Results 11 to 20 of about 9,454 (174)

Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice[S] [PDF]

Journal of Lipid Research, 2019
Angiopoietin-like protein (ANGPTL)4 regulates plasma lipids, making it an attractive target for correcting dyslipidemia. However, ANGPTL4 inactivation in mice fed a high fat diet causes chylous ascites, an acute-phase response, and mesenteric ...
Antwi-Boasiako Oteng, PhilipM.M. Ruppert, Lily Boutens, Wieneke Dijk, XantheA.M.H. van Dierendonck, Gunilla Olivecrona, Rinke Stienstra, Sander Kersten   +7 more
doaj   +2 more sources

ANGPTL4: A Predictive Marker for Diabetic Nephropathy

Journal of Diabetes Research, 2019
Background. ANGPTL4 is a glycoprotein that is involved in regulating triglyceride metabolism by inhibiting LPL activity under fasting conditions. Additionally, ANGPTL4 has been suggested as a link between hypertriglyceridemia and albuminuria in the ...
Eman Al Shawaf, Mohamed Abu-Farha, Sriraman Devarajan, Zahra Alsairafi, Irina Al-Khairi, Preethi Cherian, Hamad Ali, Aditi Mathur, Fahd Al-Mulla, Abdulnabi Al Attar, Jehad Abubaker   +10 more
doaj   +2 more sources

Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity

Heliyon, 2021
We previously demonstrated that angiopoietin-like protein 8 (ANGPTL8) forms ANGPTL3/8 and ANGPTL4/8 complexes that increase with feeding to direct fatty acids (FA) toward adipose tissue through differential modulation of lipoprotein lipase (LPL) activity.
Yan Q. Chen, Thomas G. Pottanat, Robert W. Siegel, Mariam Ehsani, Yue-Wei Qian, Robert J. Konrad   +5 more
doaj   +2 more sources

ANGPTL4 May Regulate the Crosstalk Between Intervertebral Disc Degeneration and Type 2 Diabetes Mellitus: A Combined Analysis of Bioinformatics and Rat Models

Journal of Inflammation Research, 2023
Yan Chen,1,* Han Du,1,* Xin Wang,1,* Baixing Li,1 Xuzhuo Chen,2 Xiao Yang,1 Changqing Zhao,1 Jie Zhao1 1Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong ...
Chen Y, Du H, Wang X, Li B, Chen X, Yang X, Zhao C, Zhao J   +7 more
doaj   +1 more source

ANGPTL4 suppresses progression and improves cisplatin sensitivity in cervical cancer

Scientific Reports
Cervical cancer (CC) remains a leading cause of cancer-related deaths worldwide and still requires effective interventions to improve patient outcomes.
Waraporn Chan-on, Methawadee Turinthorn, Arkom Chaiwongkot, Teerasit Techawiwattanaboon, Prasong Khaenam, Chaniya Leepiyasakulchai   +5 more
doaj   +2 more sources

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function. [PDF]

Adv Sci (Weinh)
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Liu X, Jiang S, Yang Z, Shang S, Li J, Zou G, Zhou C, Li W.   +7 more
europepmc   +2 more sources

Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. [PDF]

PLoS ONE, 2012
Peroxisome proliferator-activated receptor (PPAR) delta is an important regulator of fatty acid (FA) metabolism. Angiopoietin-like 4 (Angptl4), a multifunctional protein, is one of the major targets of PPAR delta in skeletal muscle cells.
Marius R Robciuc, Paulina Skrobuk, Andrey Anisimov, Vesa M Olkkonen, Kari Alitalo, Robert H Eckel, Heikki A Koistinen, Matti Jauhiainen, Christian Ehnholm   +8 more
doaj   +1 more source

Angiopoietin-like 4-Induced 3D Capillary Morphogenesis Correlates to Stabilization of Endothelial Adherens Junctions and Restriction of VEGF-Induced Sprouting

Biomedicines, 2022
Angiopoietin-like 4 (ANGPTL4) is a target of hypoxia that accumulates in the endothelial extracellular matrix. While ANGPTL4 is known to regulate angiogenesis and vascular permeability, its context-dependent role related to vascular endothelial growth ...
Athanasia Liabotis, Corinne Ardidie-Robouant, Philippe Mailly, Samaher Besbes, Charly Gutierrez, Yoann Atlas, Laurent Muller, Stéphane Germain, Catherine Monnot   +8 more
doaj   +1 more source

Angiopoietin-like 4 (Angptl4) [PDF]

, 2012
Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting.
Koliwad, Suneil K, Wang, Jen-Chywan, Gray, Nora E   +2 more
core   +1 more source

‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion

, 2023
Vesicle trafficking has emerged as an important process driving tumor progression through various mechanisms. Transforming growth factor beta (TGFβ)-mediated secretion of Angiopoietin-like 4 (ANGPTL4) is important for cancer development.
Svenja Ulferts, Carsten Schwan, Schwan, Carsten, Frank, Dennis, Lorenzen, Lina, Grosse, Robert, Christel Jessica Moussi, Lina Lorenzen, Ulferts, Svenja, Dennis Frank, Moussie, Jessica Christel, Robert Grosse   +11 more
core   +1 more source