Results 21 to 30 of about 1,534 (183)

Impact of oxygen concentration changes on ANGPTL8 expression of human pulmonary artery endothelial cells [PDF]

Jichu yixue yu linchuang
Objective To explore the impact of change in oxygen concentration on the expression of angiopoietin-like protein 8 (ANGPTL8) by endothelial cells (HPAECs) of human pulmonary artery, and the role and mechanism of ANGPTL8 in pulmonary hypertension (PH ...
ZHANG Zongli, LI Tao, MA Jingwen, ZHANG Jiaxin, LI Xingchao, XI Shibing
doaj   +2 more sources

ANGPTL8 promotes adipogenic differentiation of mesenchymal stem cells: potential role in ectopic lipid deposition

Frontiers in Endocrinology, 2022
BackgroundEctopic lipid deposition plays a promoting role in many chronic metabolic diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an important cause of lipid deposition in organs.
Jian Tang, Jian Tang, Shinan Ma, Yujiu Gao, Fan Zeng, Ying Feng, Chong Guo, Lin Hu, Lingling Yang, Lingling Yang, Yanghui Chen, Qiufang Zhang, Yahong Yuan, Xingrong Guo, Xingrong Guo   +14 more
doaj   +2 more sources

Adipokine in Metabolic Liver Disease: Adipo-Brain-Liver Cross talk. [PDF]

Int J Endocrinol
Purpose Adipokines play a key role in the interaction between the brain, liver, and adipose tissue. In this review, we selected adipokines with wide central receptor expression and summarized their indirect regulation on liver metabolism by acting on specific neurons and inducing neuropeptide production.
Su Y, Yang Y, Sun W, Yu Z, Wang Y, Liu S, Chen Z, Li Y, Yang X, Liu J, Han C, Wang Y, Yuan J.   +12 more
europepmc   +2 more sources

The predictive diagnosis for ANGPTL8 level in women with T2DM [PDF]

International journal of health sciences, 2022
Background: The metabolic syndrome including type 2 diabetes mellitus(T2DM), insulin resistance(IR), obese, hypertension, and dyslipidemia,  is an increasing health burden. In the last decade, various metabolic hormones have been noticed to significantly role obese and associated complications.
Aws Safaa Fadhel, Manal F. AL-Khakani
openaire   +2 more sources

ANGPTL8 is upregulated in subcutaneous adipose tissue at early term after bariatric surgery in patients living with obesity. [PDF]

Eur J Clin Invest
Bariatric surgery induces early immunological and transcriptomic modulations in subcutaneous adipose tissue, suggesting a transient pro‐inflammatory state and tissue remodeling process in patients living with obesity. ANGPTL8 could play a role in improving metabolic homeostasis at early‐term after bariatric surgery offering new insights into adipose ...
Negro EM, Fernández-García P, Martin-Taboada M, Soria-Gondek A, Marín DR, Pérez PC, Cortijo SM, Antolinez MÁ, Mora I, Martínez L, Ros M, Villarroya F, Cereijo R, Sánchez-Infantes D, Corrales P.   +14 more
europepmc   +2 more sources

ANGPTL8 regulates glucose metabolism in gestational diabetes mellitus mice, and proteomic analysis reveals the PI3K/Akt pathway plays its role in insulin-resistance HepG2 cells [PDF]

BMC Pregnancy and Childbirth
Background Insulin resistance (IR) is a pivotal determinant in the pathophysiological processes underlying gestational diabetes mellitus (GDM). Angiopoietin-like protein 8 (ANGPTL8) exhibits an ambiguous influence on glucose metabolism in the onset and ...
Xinping Xie, Jianying Yan, Xiaoyun Chen, Lidan He, Jianbo Wu, Lin Lu   +5 more
doaj   +2 more sources

Association between serum ANGPLT8 levels and atherogenic index of plasma in Chinese patients with type 2 diabetes mellitus [PDF]

Frontiers in Cardiovascular Medicine
AimsAngiopoietin-like protein 8 (ANGPTL8), a secreted adipokine, has been reported to be associated with lipid and glucose metabolism. This study aimed to evaluate the association between circulating levels of ANGPTL8 and atherogenic risk, assessed by ...
Xiaoya Sun
doaj   +2 more sources

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2⁺PIRB⁺ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis. [PDF]

Adv Sci (Weinh)
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Wei S, Shou D, Huang S, Wang Y, Liu Q, Liu J, Lv X, Zeng Y, Wei L, Lin H, Chen J, Chen Y, Zhong H, Zhou Y, Ma W, Wang L, Qian G, Guo J, Sun D.   +18 more
europepmc   +2 more sources

ANGPTL8 links refeeding to monocyte dynamics and metabolic inflammation via the CCL5-CCR5 axis [PDF]

JCI Insight
Metabolic inflammation is closely linked to dynamic changes in circulating monocyte populations, yet how nutritional signals regulate this process remains unclear.
Ran-Ran Kan, Si-Yi Wang, Xiao-Yu Meng, Li Huang, Yu-Xi Xiang, Bei-Bei Mao, Hua-Jie Zou, Ya-Ming Guo, Li-Meng Pan, Pei-Qiong Luo, Yan Yang, Zhe-Long Liu, De-Lin Ma, Wen-Jun Li, Yong Chen, Dan-Pei Li, Xue-Feng Yu   +16 more
doaj   +2 more sources

Targeted Metabolomics Analysis of Individuals Carrying the ANGPTL8 R59W Variant

Metabolites, 2023
ANGPTL8 is recognized as a regulator of lipid metabolism through its role in inhibiting lipoprotein lipase activity. ANGPTL8 gene variants, particularly rs2278426 leading to the R59W variant in the protein, have been associated with lipid traits in various ethnicities. We aimed to use metabolomics to understand the impact of the ANGPTL8 R59W variant on
Mohamed Abu-Farha, Shibu Joseph, Anwar Mohammad, Arshad Channanath, Ibrahim Taher, Fahd Al-Mulla, Muhammad Mujammami, Thangavel Alphonse Thanaraj, Jehad Abubaker, Anas M. Abdel Rahman   +9 more
openaire   +4 more sources