Results 11 to 20 of about 1,199 (160)

ANGPTL8: An Important Regulator in Metabolic Disorders

Frontiers in Endocrinology, 2018
Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved.
Daoquan Peng, Peng Daoquan
exaly   +5 more sources

Emerging insights into the roles of ANGPTL8 beyond glucose and lipid metabolism

Frontiers in Physiology, 2023
Angiopoietin-like protein 8 (ANGPTL8) is a secreted protein predominantly expressed in liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by suppressing the activity of lipoprotein lipase (LPL) within the plasma.
Huajie Zou
exaly   +5 more sources

ANGPTL8 is a negative regulator in pathological cardiac hypertrophy

Cell Death and Disease, 2022
Pathological cardiac hypertrophy is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown.
Lin Hu, Jiarui Wei, Yue Zhang, Ziyuan Wang, Junming Tang, Jian Tang, Yujiu Gao, Xiaoqiao Zhang, Yifan Li, Yantong Liu, Shinan Ma, Xingrong Guo, Qiufang Zhang   +12 more
doaj   +3 more sources

ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways

Journal of Advanced Research, 2023
Introduction: High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD) by promoting chronic inflammation. However, the mechanisms are poorly understood.
Guo Xingrong, Jian Tang, Longjun Dai
exaly   +3 more sources

ANGPTL8 in metabolic homeostasis: more friend than foe?

Open Biology, 2021
ANGPTL8 is an important cytokine, which is significantly increased in type 2 diabetes mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown that ANGPTL8 can be used as a bio-marker of these metabolic disorders related diseases, and the
Guoyue Yuan, Guoyue Yuan, Xia Deng
exaly   +3 more sources

Silencing of ANGPTL8 Alleviates Insulin Resistance in Trophoblast Cells [PDF]

Frontiers in Endocrinology, 2021
This study aims to investigate the effect of angiopoietin like 8 (ANGPTL8) on gestational diabetes mellitus (GDM) and insulin resistance (IR). The GDM model was induced by high fat diet in mice, and IR was observed.
Yu Bai, Qiang Du, Le Zhang, Ling Li, Nana Wang, Bo Wu, Ping Li, Ling Li   +7 more
doaj   +3 more sources

ANGPTL8 is upregulated in subcutaneous adipose tissue at early term after bariatric surgery in patients living with obesity. [PDF]

Eur J Clin Invest
Bariatric surgery induces early immunological and transcriptomic modulations in subcutaneous adipose tissue, suggesting a transient pro‐inflammatory state and tissue remodeling process in patients living with obesity. ANGPTL8 could play a role in improving metabolic homeostasis at early‐term after bariatric surgery offering new insights into adipose ...
Negro EM, Fernández-García P, Martin-Taboada M, Soria-Gondek A, Marín DR, Pérez PC, Cortijo SM, Antolinez MÁ, Mora I, Martínez L, Ros M, Villarroya F, Cereijo R, Sánchez-Infantes D, Corrales P.   +14 more
europepmc   +2 more sources

ANGPTL8 regulates glucose metabolism in gestational diabetes mellitus mice, and proteomic analysis reveals the PI3K/Akt pathway plays its role in insulin-resistance HepG2 cells [PDF]

BMC Pregnancy and Childbirth
Background Insulin resistance (IR) is a pivotal determinant in the pathophysiological processes underlying gestational diabetes mellitus (GDM). Angiopoietin-like protein 8 (ANGPTL8) exhibits an ambiguous influence on glucose metabolism in the onset and ...
Xinping Xie, Jianying Yan, Xiaoyun Chen, Lidan He, Jianbo Wu, Lin Lu   +5 more
doaj   +2 more sources

Nonalcoholic Fatty Liver Disease Exacerbates the Advancement of Renal Fibrosis by Modulating Renal CCR2⁺PIRB⁺ Macrophages Through the ANGPTL8/PIRB/ALOX5AP Axis. [PDF]

Adv Sci (Weinh)
The ANGPTL8/PIRB/ALOX5AP axis mediates liver‐kidney crosstalk. Hepatocytes secrete ANGPTL8, which binds to CCR2+PIRB+ macrophages in the kidneys, affecting the expression of ALOX5AP and enhancing the activation of these macrophages. Activated cells produce TGF‐β, IL‐6, and IL‐23, driving Th17 activation and promote the formation of myofibroblasts ...
Wei S, Shou D, Huang S, Wang Y, Liu Q, Liu J, Lv X, Zeng Y, Wei L, Lin H, Chen J, Chen Y, Zhong H, Zhou Y, Ma W, Wang L, Qian G, Guo J, Sun D.   +18 more
europepmc   +2 more sources

Association between serum ANGPLT8 levels and atherogenic index of plasma in Chinese patients with type 2 diabetes mellitus [PDF]

Frontiers in Cardiovascular Medicine
AimsAngiopoietin-like protein 8 (ANGPTL8), a secreted adipokine, has been reported to be associated with lipid and glucose metabolism. This study aimed to evaluate the association between circulating levels of ANGPTL8 and atherogenic risk, assessed by ...
Xiaoya Sun
doaj   +2 more sources