Results 11 to 20 of about 1,162 (153)

ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase

Molecular Metabolism, 2017
Objective: Several members of the angiopoietin-like (ANGPTL) family of proteins, including ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity.
Xun Chi, Shwetha K Shetty, Emily M Cushing   +2 more
exaly   +5 more sources

Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells [PDF]

Frontiers in Endocrinology, 2021
This study aims to investigate the effect of angiopoietin like 8 (ANGPTL8) on gestational diabetes mellitus (GDM) and insulin resistance (IR). The GDM model was induced by high fat diet in mice, and IR was observed.
Yu Bai, Qiang Du, Le Zhang, Ling Li, Nana Wang, Bo Wu, Ping Li, Ling Li   +7 more
doaj   +3 more sources

ANGPTL8 is a negative regulator in pathological cardiac hypertrophy

Cell Death and Disease, 2022
Pathological cardiac hypertrophy is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown.
Lin Hu, Jiarui Wei, Yue Zhang, Ziyuan Wang, Junming Tang, Jian Tang, Yujiu Gao, Xiaoqiao Zhang, Yifan Li, Yantong Liu, Shinan Ma, Xingrong Guo, Qiufang Zhang   +12 more
doaj   +3 more sources

Liver-specific expression of ANGPTL8 promotes Alzheimer’s disease progression through activating microglial pyroptosis [PDF]

Journal of Neuroinflammation
Introduction Liver dysfunction contributes to Alzheimer’s disease (AD) pathogenesis, and evidence suggests that the liver is involved in amyloid β (Aβ) clearance, and regulates Aβ deposition in the brain.
Jiarui Wei, Lin Hu, Shufan Xu, Fan Yang, Fusheng Liao, Ying Tang, Xin Shen, Xiaoqiao Zhang, Xinggang Fang, Yifan Li, Li Ding, Zhuo Chen, Shanchun Su, Junhua Cheng, Yong Huang, Qian Chen, Daqing Ma, Qiufang Zhang, Xingrong Guo   +18 more
doaj   +2 more sources

Emerging insights into the roles of ANGPTL8 beyond glucose and lipid metabolism

Frontiers in Physiology, 2023
Angiopoietin-like protein 8 (ANGPTL8) is a secreted protein predominantly expressed in liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by suppressing the activity of lipoprotein lipase (LPL) within the plasma.
Huimin Ye, Qunchuan Zong, Huajie Zou, Ruixia Zhang   +3 more
doaj   +3 more sources

The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity [PDF]

Cardiovascular Diabetology, 2018
Background It is well known that angiopoietin-like protein 8 (ANGPTL8) exerts its effects on lipid metabolism through the inhibition of lipoprotein lipase and subsequent elevation of plasma triglyceride.
Mengdie Luo, Ziyu Zhang, Yani Peng, Shuai Wang, Daoquan Peng   +4 more
doaj   +3 more sources

Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway [PDF]

Journal of Neuroinflammation
Background Type 2 diabetes mellitus (T2D) is associated with an increased risk of cognitive dysfunction. Angiopoietin-like protein 8 (ANGPTL8) is an important regulator in T2D, but the role of ANGPTL8 in diabetes-associated cognitive dysfunction remains ...
Xiaoyu Meng, Danpei Li, Ranran Kan, Yuxi Xiang, Limeng Pan, Yaming Guo, Peng Yu, Peiqiong Luo, Huajie Zou, Li Huang, Yurong Zhu, Beibei Mao, Yi He, Lei Xie, Jialu Xu, Xiaoyan Liu, Wenjun Li, Yong Chen, Suiqiang Zhu, Yan Yang, Xuefeng Yu   +20 more
doaj   +2 more sources

Elevated ANGPTL8 (Angiopoietin‐Like Protein 8) Levels as a Novel Predictor of Atherosclerosis in Type 2 Diabetes: Beyond Lipid Metabolism [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background ANGPTL8 (angiopoietin‐like protein 8) regulates lipid metabolism, but its role in atherosclerosis among patients with type 2 diabetes, particularly through lipid‐independent mechanisms, remains unclear.
Huimin Ye, Qiang Zhu, Qunchuan Zong, Shanyu Luo, Zonghong Ji, Ruixia Zhang, Huajie Zou   +6 more
doaj   +2 more sources

Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis [PDF]

Medicina
Background and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary infections, and organ failure ...
Perihan Ozkan Gumuskaya, Emine Yildirim, Ozgur Altun, Hafize Uzun   +3 more
doaj   +2 more sources

Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome [PDF]

Cell & Bioscience
Cytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting M2 macrophage ...
Yang Su, Rongtian Zhang, Kongdong Li, Hong Shen, Mengjiao Nan, Chang Liu, Wenxiang Zhang, Siyu Chen   +7 more
doaj   +2 more sources