Results 51 to 60 of about 9,454 (174)
Environmental Toxicology and Chemistry, EarlyView.Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers +10 more
wiley +1 more source
Journal of Mazandaran University of Medical Sciences, 2019 Background and purpose: Hyperlipidemia is known as one of the major risk factors for cardiovascular disease. Thyme is one of oldest medicinal herbs that is used mainly for medicinal aims.
Samad Akbarzadeh +4 more
doaj
0391 : Molecular mechanisms of ANGPTL4-induced regulation of vascular integrity [PDF]
, 2015 Cardiovascular ischemic injuries are associated with vascular damage induced by loss of endothelial junction integrity. Deciphering the mechanisms involved in the regulation of vascular integrity is of major interest in order to develop relevant ...
Liabotis, Athanasia +7 more
core +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals
Integrative Zoology, EarlyView.This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley +1 more source
Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4
Journal of Lipid Research, 2004 Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to increase plasma triglyceride (TG) levels in vivo.
Hongfei Ge +4 more
doaj +1 more source
Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model
Integrative Zoology, EarlyView.UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang +5 more
wiley +1 more source
ANGPTL4 overexpression is associated with progression and poor prognoses of olfactory neuroblastoma
Diagnostic PathologyObjective To analyze expression levels of angiopoietin‑like 4 (ANGPTL4) in olfactory neuroblastoma (ONB) to investigate the association between ANGPTL4 and ONB.
Yang Yunyun, Li Yahui, Piao Yingshi
doaj +1 more source
, 2015 (A) Immunofluorescence of glomerular Angptl4 in normal, tacrolimus-treated and untreated ADR rats. Scale bars: 50 μm. (B) Quantifications of the fluorescence staining intensities of glomerular Angptl4 in normal, tacrolimus-treated and untreated ADR rats.
Yi-Xin He (371449) +10 more
core +1 more source
Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals
Integrative Zoology, EarlyView.This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong +5 more
wiley +1 more source