +2 more
openaire   +2 more sources

Evidences for Expression and Location of ANGPTL8 in Human Adipose Tissue [PDF]

Journal of Clinical Medicine, 2020
The metabolism of triglycerides (TGs) is regulated, among others, by the lipoprotein lipase (LPL) that hydrolyses the TGs on endothelial cells. In turn, LPL is inhibited by the ANGPTLs family of proteins, such as ANGPTL3, 4, and, 8; the latter is the least known.
Leonardo Catalano-Iniesta, Virginia Sánchez Robledo, María Carmen Iglesias-Osma, Amparo Galán Albiñana, Sixto Carrero, Enrique J. Blanco, Marta Carretero-Hernández, José Carretero, María José García-Barrado   +8 more
openaire   +5 more sources

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition [PDF]

, 2017
Angiopoietin-like 8 (Angptl8) inhibits lipolysis in the circulation together with Angplt3 and controls post-prandial fat storage in white adipose tissue (WAT). It is strongly induced by insulin in vivo in WAT and in vitro in adipocytes.
Vesa M. Olkkonen, Mysore, Raghavendra, You Zhou, Haridas, P. A. Nidhina, Nidhina Haridas, P. A., Zhou, You, P.A. Nidhina Haridas, Nidhina Haridas, P.A., Gerhard Liebisch, Olkkonen, Vesa M., Liebisch, Gerhard, Raghavendra Mysore   +11 more
core   +1 more source