Results 11 to 20 of about 8,972 (208)

Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice[S] [PDF]

Journal of Lipid Research, 2019
Angiopoietin-like protein (ANGPTL)4 regulates plasma lipids, making it an attractive target for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet causes chylous ascites, an acute-phase response, and mesenteric ...
Antwi-Boasiako Oteng, PhilipM.M. Ruppert, Lily Boutens, Wieneke Dijk, XantheA.M.H. van Dierendonck, Gunilla Olivecrona, Rinke Stienstra, Sander Kersten   +7 more
doaj   +7 more sources

ANGPTL4: A Predictive Marker for Diabetic Nephropathy [PDF]

Journal of Diabetes Research, 2019
Background. ANGPTL4 is a glycoprotein that is involved in regulating triglyceride metabolism by inhibiting LPL activity under fasting conditions. Additionally, ANGPTL4 has been suggested as a link between hypertriglyceridemia and albuminuria in the ...
Eman Al Shawaf, Mohamed Abu-Farha, Sriraman Devarajan, Zahra Alsairafi, Irina Al-Khairi, Preethi Cherian, Hamad Ali, Aditi Mathur, Fahd Al-Mulla, Abdulnabi Al Attar, Jehad Abubaker   +10 more
doaj   +4 more sources

Angiopoietin-like 4 (Angptl4) [PDF]

, 2012
Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting.
Koliwad, Suneil K, Wang, Jen-Chywan, Gray, Nora E   +2 more
core   +4 more sources

Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity

Heliyon, 2021
We previously demonstrated that angiopoietin-like protein 8 (ANGPTL8) forms ANGPTL3/8 and ANGPTL4/8 complexes that increase with feeding to direct fatty acids (FA) toward adipose tissue through differential modulation of lipoprotein lipase (LPL) activity.
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Robert J. Konrad   +5 more
doaj   +2 more sources

Regulation of Lipoprotein Lipase by Angptl4

Trends in Endocrinology & Metabolism, 2014
Triglyceride (TG)-rich chylomicrons and very low density lipoproteins (VLDL) distribute fatty acids (FA) to various tissues by interacting with the enzyme lipoprotein lipase (LPL).
Kersten, A.H., Dijk, W.
core   +4 more sources

ANGPTL4 suppresses progression and improves cisplatin sensitivity in cervical cancer

Scientific Reports
Cervical cancer (CC) remains a leading cause of cancer-related deaths worldwide and still requires effective interventions to improve patient outcomes.
Waraporn Chan-on, Methawadee Turinthorn, Arkom Chaiwongkot, Teerasit Techawiwattanaboon, Prasong Khaenam, Chaniya Leepiyasakulchai   +5 more
doaj   +2 more sources

ANGPTL4 May Regulate the Crosstalk Between Intervertebral Disc Degeneration and Type 2 Diabetes Mellitus: A Combined Analysis of Bioinformatics and Rat Models

Journal of Inflammation Research, 2023
Yan Chen,1,* Han Du,1,* Xin Wang,1,* Baixing Li,1 Xuzhuo Chen,2 Xiao Yang,1 Changqing Zhao,1 Jie Zhao1 1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong ...
Chen Y, Du H, Wang X, Li B, Chen X, Yang X, Zhao C, Zhao J   +7 more
doaj   +1 more source

ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis.

Oncotarget, 2017
In an ongoing effort to identify molecular determinants regulating melanoma brain metastasis, we previously identified Angiopoietin-like 4 (ANGPTL4) as a component of the molecular signature of such metastases.
Sagi-Assif, Orit, Marzese, Diego M, Ohe, Shuichi, Meshel, Tsipi, Ben-Menachem, Shlomit, Hoon, Dave S B, Witz, Isaac P, Izraely, Sivan, Pasmanik-Chor, Metsada, Zubrilov, Inna   +9 more
core   +4 more sources

Structures of Angptl3 and Angptl4 [PDF]

Scientific Reports, 2020
Coronary artery disease is the most common cause of death globally and is linked to a number of risk factors including serum low density lipoprotein, high density lipoprotein, triglycerides and lipoprotein(a). Recently two proteins, angiopoietin-like protein 3 and 4, have emerged from genetic studies as being factors that significantly modulate plasma ...
Biterova, Ekaterina, Esmaeeli Moghaddam Tabalvandani, Mariam, Alanen, Heli I., Saaranen, Mirva, Ruddock, Lloyd W.   +4 more
openaire   +6 more sources

Regulation of fat partitioning by ANGPTL4

The FASEB Journal, 2021
Altered triglyceride metabolism and changes in fatty acid partitioning are major contributors to metabolic diseases including metabolic syndrome, diabetes, and atherosclerosis. The triglycerides in plasma lipoproteins are hydrolyzed by lipoprotein lipase (LPL), and the levels of LPL activity in the capillary beds of peripheral tissues such as heart ...
Brandon Davies, Kathryn Spitler
openaire   +1 more source