Results 21 to 30 of about 1,162 (153)
Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids. [PDF]
Diabetes Obes MetabAbstract Aims The aim of this study was to determine if retatrutide, a triple agonist of glucose‐dependent insulinotropic polypeptide (GIP) receptor, glucagon‐like peptide 1 (GLP‐1) receptor and glucagon (GCG) receptor, may lower serum triglyceride (TG) and low‐density lipoprotein cholesterol (LDL‐C) levels in part by decreasing circulating ...
Wen Y +12 more
europepmc +2 more sources
Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training. [PDF]
PLoS ONE, 2016 OBJECTIVE:ANGPTL8 is a liver and adipose tissue produced protein that regulates the level of triglyceride in plasma as well as glucose homeostasis. This study was designed to evaluate the level of ANGPTL8 in obese and non-obese subjects before and after ...
Mohamed Abu-Farha +6 more
doaj +4 more sources
Biomedicines, 2022 Sepsis is defined by life-threatening organ dysfunction mediated by the host’s response to infection. This can result in septic dyslipidemia, which is involved in the neutralization of pathogen-related lipids.
Paul Horn +11 more
doaj +4 more sources
Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus–A Co-expression Network Based Analysis
Frontiers in Physiology, 2018 Angiopoietin like protein 8 (ANGPTL8) is a newly identified hormone with unique nature due to its ability to regulate both glucose and lipid metabolic pathways.
Amnah Siddiqa +12 more
doaj +4 more sources
ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation [PDF]
Journal of Lipid ResearchLiver injury is closely related to poor outcomes in sepsis patients. Current studies indicate that sepsis is accompanied by metabolic disorders, especially those related to lipid metabolism.
Ying Feng +12 more
doaj +2 more sources
Genetic and Metabolic Determinants of Plasma Levels of ANGPTL8 [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2021 Abstract Context ANGPTL8 (A8) plays a key role in determining the tissue fate of circulating triglycerides (TGs). Plasma A8 levels are associated with several parameters of glucose and TG metabolism, but the causality of these relationships and the contribution of genetic variants to differences in A8
Federico Oldoni +7 more
openaire +3 more sources
ANGPTL8 has both endocrine and autocrine effects on substrate utilization [PDF]
JCI Insight, 2020 The angiopoietin-like protein ANGPTL8 (A8) is one of 3 ANGPTLs (A8, A3, A4) that coordinate changes in triglyceride (TG) delivery to tissues by inhibiting lipoprotein lipase (LPL), an enzyme that hydrolyzes TG. Previously we showed that A8, which is expressed in liver and adipose tissue, is required to redirect dietary TG from oxidative to storage ...
Federico Oldoni +5 more
openaire +3 more sources
Oncogenesis, 2023 The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinogenesis, but their contributions to HCC development are incompletely understood.
Yujiu Gao +16 more
doaj +1 more source
Angiopoietin-like protein 8 promotes phenotypic transformation of rat aorta vascular smooth muscle cells [PDF]
Jichu yixue yu linchuang, 2022 Objective To explore the role and mechanism of angiopoietin-like protein 8 (ANGPTL8) on phenotypic transformation of rat aorta vascular smooth muscle cells (VSMCs).
SUN Qiu-ju, JIAO Xiao-lu, YU Hua-hui, LI Fan, LYU Qian-wen, WANG Yu, QIN Yan-wen
doaj +1 more source
ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE−/− mice
Clinical Science, 2023 Abstract Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose metabolism, inflammation, and cell proliferation and migration. Clinical studies have indicated that circulating ANGPTL8 levels are increased in patients with thoracic aortic dissection (TAD).
Huahui Yu +14 more
openaire +2 more sources