Results 61 to 70 of about 8,972 (208)
Oncology Reports, 2011 There is strong evidence that the angiopoietin family is involved in the regulation of tumour progression. Recently, it has been reported that angiopoietin-like 4 (ANGPTL4) expression in cancer cells promotes the metastatic process by increasing vascular permeability.
Toshiyuki, Nakayama +6 more
openaire +3 more sources
Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model
Integrative Zoology, EarlyView.UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang +5 more
wiley +1 more source
Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4
Journal of Lipid Research, 2004 Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to increase plasma triglyceride (TG) levels in vivo.
Hongfei Ge +4 more
doaj +1 more source
Journal of Lipid Research, 2020 Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate
Yan Q. Chen +12 more
doaj +1 more source
Cell Proliferation, EarlyView.During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu +5 more
wiley +1 more source
, 2015 (A) Immunofluorescence of glomerular Angptl4 in normal, tacrolimus-treated and untreated ADR rats. Scale bars: 50 μm. (B) Quantifications of the fluorescence staining intensities of glomerular Angptl4 in normal, tacrolimus-treated and untreated ADR rats.
Yi-Xin He (371449) +10 more
core +1 more source
Proteolytic remodelling of the extracellular matrix by pericytes
The FEBS Journal, EarlyView.Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard +4 more
wiley +1 more source
D016 Angptl4 modulates in vivo developmental and pathological angiogenesis
, 2009 Hypoxia is a potent inducer of angiogenesis during which endothelial cells (ECs) undergo modulations of cell-cell and cell-matrix interactions. ANGPTL4 expression is induced by hypoxia in ECs (1,2) and interacts with the extracellular matrix (3 ...
Germain, S. +3 more
core +1 more source
Journal of Mazandaran University of Medical Sciences, 2019 Background and purpose: Hyperlipidemia is known as one of the major risk factors for cardiovascular disease. Thyme is one of oldest medicinal herbs that is used mainly for medicinal aims.
Samad Akbarzadeh +4 more
doaj
Journal of Internal Medicine, EarlyView.Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Marcello Arca +16 more
wiley +1 more source