Results 81 to 90 of about 9,454 (174)

ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1

Journal of Translational Medicine
Background Ovarian cancer (OC) is a malignant neoplasm that displays increased vascularization. Angiopoietin-like 4 (ANGPTL4) is a secreted glycoprotein that functions as a regulator of cell metabolism and angiogenesis and plays a critical role in ...
Yu-kun Li, An-bo Gao, Tian Zeng, Dan Liu, Qun-feng Zhang, Xiao-min Ran, Zhen-zi Tang, Yan Li, Jue Liu, Ting Zhang, Gang-qing Shi, Wen-chao Zhou, Wen-da Zou, Juan Peng, Juan Zhang, Hui Li, Juan Zou   +16 more
doaj   +1 more source

Predictive Value of Lung Ultrasound Scores Combined with Serum ANGPTL4 Levels on Severity and Prognosis of Neonatal Respiratory Distress Syndrome [PDF]

Liangfu Wang,1 Ping Ji,2 Jiansong Yin,2 Mei Xue,2 Jing Wang,3 Yu Wan,2 Baoqiang Dong4 1Department of Soft Traumatology of Integrated Chinese and Western Medicine, Shenyang Fourth People’s Hospital, Shenyang, Liaoning, 110031, People’s Republic of China ...
Wan Y, Xue M, Ji P, Wang J, Wang L, Yin J, Dong B   +6 more
core  

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi, Weiwei Chen, Kunhao Chen, Song Yang, Sibo Wang, Tongtian Ni, Dan Xu, Enqiang Mao, Erzhen Chen, Ying Chen   +9 more
wiley   +1 more source

Adipocyte‐Derived KIF13B Aggravates Obesity‐Associated Metabolic Dysfunction via LRP1/PPARγ Signaling

MedComm, Volume 7, Issue 10, October 2026.
Adipocyte‐derived KIF13B promotes LRP1 localization and nuclear LRP1–PPARγ transcriptional activity, thereby enhancing adipogenic gene expression, lipid accumulation, and obesity‐associated metabolic dysfunction. Adipocyte‐specific Kif13b deletion disrupts this LRP1/PPARγ axis, suppresses adipogenic programming, reduces adipose expansion, and protects ...
Guolin Miao, Zhaoling Li, Lianxin Zhang, Yitong Xu, Ziwei Wang, Zixun Wang, Aiden Xian, Liwen Zheng, Jingxuan Chen, Yufei Han, Chunhua Shan, Kaikai Lu, Ming Tao, Ling Zhang, Weiguang Zhang, Wei Huang, Yuhui Wang, Rui Wei, Erdan Dong, Xunde Xian   +19 more
wiley   +1 more source

Single‐Cell Mapping Identifies Aging‐Associated Neutrophil Remodeling Across Multiple Organs

Aging Cell, Volume 25, Issue 10, October 2026.
Single‐cell transcriptomic profiling across multiple organs identifies aging reshapes neutrophil differentiation from the bone marrow to peripheral tissues. Computation analysis identifies an age‐enriched Neu06‐IL6 neutrophil state and predicts IL‐6 as one of a candidate regulator for neutrophil remodeling.
Yuman Wang, Teding Chang, Yangguang Fu, Guangyu Liang, Huicheng Liu, Le Zhang, Jinhua Yan, Man Liu, Anding Liu, Cuntai Zhang   +9 more
wiley   +1 more source

Angiopoietin‐like 4 is a potential biomarker for diabetic kidney disease in type 2 diabetes patients

Journal of Diabetes Investigation
Aims/Introduction The association between serum angiopoietin‐like 4 (ANGPTL4) levels and the severity of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus remains unclear.
Yan Wang, Kun Li, Shasha Yuan, Caiguo Yu, Ruili Yin, Di Wang, Yongsong Xu, Lijie Zhang, Lingling Wei, Yanan Cheng, Lin Mao, Dong Zhao, Longyan Yang   +12 more
doaj   +1 more source

The miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy

Journal of Diabetes Investigation, Volume 17, Issue 10, Page 1667-1685, October 2026.
Suppression of miR‐145‐5p alleviates DN‐associated renal tissue damage by inhibiting NRF2/SLC7A11‐mediated ferroptosis of RTECs. ABSTRACT Purpose This study aimed to investigate the molecular mechanism by which the miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell (RTEC) injury in diabetic nephropathy (DN ...
Ganlin Wu, Yu Fang, Meirong Xu, Zuopeng Lu, Yu Cao, Yana Gao   +5 more
wiley   +1 more source

Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its antiangiogenic activity.: CCD mediates angiogenic role of ECM-bound ANGPTL4

, 2009
International audienceAngiopoietin-like 4 (ANGPTL4) is involved in angiogenesis and lipid metabolism. It is secreted by liver and adipose tissues and cleaved to generate circulating coiled-coil domain (CCD) and fibrinogen-like domain (FLD) fragments. The
Muller, Laurent, Faye, Clément, Ardidie, Corinne, Germain, Stéphane, Bignon, Marine, Cazes, Aurélie, Barret, Alain, Monnot, Catherine, Ricard-Blum, Sylvie, Chomel, Clémence, Gomez, Elisa   +10 more
core   +1 more source

ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis.

, 2017
In an ongoing effort to identify molecular determinants regulating melanoma brain metastasis, we previously identified Angiopoietin-like 4 (ANGPTL4) as a component of the molecular signature of such metastases.
Sagi-Assif, Orit, Marzese, Diego M, Ohe, Shuichi, Meshel, Tsipi, Ben-Menachem, Shlomit, Hoon, Dave S B, Witz, Isaac P, Izraely, Sivan, Pasmanik-Chor, Metsada, Zubrilov, Inna   +9 more
core   +1 more source

Expression of Angptl4 in human glomerulonephritis and its relationship with desmin and urine protein.

, 2014
(A) Immunofluorescence of glomerular Angptl4 with synaptopodin in MN patients (magnification, x400). The overlap rate of Angptl4 and synaptopodin was 58.72%.
Jing Ma (24574), Shi-Yao Wei (622760), Rui Cui (622759), Xiao Chen (260187), Bing Li (43671), Qiu-Ju Wei (622761), Lei Peng (260321)   +6 more
core   +1 more source