Results 21 to 30 of about 8,972 (208)

ANGPTL4 suppresses the profibrogenic functions of atrial fibroblasts induced by angiotensin II by up-regulating PPARγ [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): The present study’s objective was to investigate the association between angiopoietin-like 4 (ANGPTL4) levels and the prognosis of Atrial fibrillation (AF), the causative effect in angiotensin II- (Ang II) induced AF, and its underlying ...
Xi Zhu, Xiaogang Zhang, Wei Gu, Hanjun Zhao, Shuwen Hao, Zhongping Ning   +5 more
doaj   +1 more source

Angiopoietin-like 4 promotes epidermal stem cell proliferation and migration and contributes to cutaneous wound re-epithelialization

Acta Biochimica et Biophysica Sinica, 2023
Proliferation and migration of epidermal stem cells (EpSCs) are essential for epithelialization during skin wound healing. Angiopoietin-like 4 (ANGPTL4) has been reported to play an important role in wound healing, but the mechanisms involved are not ...
Yang Yuan, Yu Chenghao, Le Yingying, Gong Weijuan, Ju Jihui, Zhang Guangliang, Ji Pengxiang, Zuo Rui, Liu Zhe, Zhang Ping, Hou Ruixing, Fu Yi   +11 more
doaj   +1 more source

ANGPTL4 functions as an oncogene through regulation of the ETV5/CDH5/AKT/MMP9 axis to promote angiogenesis in ovarian cancer

Journal of Ovarian Research, 2022
Background Angiopoietin-like 4 (ANGPTL4) is highly expressed in a variety of neoplasms and promotes cancer progression. Nevertheless, the mechanism of ANGPTL4 in ovarian cancer (OC) metastasis remains unclear. This study aimeds to explore whether ANGPTL4
Yinping Liu, Rui Yang, Yan Zhang, Yaping Zhu, Wei Bao   +4 more
doaj   +1 more source

Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes. [PDF]

PLoS ONE, 2012
Peroxisome proliferator-activated receptor (PPAR) delta is an important regulator of fatty acid (FA) metabolism. Angiopoietin-like 4 (Angptl4), a multifunctional protein, is one of the major targets of PPAR delta in skeletal muscle cells.
Marius R Robciuc, Paulina Skrobuk, Andrey Anisimov, Vesa M Olkkonen, Kari Alitalo, Robert H Eckel, Heikki A Koistinen, Matti Jauhiainen, Christian Ehnholm   +8 more
doaj   +1 more source

Angiopoietin-like 4-Induced 3D Capillary Morphogenesis Correlates to Stabilization of Endothelial Adherens Junctions and Restriction of VEGF-Induced Sprouting

Biomedicines, 2022
Angiopoietin-like 4 (ANGPTL4) is a target of hypoxia that accumulates in the endothelial extracellular matrix. While ANGPTL4 is known to regulate angiogenesis and vascular permeability, its context-dependent role related to vascular endothelial growth ...
Athanasia Liabotis, Corinne Ardidie-Robouant, Philippe Mailly, Samaher Besbes, Charly Gutierrez, Yoann Atlas, Laurent Muller, Stéphane Germain, Catherine Monnot   +8 more
doaj   +1 more source

The Study of Angptl4-Modulated Podocyte Injury in IgA Nephropathy [PDF]

Frontiers in Physiology, 2021
BackgroundIncreasing evidence shows that Angptl4 affects proteinuria in podocytes injured kidney disease, however, whether there is a relationship between Angptl4 and IgA nephropathy (IgAN) has not been studied yet.MethodsPlasma and urine samples were obtained from 71 patients with IgAN and 61 healthy controls. Glomeruli from six renal biopsy specimens
Sha Jia, Sha Jia, Sha Jia, Sha Jia, Sha Jia, Sha Jia, Xiaofeng Peng, Xiaofeng Peng, Xiaofeng Peng, Xiaofeng Peng, Xiaofeng Peng, Ludan Liang, Ludan Liang, Ludan Liang, Ludan Liang, Ludan Liang, Ying Zhang, Ying Zhang, Ying Zhang, Ying Zhang, Ying Zhang, Meng Li, Meng Li, Meng Li, Meng Li, Meng Li, Qin Zhou, Qin Zhou, Qin Zhou, Qin Zhou, Qin Zhou, Xiujin Shen, Xiujin Shen, Xiujin Shen, Xiujin Shen, Xiujin Shen, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Yucheng Wang, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Cuili Wang, Shi Feng, Shi Feng, Shi Feng, Shi Feng, Shi Feng, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Jianghua Chen, Pingping Ren, Pingping Ren, Pingping Ren, Pingping Ren, Pingping Ren, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang, Hong Jiang   +65 more
openaire   +3 more sources

Meningitic Escherichia coli Induction of ANGPTL4 in Brain Microvascular Endothelial Cells Contributes to Blood–Brain Barrier Disruption via ARHGAP5/RhoA/MYL5 Signaling Cascade

Pathogens, 2019
Bacterial meningitis is currently recognized as one of the most important life-threatening infections of the central nervous system (CNS) with high morbidity and mortality, despite the advancements in antimicrobial treatment.
Lu Liu, Jixuan Li, Dong Huo, Zhong Peng, Ruicheng Yang, Jiyang Fu, Bojie Xu, Bo Yang, Huanchun Chen, Xiangru Wang   +9 more
doaj   +1 more source

Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4

Genes and Diseases, 2022
Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen, Chunhua Weng, Yucheng Wang, Cuili Wang, Shi Feng, Xiayu Li, Heng Li, Hong Jiang, Haibing Wang, Jianghua Chen   +9 more
doaj   +1 more source

‐Induced ANGPTL4 Trafficking, Secretion and Cell Invasion

, 2023
Vesicle trafficking has emerged as an important process driving tumor progression through various mechanisms. Transforming growth factor beta (TGFβ)-mediated secretion of Angiopoietin-like 4 (ANGPTL4) is important for cancer development.
Svenja Ulferts, Carsten Schwan, Schwan, Carsten, Frank, Dennis, Lorenzen, Lina, Grosse, Robert, Christel Jessica Moussi, Lina Lorenzen, Ulferts, Svenja, Dennis Frank, Moussie, Jessica Christel, Robert Grosse   +11 more
core   +1 more source

ANGPTL4 in Metabolic and Cardiovascular Disease

Trends in Molecular Medicine, 2019
Alterations in circulating lipids and ectopic lipid deposition impact on the risk of developing cardiovascular and metabolic diseases. Lipoprotein lipase (LPL) hydrolyzes fatty acids (FAs) from triglyceride (TAG)-rich lipoproteins including very low density lipoproteins (VLDLs) and chylomicrons, and regulates their distribution to peripheral tissues ...
Binod, Aryal, Nathan L, Price, Yajaira, Suarez, Carlos, Fernández-Hernando   +3 more
openaire   +3 more sources