Results 11 to 20 of about 1,534 (183)
Journal of Advanced Research, 2023 Introduction: High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD) by promoting chronic inflammation. However, the mechanisms are poorly understood.
Guo Xingrong, Jian Tang, Longjun Dai
exaly +4 more sources
An ANGPTL8-AKT2-mTOR Axis Drives Adipose Senescence and Aging-Related Functional Decline. [PDF]
Aging CellANGPTL8 increases with age in humans and mice and serves as a key predictor of biological aging and mortality. Adipocyte‐derived ANGPTL8 promotes cellular senescence through AKT2–mTOR signaling, whereas genetic deletion of Angptl8 attenuates adipose tissue aging and extends lifespan.
He Y +11 more
europepmc +3 more sources
ANGPTL8: An Important Regulator in Metabolic Disorders
Frontiers in Endocrinology, 2018 Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved.
Mengdie Luo, Daoquan Peng
doaj +4 more sources
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase
Molecular Metabolism, 2017 Objective: Several members of the angiopoietin-like (ANGPTL) family of proteins, including ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity.
Xun Chi +9 more
doaj +4 more sources
Emerging insights into the roles of ANGPTL8 beyond glucose and lipid metabolism
Frontiers in Physiology, 2023 Angiopoietin-like protein 8 (ANGPTL8) is a secreted protein predominantly expressed in liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by suppressing the activity of lipoprotein lipase (LPL) within the plasma.
Huajie Zou
exaly +5 more sources
The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity [PDF]
Cardiovascular Diabetology, 2018 Background It is well known that angiopoietin-like protein 8 (ANGPTL8) exerts its effects on lipid metabolism through the inhibition of lipoprotein lipase and subsequent elevation of plasma triglyceride.
Mengdie Luo +4 more
doaj +4 more sources
Oncogenesis, 2023 The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinogenesis, but their contributions to HCC development are incompletely understood.
Yujiu Gao +16 more
doaj +2 more sources
ANGPTL8 in metabolic homeostasis: more friend than foe?
Open Biology, 2021 ANGPTL8 is an important cytokine, which is significantly increased in type 2 diabetes mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown that ANGPTL8 can be used as a bio-marker of these metabolic disorders related diseases, and the
Guoyue Yuan, Guoyue Yuan, Xia Deng
exaly +3 more sources
Circulating ANGPTL8 as a Potential Protector of Metabolic Complications in Patients with Psoriasis
Journal of Clinical Medicine, 2023 Angiopoietin-like protein 8 (ANGPTL8) exerts pleiotropic effects, taking part in lipid and carbohydrate metabolism, inflammation, hematopoiesis and oncogenesis. So far, the exact molecular targets of ANGPTL8 remain poorly defined. We aimed to evaluate the serum concentration of ANGPTL8 in individuals with psoriasis and examine how systemic therapy ...
Anna Baran +5 more
openaire +3 more sources
ANGPTL8/Betatrophin Does Not Control Pancreatic Beta Cell Expansion [PDF]
Cell, 2014 Recently, it was reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought "betatrophin" that could control pancreatic beta cell proliferation. However, studies of Angptl8(?/?) mice revealed profound reduction of triglyceride levels, but no abnormalities in glucose homeostasis.
Gusarova, Viktoria +10 more
openaire +4 more sources