Results 21 to 30 of about 1,431 (182)

Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis

Oncogenesis, 2023
The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinogenesis, but their contributions to HCC development are incompletely understood.
Yujiu Gao, Yue Yuan, Shu Wen, Yanghui Chen, Zongli Zhang, Ying Feng, Bin Jiang, Shinan Ma, Rong Hu, Chen Fang, Xuzhi Ruan, Yahong Yuan, Xinggang Fang, Chao Luo, Zhongji Meng, Xiaoli Wang, Xingrong Guo   +16 more
doaj   +2 more sources

Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells [PDF]

Frontiers in Endocrinology, 2021
This study aims to investigate the effect of angiopoietin like 8 (ANGPTL8) on gestational diabetes mellitus (GDM) and insulin resistance (IR). The GDM model was induced by high fat diet in mice, and IR was observed.
Yu Bai, Qiang Du, Le Zhang, Ling Li, Nana Wang, Bo Wu, Ping Li, Ling Li   +7 more
doaj   +3 more sources

ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion [PDF]

Cell, 2014
SummaryRecently, it was reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought “betatrophin” that could control pancreatic beta cell proliferation.
Gromada, Jesper, Gusarova, Viktoria, Hobbs, Helen H., Murphy, Andrew J., Yancopoulos, George D., Xin, Yurong, Na, Erqian, Bonner-Weir, Susan, Cohen, Jonathan C., Alexa, Corey A., Stevis, Panayiotis E.   +10 more
core   +3 more sources

Circulating ANGPTL8 as a Potential Protector of Metabolic Complications in Patients with Psoriasis

Journal of Clinical Medicine, 2023
Angiopoietin-like protein 8 (ANGPTL8) exerts pleiotropic effects, taking part in lipid and carbohydrate metabolism, inflammation, hematopoiesis and oncogenesis. So far, the exact molecular targets of ANGPTL8 remain poorly defined.
Tomasz W. Kaminski, Julia Nowowiejska, Magdalena Maciaszek, Anna Baran, Julita Anna Krahel, Iwona Flisiak   +5 more
core   +3 more sources

ANGPTL8 is upregulated in subcutaneous adipose tissue at early term after bariatric surgery in patients living with obesity. [PDF]

Eur J Clin Invest
Bariatric surgery induces early immunological and transcriptomic modulations in subcutaneous adipose tissue, suggesting a transient pro‐inflammatory state and tissue remodeling process in patients living with obesity. ANGPTL8 could play a role in improving metabolic homeostasis at early‐term after bariatric surgery offering new insights into adipose ...
Negro EM, Fernández-García P, Martin-Taboada M, Soria-Gondek A, Marín DR, Pérez PC, Cortijo SM, Antolinez MÁ, Mora I, Martínez L, Ros M, Villarroya F, Cereijo R, Sánchez-Infantes D, Corrales P.   +14 more
europepmc   +2 more sources

ANGPTL8 regulates glucose metabolism in gestational diabetes mellitus mice, and proteomic analysis reveals the PI3K/Akt pathway plays its role in insulin-resistance HepG2 cells [PDF]

BMC Pregnancy and Childbirth
Background Insulin resistance (IR) is a pivotal determinant in the pathophysiological processes underlying gestational diabetes mellitus (GDM). Angiopoietin-like protein 8 (ANGPTL8) exhibits an ambiguous influence on glucose metabolism in the onset and ...
Xinping Xie, Jianying Yan, Xiaoyun Chen, Lidan He, Jianbo Wu, Lin Lu   +5 more
doaj   +2 more sources

Association between serum ANGPLT8 levels and atherogenic index of plasma in Chinese patients with type 2 diabetes mellitus [PDF]

Frontiers in Cardiovascular Medicine
AimsAngiopoietin-like protein 8 (ANGPTL8), a secreted adipokine, has been reported to be associated with lipid and glucose metabolism. This study aimed to evaluate the association between circulating levels of ANGPTL8 and atherogenic risk, assessed by ...
Xiaoya Sun
doaj   +2 more sources

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2⁺PIRB⁺ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis. [PDF]

Adv Sci (Weinh)
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Wei S, Shou D, Huang S, Wang Y, Liu Q, Liu J, Lv X, Zeng Y, Wei L, Lin H, Chen J, Chen Y, Zhong H, Zhou Y, Ma W, Wang L, Qian G, Guo J, Sun D.   +18 more
europepmc   +2 more sources

Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes [PDF]

Journal of Diabetes Research, 2017
The objectives of the study were to investigate serum ANGPTL8 concentrations in different glucose metabolic statuses and to explore the correlations between serum ANGPTL8 levels and various metabolic parameters. Serum ANGPTL8 levels were determined using
Yanhua Yin, Xiaoying Ding, Liang Peng, Yanqiang Hou, Yunxia Ling, Mingyu Gu, Yufan Wang, Yongde Peng, Haiyan Sun   +8 more
doaj   +2 more sources

Targeted Metabolomics Analysis of Individuals Carrying the ANGPTL8 R59W Variant

Metabolites, 2023
ANGPTL8 is recognized as a regulator of lipid metabolism through its role in inhibiting lipoprotein lipase activity. ANGPTL8 gene variants, particularly rs2278426 leading to the R59W variant in the protein, have been associated with lipid traits in ...
Jehad Abubaker, Muhammad Mujammami, Shibu Joseph, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Arshad Channanath, Anwar Mohammad, Ibrahim Taher, Mohamed Abu-Farha, Anas M. Abdel Rahman   +9 more
core   +4 more sources