Results 41 to 50 of about 1,431 (182)

Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training. [PDF]

PLoS ONE, 2016
OBJECTIVE:ANGPTL8 is a liver and adipose tissue produced protein that regulates the level of triglyceride in plasma as well as glucose homeostasis. This study was designed to evaluate the level of ANGPTL8 in obese and non-obese subjects before and after ...
Mohamed Abu-Farha, Devarajan Sriraman, Preethi Cherian, Irina AlKhairi, Naser Elkum, Kazem Behbehani, Jehad Abubaker   +6 more
doaj   +4 more sources

Increased plasma and adipose tissue levels of ANGPTL8/Betatrophin and ANGPTL4 in people with hypertension

Lipids in Health and Disease, 2018
Background Hypertension is a risk factor for both cardiovascular diseases (CVDs) and type 2 diabetes (T2D). Angiopoietin-like proteins (ANGPTLs), mainly ANGPTL3, ANGPTL4 and ANGPTL8, are associated with increased plasma lipid content due to their role in
Mohamed Abu-Farha, Preethi Cherian, Mohamed G. Qaddoumi, Irina AlKhairi, Devarajan Sriraman, Muath Alanbaei, Jehad Abubaker   +6 more
doaj   +2 more sources

Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8 [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2021
Abstract Context ANGPTL8 (A8) plays a key role in determining the tissue fate of circulating triglycerides (TGs). Plasma A8 levels are associated with several parameters of glucose and TG metabolism, but the causality of these relationships and the contribution of genetic variants to differences in A8
Federico Oldoni, Kevin Bass, Julia Kozlitina, Hannah Hudson, Lisa M Shihanian, Viktoria Gusarova, Jonathan C Cohen, Helen H Hobbs   +7 more
openaire   +3 more sources

Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus–A Co-expression Network Based Analysis

Frontiers in Physiology, 2018
Angiopoietin like protein 8 (ANGPTL8) is a newly identified hormone with unique nature due to its ability to regulate both glucose and lipid metabolic pathways.
Amnah Siddiqa, Amnah Siddiqa, Elisa Cirillo, Samar H. K. Tareen, Amjad Ali, Martina Kutmon, Martina Kutmon, Lars M. T. Eijssen, Jamil Ahmad, Jamil Ahmad, Chris T. Evelo, Chris T. Evelo, Susan L. Coort   +12 more
doaj   +2 more sources

Evidences for Expression and Location of ANGPTL8 in Human Adipose Tissue [PDF]

Journal of Clinical Medicine, 2020
The metabolism of triglycerides (TGs) is regulated, among others, by the lipoprotein lipase (LPL) that hydrolyses the TGs on endothelial cells. In turn, LPL is inhibited by the ANGPTLs family of proteins, such as ANGPTL3, 4, and, 8; the latter is the least known.
Leonardo Catalano-Iniesta, Virginia Sánchez Robledo, María Carmen Iglesias-Osma, Amparo Galán Albiñana, Sixto Carrero, Enrique J. Blanco, Marta Carretero-Hernández, José Carretero, María José García-Barrado   +8 more
openaire   +6 more sources

Perspectives on the Activities of ANGPTL8/Betatrophin [PDF]

Cell, 2014
In this issue of Cell, Gusarova et al. (2014) show that deletion of ANGPTL8 in mice does not affect the compensatory proliferation of pancreatic beta cells in response to insulin resistance induced by a high-fat diet or treatment with the insulin antagonist S961. They also show that overexpression of human ANGPTL8 in mouse liver leads to elevated serum
Yi, Peng, Park, Ji-Sun, Melton, Douglas A.   +2 more
openaire   +2 more sources

ANGPTL8 has both endocrine and autocrine effects on substrate utilization [PDF]

JCI Insight, 2020
The angiopoietin-like protein ANGPTL8 (A8) is one of 3 ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is expressed in liver and adipose tissue, is required to redirect dietary TG from oxidative to storage ...
Federico Oldoni, Haili Cheng, Serena Banfi, Viktoria Gusarova, Jonathan C. Cohen, Helen H. Hobbs   +5 more
openaire   +3 more sources

Liver-specific knockdown of ANGPTL8 alters the structure of the gut microbiota in mice

Annals of Microbiology, 2020
Purpose To investigate the effect of liver-specific knockdown of ANGPTL8 on the structure of the gut microbiota. Methods We constructed mice with liver-specific ANGPTL8 knockdown by using an adeno-associated virus serotype 8 (AAV8) system harbouring an ...
Yinlong Cheng, Yining Li, Yonghong Xiong, Yixin Zou, Siyu Chen, Wenxiang Zhang, Chang Liu, Yujie Shi   +7 more
doaj   +1 more source

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition [PDF]

, 2017
Angiopoietin-like 8 (Angptl8) inhibits lipolysis in the circulation together with Angplt3 and controls post-prandial fat storage in white adipose tissue (WAT). It is strongly induced by insulin in vivo in WAT and in vitro in adipocytes.
Vesa M. Olkkonen, Mysore, Raghavendra, You Zhou, Haridas, P. A. Nidhina, Nidhina Haridas, P. A., Zhou, You, P.A. Nidhina Haridas, Nidhina Haridas, P.A., Gerhard Liebisch, Olkkonen, Vesa M., Liebisch, Gerhard, Raghavendra Mysore   +11 more
core   +1 more source

Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study [PDF]

Frontiers in Public Health, 2021
Background: Chronic kidney disease (CKD) is recognized as a major public health problem with high morbidity and mortality worldwide. Recently, angiopoietin-like protein 8 (ANGPTL8) was found to regulate lipid metabolism. Previous studies suggested that serum ANGPTL8 levels increased in patients with diabetes, especially in diabetic patients with ...
Xiaoyu Meng, Xiaoyu Meng, Huajie Zou, Huajie Zou, Danpei Li, Danpei Li, Peng Yu, Peng Yu, Li Huang, Li Huang, Jianhua Zhang, Jianhua Zhang, Wenjun Li, Xuefeng Yu, Xuefeng Yu   +14 more
openaire   +3 more sources