Results 101 to 110 of about 8,972 (208)

Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its antiangiogenic activity.: CCD mediates angiogenic role of ECM-bound ANGPTL4

, 2009
International audienceAngiopoietin-like 4 (ANGPTL4) is involved in angiogenesis and lipid metabolism. It is secreted by liver and adipose tissues and cleaved to generate circulating coiled-coil domain (CCD) and fibrinogen-like domain (FLD) fragments. The
Muller, Laurent, Faye, Clément, Ardidie, Corinne, Germain, Stéphane, Bignon, Marine, Cazes, Aurélie, Barret, Alain, Monnot, Catherine, Ricard-Blum, Sylvie, Chomel, Clémence, Gomez, Elisa   +10 more
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ANGPTL4 plays a paradoxical role in gastric cancer through the LGALS7 and Hedgehog pathways

Scientific Reports
Gastric cancer (GC) is a malignant disease worldwide. Angiopoietin-like protein 4 (ANGPTL4) plays a role in pathophysiological processes, including metabolic reprogramming, angiogenesis, proliferation, and metastasis.
Juan Xie, Yukun Li, Tian Zeng, Tingyu Fan, Hanguo Shan, Gangqing Shi, Wenchao Zhou, Juan Zou, Xiaoyong Lei   +8 more
doaj   +1 more source

Effects of ANGPTL4 on cell viability and proliferation.

, 2014
ANGPTL4 was added into the culture media alone in order to test its effect on MSCs viability and proliferation. (A and B) Trypan blue assessment indicated that ANGPTL4 alone even up to 1000 ng/mL was not toxic to cultured MSCs.
Jinjin Cui (511760), Rui Jiang (264894), Jingjin Liu (393236), Yongshun Wang (393237), Bo Yu (241082), Kai Liu (159026), Wenhua Liu (393239), Meng Hou (393241), Li Yin (286335), Fang Liu (13271)   +9 more
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Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue

, 2020
Objective: Studies in mice have shown that the decrease in lipoprotein lipase (LPL) activity in adipose tissue upon fasting is mediated by induction of the inhibitor ANGPTL4.
Michielsen, Charlotte C.J.R., Olivecrona, Gunilla, Afman, Lydia A., Olivecrona, Gunilla,, Pirayesh, Ali, Hazebroek, Eric J., Ruppert, Philip M.M., Ruppert, Philip M. M., Michielsen, Charlotte C. J. R., Kersten, Sander   +9 more
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Serum and synovial fluid ANGPTL4 concentrations are elevated in RA.

, 2014
(A) Synovial fluid from RA patients contains more ANGPTL4 (203.3±264.8 ng/ml, range 68.7–847.3 ng/ml) than that from patients with non-inflammatory OA (64.4±13.6 ng/ml, range 50.4–82.2 ng/ml ...
Nicholas A. Athanasou (632663), Helen J. Knowles (640983), Catherine Swales (640982)   +2 more
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Model of ANGPTL4 gene regulation and higher-order chromatin in cells treated with Dex.

, 2017
In its basal state, ANGPTL4 is not activated in the absence of Dex-bound GR within the preexisting higher-order chromatin structure. When ANGPTL4 is transcriptionally active (Dex 3 h), liganded GR binds to AG sites and enhances interactions between ...
Masafumi Nakamoto (3617828), Mitsuyoshi Nakao (12822), Akiyuki Hirosue (3439931), Shinjiro Hino (3617834), Hideki Nakayama (2601604), Takehisa Watanabe (3617837), Ko Ishihara (3617831), Masanori Shinohara (3617840)   +7 more
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Plasma angiopoietin-like protein 4 as a novel biomarker predicting 10-year mortality in a community-based population: a longitudinal cohort study

Archives of Medical Science
Introduction Angiopoietin-like protein 4 (ANGPTL4) is a hepatokine implicated in fat metabolism regulation. Its genetic inactivation has been associated with improved glucose homeostasis, while elevated plasma ANGPTL4 levels are observed in diabetic and ...
Kang-Chih Fan, Szu-Chi Chen, I-Weng Yen, Chia-Hung Lin, Chun-Heng Kuo, Ya-Pin Lyu, Hsien-Chia Juan, Mao-Shin Lin, Shu-Huei Wang, Hung-Yuan Li   +9 more
doaj   +1 more source

ANGPTL4 protected MSCs from hypoxia/SD-induced apoptosis.

, 2014
Apoptosis was measured by flow cytometry and TUNEL assay in MSCs pre-incubated with ANGPTL4 (100 ng/mL) for 1 hr, and then either kept (ANGPTL4 Pre-1 hr +24 hr) or removed (ANGPTL4 Pre-1 hr) during a 24 hr hypoxia/SD condition.
Jinjin Cui (511760), Rui Jiang (264894), Jingjin Liu (393236), Yongshun Wang (393237), Bo Yu (241082), Kai Liu (159026), Wenhua Liu (393239), Meng Hou (393241), Li Yin (286335), Fang Liu (13271)   +9 more
core   +1 more source

Increase in Angptl4 expression in human MCD patients and associations with desmin, synaptopodin and proteinuria.

, 2015
(A and B) Immunofluorescence of glomerular Angptl4 and desmin in MCD and MsPGN patients with similar nephrotic-range proteinuria (magnification, 200X).
Yi-Xin He (371449), Shi-Yao Wei (622760), Tian-Tian Diao (793328), Xiao Chen (260187), Qing-Fang Zhang (793329), Jian-Si Li (793326), Bing Li (43671), Shi-Lei Zhao (793327), Qiu-Ju Wei (622761), Lei Peng (260321), Fang Liu (13271)   +10 more
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Functional characterization of Angptl4 protein

Background: Elevated plasma triglycerides (TG) are increasingly recognized as a risk factor for atherosclerosis. A new adipocytokine was discovered by several groups which is referred to as Angptl4 (Angiopoietin-like protein 4). Angptl4 was recently identified as a major determinant of plasma TG levels in mice.
openaire   +2 more sources