Results 71 to 80 of about 8,972 (208)

Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting

Molecular Metabolism, 2017
Objective: Angiopoietin-like 4 (ANGPTL4) is a fasting-induced inhibitor of lipoprotein lipase (LPL) and a regulator of plasma triglyceride metabolism. Here, we examined the kinetics of Angptl4 induction and tested the hypothesis that ANGPTL4 functions ...
Emily M. Cushing, Xun Chi, Kelli L. Sylvers, Shwetha K. Shetty, Matthew J. Potthoff, Brandon S.J. Davies   +5 more
doaj   +1 more source

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, Volume 59, Issue 7, Page 1402-1415, July 2026.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin

Journal of Lipid Research, 2014
Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis.
Taiyi Kuo, Tzu-Chieh Chen, Stephanie Yan, Fritz Foo, Cecilia Ching, Allison McQueen, Jen-Chywan Wang   +6 more
doaj   +1 more source

Putative Genomic Signatures of Local Adaptation in Five Local Indonesian Sheep Reveal Selection on Immunity, Reproduction, and Production Traits

Ecology and Evolution, Volume 16, Issue 6, June 2026.
We determined the genetic structure and signatures of selection in five local Indonesian sheep breeds using genome‐wide SNP data. By integrating population structure analyses with runs of homozygosity and haplotype‐based selection scans, we identified breed‐specific genomic regions associated with immunity, reproduction, pigmentation, metabolism, and ...
Putri Kusuma Astuti, Alexandru Eugeniu Mizeranschi, Herdis Herdis, Pradita Iustitia Sitaresmi, Alek Ibrahim, Sigit Prastowo, Nuzul Widyas, Tristianto Nugroho, Szilvia Kusza   +8 more
wiley   +1 more source

Formin-like 2 beeinflusst ANGPTL4-Sekretion unter TGFbeta-induziertem EMT

, 2020
Epithelial to Mesenchymal transition (EMT) is a highly dynamic process that plays a crucial role in tumor progression and metastasis. While remodelling of the actin cytoskeleton is a hallmark of EMT, the responsible actin regulating factors are less well
Moussi, Christel Jessica
core   +1 more source

Determination of angptl4 mRNA as a diagnostic marker of primary and metastatic clear cell renal-cell carcinoma. [PDF]

PLoS ONE, 2010
BackgroundWe have previously shown that angiopoietin-like 4 (angptl4) mRNA, a hypoxia-inducible gene, is highly expressed in clear cell renal-cell carcinoma (ccRCC), the most common subtype of RCC for which no specific marker is available.
Jérôme Verine, Jacqueline Lehmann-Che, Hany Soliman, Jean-Paul Feugeas, Jean-Sébastien Vidal, Pierre Mongiat-Artus, Stéphanie Belhadj, Josette Philippe, Matthieu Lesage, Evelyne Wittmer, Stéphane Chanel, Anne Couvelard, Sophie Ferlicot, Nathalie Rioux-Leclercq, Jean-Michel Vignaud, Anne Janin, Stéphane Germain   +16 more
doaj   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1987-2002, June 2026.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue [PDF]

, 2012
Background - Lipoprotein lipase (LPL) hydrolyzes triglycerides in lipoproteins and makes fatty acids available for tissue metabolism. The activity of the enzyme is modulated in a tissue specific manner by interaction with other proteins.
Kersten, Sander,, Stienstra, R., Rinke Stienstra, Olivecrona, Thomas,, Mattijssen, Frits,, Sukonina, Valentina,, Stefan K Nilsson, Olivecrona, Gunilla,, Olessia Kroupa, Olivecrona, G., Vorrsjö, E., Stienstra, Rinke,, Kersten, A.H., Evelina Vorrsjö, Gunilla Olivecrona, Frits Mattijssen, Sander Kersten, Valentina Sukonina, Thomas Olivecrona, Nilsson, S.K., Sukonina, V., Olessia Kroupa, Nilsson, Stefan K,, Mattijssen, F.B.J., Kroupa, O., Kroupa, Olessia,, Vorrsjö, Evelina,   +26 more
core   +1 more source

Angiopoietin‐Like Protein 4 Is a High‐Density Lipoprotein (HDL) Component for HDL Metabolism and Function in Nondiabetic Participants and Type‐2 Diabetic Patients

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundANGPTL4 (angiopoietin‐like protein 4) is a LPL (lipoprotein lipase) inhibitor and is present in high‐density lipoprotein (HDL). However, it is not defined whether ANGPTL4 in HDLs could affect HDL metabolism and function in type 2 diabetes ...
Long‐Yan Yang, Cai‐Guo Yu, Xu‐Hong Wang, Sha‐Sha Yuan, Li‐Jie Zhang, Jia‐Nan Lang, Dong Zhao, Ying‐Mei Feng   +7 more
doaj   +1 more source

Ligand‐specific tuning of CLEC10A signalling strength and dendritic cell responses through engagement of different GalNAc‐containing glycan structures

The FEBS Journal, Volume 293, Issue 11, Page 3187-3210, June 2026.
The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs, Remi Hatinguais, Mike de Kok, R. J. Eveline Li, Tesfay M. Godefa, Victor L. J. L. Thijssen, Yvette van Kooyk, Sandra J. van Vliet   +7 more
wiley   +1 more source