Results 11 to 20 of about 1,431 (182)
ANGPTL8: An Important Regulator in Metabolic Disorders
Frontiers in Endocrinology, 2018 Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved.
Daoquan Peng, Peng Daoquan
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ANGPTL8 is a negative regulator in pathological cardiac hypertrophy
Cell Death and Disease, 2022 Pathological cardiac hypertrophy is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown.
Lin Hu +12 more
doaj +4 more sources
Journal of Advanced Research, 2023 Introduction: High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD) by promoting chronic inflammation. However, the mechanisms are poorly understood.
Zongli Zhang, Longjun Dai, Jian Tang
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ANGPTL8 in metabolic homeostasis: more friend than foe? [PDF]
Open Biology, 2021 ANGPTL8 is an important cytokine, which is significantly increased in type 2 diabetes mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown that ANGPTL8 can be used as a bio-marker of these metabolic disorders related diseases, and the
Chang Guo, Xia Deng, Jianqiang He
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ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase
Molecular Metabolism, 2017 Objective: Several members of the angiopoietin-like (ANGPTL) family of proteins, including ANGPTL3 and ANGPTL8, regulate lipoprotein lipase (LPL) activity.
Xun Chi +9 more
doaj +4 more sources
Neuropeptide Y-Positive Neurons in the Dorsomedial Hypothalamus Are Involved in the Anorexic Effect of Angptl8 [PDF]
Frontiers in Molecular Neuroscience, 2018 Angiopoietin-like protein 8 (Angptl8), a recently identified member of the angiopoietin-like protein family (ANGPTLs), is a 22-kDa peptide synthesized in the liver.
Rui Wang, Junhua Yuan, Caishun Zhang
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Emerging insights into the roles of ANGPTL8 beyond glucose and lipid metabolism
Frontiers in Physiology, 2023 Angiopoietin-like protein 8 (ANGPTL8) is a secreted protein predominantly expressed in liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by suppressing the activity of lipoprotein lipase (LPL) within the plasma.
Huajie Zou
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The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity [PDF]
Cardiovascular Diabetology, 2018 Background It is well known that angiopoietin-like protein 8 (ANGPTL8) exerts its effects on lipid metabolism through the inhibition of lipoprotein lipase and subsequent elevation of plasma triglyceride.
Mengdie Luo +4 more
doaj +4 more sources
Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway [PDF]
Journal of NeuroinflammationBackground Type 2 diabetes mellitus (T2D) is associated with an increased risk of cognitive dysfunction. Angiopoietin-like protein 8 (ANGPTL8) is an important regulator in T2D, but the role of ANGPTL8 in diabetes-associated cognitive dysfunction remains ...
Xiaoyu Meng +20 more
doaj +3 more sources
Biomedicines, 2022 Sepsis is defined by life-threatening organ dysfunction mediated by the host’s response to infection. This can result in septic dyslipidemia, which is involved in the neutralization of pathogen-related lipids.
Paul Horn +11 more
doaj +5 more sources