Results 41 to 50 of about 1,199 (160)
Frontiers in Endocrinology, 2022 BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang +14 more
doaj +1 more source
Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
Metabolites, 2022 Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains unclear.
Anna Stefanska +5 more
openaire +3 more sources
ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion [PDF]
Cell, 2014 Recently, it was reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic beta cell proliferation. However, studies of Angptl8(?/?) mice revealed profound reduction of triglyceride levels, but no abnormalities in glucose homeostasis.
Gusarova, Viktoria +10 more
openaire +2 more sources
Lipids in Health and Disease, 2018 Background Angiopoietin-like protein 8(ANGPTL8) and apolipoprotein CIII (apoCIII) were found to inhibit the activity of lipoprotein lipase (LPL) and disrupt the clearance of triglyceride-rich lipoproteins (TRLs), leading to hypertriglyceridemia.
Mengdie Luo +4 more
doaj +1 more source
Biomedicines, 2022 Sepsis is defined by life-threatening organ dysfunction mediated by the host’s response to infection. This can result in septic dyslipidemia, which is involved in the neutralization of pathogen-related lipids. Knowledge of the regulatory mechanisms of septic dyslipidemia is incomplete.
Paul Horn +11 more
openaire +4 more sources
Cardiovascular Diabetology, 2018 Background Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors.
Tianpeng Zheng +6 more
doaj +1 more source
Targeted Metabolomics Analysis of Individuals Carrying the ANGPTL8 R59W Variant
Metabolites, 2023 ANGPTL8 is recognized as a regulator of lipid metabolism through its role in inhibiting lipoprotein lipase activity. ANGPTL8 gene variants, particularly rs2278426 leading to the R59W variant in the protein, have been associated with lipid traits in various ethnicities. We aimed to use metabolomics to understand the impact of the ANGPTL8 R59W variant on
Mohamed Abu-Farha +9 more
openaire +3 more sources
Frontiers in Endocrinology, 2018 Background: Hyperglycemia, insulin resistance and hypertriglyceridesmia are risk factors for albuminuria in type 2 diabetes. Angiopoietin-like Protein 8(ANGPTL8) is a newly identified liver-derived hormone related to these risk factors.
Liuxue Yang +10 more
doaj +1 more source
LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis
Nature Communications, 2023 Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog receptor, leukocyte immunoglobulin-like receptor B (
Dan-Pei Li +26 more
doaj +1 more source
Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8
Journal of Lipid Research, 2021 High plasma triglyceride (TG) levels and low HDL-C levels are risk factors for atherosclerosis and cardiovascular disease. Both plasma TG and HDL-C levels are regulated in part by the circulating inhibitor, angiopoietin-like 3 (ANGPTL3). ANGPTL3 inhibits
Kelli L. Sylvers-Davie +4 more
doaj +1 more source