Results 21 to 30 of about 1,199 (160)

Neuropeptide Y-Positive Neurons in the Dorsomedial Hypothalamus Are Involved in the Anorexic Effect of Angptl8

Frontiers in Molecular Neuroscience, 2018
Angiopoietin-like protein 8 (Angptl8), a recently identified member of the angiopoietin-like protein family (ANGPTLs), is a 22-kDa peptide synthesized in the liver.
Yuan Liu, Junhua Yuan
exaly   +3 more sources

Liver-specific expression of ANGPTL8 promotes Alzheimer’s disease progression through activating microglial pyroptosis [PDF]

Journal of Neuroinflammation
Introduction Liver dysfunction contributes to Alzheimer’s disease (AD) pathogenesis, and evidence suggests that the liver is involved in amyloid β (Aβ) clearance, and regulates Aβ deposition in the brain.
Jiarui Wei, Lin Hu, Shufan Xu, Fan Yang, Fusheng Liao, Ying Tang, Xin Shen, Xiaoqiao Zhang, Xinggang Fang, Yifan Li, Li Ding, Zhuo Chen, Shanchun Su, Junhua Cheng, Yong Huang, Qian Chen, Daqing Ma, Qiufang Zhang, Xingrong Guo   +18 more
doaj   +2 more sources

ANGPTL8 accelerates bone loss in diabetic mice by promoting osteoclastic differentiation and inhibiting osteoblastic differentiation through AMPK pathway-mediated metabolic reprogramming [PDF]

Cellular and Molecular Life Sciences
Disruptions in energy metabolism within skeletal cells play a critical role in the pathogenesis of diabetic osteoporosis (DOP), primarily by affecting bone’s metabolic balance.
Peng Tuo, Wenbo Mu, Xinyu Bai, Suyin Wang, Liang Hu, Yining Xu, Ruopu Mao, Yixiang Liu, Yahong Yuan, Qiufang Zhang, Xingrong Guo, Shinan Ma, Xiaoli Wang   +12 more
doaj   +2 more sources

The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation

Cells, 2023
Background: Angiopoietin-like protein 8 (ANGPTL8) is known to regulate lipid metabolism and inflammation. It interacts with ANGPTL3 and ANGPTL4 to regulate lipoprotein lipase (LPL) activity and with IKK to modulate NF-κB activity.
Fahd Al-Mulla, Rasheed Ahmad, Anwar Mohammad   +2 more
exaly   +3 more sources

Associations Between APOC3 and ANGPTL8 Gene Polymorphisms With MASLD Risk and the Mediation Effect of Triglyceride on MASLD in the Chinese Population. [PDF]

J Cell Mol Med
ABSTRACT Apolipoprotein C3 (APOC3) and angiopoietin‐like protein 8 (ANGPTL8) genes are related to lipid metabolism. The relationships between single nucleotide polymorphisms (SNPs) in the APOC3 and ANGPTL8 genes with metabolic dysfunction‐associated steatotic liver disease (MASLD) remain controversial.
Pan J, Wang X, Zhang Y, Wang T, Lv S, Zhang X, Zhou Y, Peng T, Song Y.   +8 more
europepmc   +2 more sources

ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase

Molecular Metabolism, 2017
Objective: Several members of the angiopoietin-like (ANGPTL) family of proteins, including ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity.
Xun Chi, Emily C. Britt, Hannah W. Shows, Alexander J. Hjelmaas, Shwetha K. Shetty, Emily M. Cushing, Wendy Li, Alex Dou, Ren Zhang, Brandon S.J. Davies   +9 more
doaj   +3 more sources

Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway [PDF]

Journal of Neuroinflammation
Background Type 2 diabetes mellitus (T2D) is associated with an increased risk of cognitive dysfunction. Angiopoietin-like protein 8 (ANGPTL8) is an important regulator in T2D, but the role of ANGPTL8 in diabetes-associated cognitive dysfunction remains ...
Xiaoyu Meng, Danpei Li, Ranran Kan, Yuxi Xiang, Limeng Pan, Yaming Guo, Peng Yu, Peiqiong Luo, Huajie Zou, Li Huang, Yurong Zhu, Beibei Mao, Yi He, Lei Xie, Jialu Xu, Xiaoyan Liu, Wenjun Li, Yong Chen, Suiqiang Zhu, Yan Yang, Xuefeng Yu   +20 more
doaj   +2 more sources

Elevated ANGPTL8 (Angiopoietin‐Like Protein 8) Levels as a Novel Predictor of Atherosclerosis in Type 2 Diabetes: Beyond Lipid Metabolism [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background ANGPTL8 (angiopoietin‐like protein 8) regulates lipid metabolism, but its role in atherosclerosis among patients with type 2 diabetes, particularly through lipid‐independent mechanisms, remains unclear.
Huimin Ye, Qiang Zhu, Qunchuan Zong, Shanyu Luo, Zonghong Ji, Ruixia Zhang, Huajie Zou   +6 more
doaj   +2 more sources

Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis [PDF]

Medicina
Background and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary infections, and organ failure ...
Perihan Ozkan Gumuskaya, Emine Yildirim, Ozgur Altun, Hafize Uzun   +3 more
doaj   +2 more sources

The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity [PDF]

Cardiovascular Diabetology, 2018
Background It is well known that angiopoietin-like protein 8 (ANGPTL8) exerts its effects on lipid metabolism through the inhibition of lipoprotein lipase and subsequent elevation of plasma triglyceride.
Mengdie Luo, Ziyu Zhang, Yani Peng, Shuai Wang, Daoquan Peng   +4 more
doaj   +3 more sources