Results 21 to 30 of about 9,454 (174)
Pathogens, 2019 Bacterial meningitis is currently recognized as one of the most important life-threatening infections of the central nervous system (CNS) with high morbidity and mortality, despite the advancements in antimicrobial treatment.
Lu Liu +9 more
doaj +1 more source
Genes and Diseases, 2022 Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen +9 more
doaj +1 more source
Inactivation of oligomeric LPL by ANGPTL4.
, 2023 20 nM LPL (A) or 200 nM LPL (B) was incubated in the presence of 1 μM ANGPTL4 and 10 IU/ml heparin (●) or 50 mg/ml BSA (■) or both (▼) in buffer A. Remaining LPL activity was determined by ITC using undiluted pooled human plasma (0.89 mM triglycerides, n
Kristofer Hiis-Hommuk (15213709) +8 more
core +1 more source
BMC Cancer, 2018 Background Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor prognosis.
T. Zhang +4 more
doaj +1 more source
Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes
Journal of Lipid Research, 2016 LPL hydrolyzes triglycerides in triglyceride-rich lipoproteins along the capillaries of heart, skeletal muscle, and adipose tissue. The activity of LPL is repressed by angiopoietin-like 4 (ANGPTL4) but the underlying mechanisms have not been fully ...
Wieneke Dijk +5 more
doaj +1 more source
The Glucocorticoid Receptor Regulates the ANGPTL4 Gene in a CTCF-Mediated Chromatin Context in Human Hepatic Cells. [PDF]
PLoS ONE, 2017 Glucocorticoid signaling through the glucocorticoid receptor (GR) plays essential roles in the response to stress and in energy metabolism. This hormonal action is integrated to the transcriptional control of GR-target genes in a cell type-specific and ...
Masafumi Nakamoto +7 more
doaj +1 more source
Role of Angiopoietin-like protein 4 (ANGPTL4) as a Predictive marker for Diabetic Nephropathy in type 2 Diabetes [PDF]
Al-Azhar International Medical Journal, 2022 Background: Angiopoietin-like protein 4 (ANGPTL4) is a glycoprotein that regulates LPL activity during fasting and thereby affects triglyceride metabolism.
Amr Rezk +3 more
doaj +1 more source
Journal of Lipid Research, 2011 Animal studies have suggested that angiopoietin-like 4 (Angptl4) regulates adiposity through central and peripheral mechanisms. The aim of this study was to investigate whether serum concentration and adipose tissue expression of Angptl4 are associated ...
Marius R. Robciuc +9 more
doaj +1 more source
Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis
Nature Communications, 2023 Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic homeostasis remains to be elucidated.
Balkrishna Chaube +11 more
doaj +1 more source
D016 Angptl4 modulates in vivo developmental and pathological angiogenesis [PDF]
, 2009 Hypoxia is a potent inducer of angiogenesis during which endothelial cells (ECs) undergo modulations of cell-cell and cell-matrix interactions. ANGPTL4 expression is induced by hypoxia in ECs (1,2) and interacts with the extracellular matrix (3 ...
Germain, S. +3 more
core +1 more source