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Lipoprotein metabolism indicators improve cardiovascular risk prediction. [PDF]
PLoS ONE, 2014 BACKGROUND: Cardiovascular disease risk increases when lipoprotein metabolism is dysfunctional. We have developed a computational model able to derive indicators of lipoprotein production, lipolysis, and uptake processes from a single lipoprotein profile
Daniël B van Schalkwijk +7 more
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Lipoprotein metabolism in familial hypercholesterolemia [PDF]
Journal of Lipid Research, 2021 Familial hypercholesterolemia (FH) is one of the most common genetic disorders in humans. It is an extremely atherogenic metabolic disorder characterized by lifelong elevations of circulating LDL-C levels often leading to premature cardiovascular events.
Kévin Chemello +5 more
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A computational model for the analysis of lipoprotein distributions in the mouse: translating FPLC profiles to lipoprotein metabolism. [PDF]
PLoS Computational Biology, 2014 Disturbances of lipoprotein metabolism are recognized as indicators of cardiometabolic disease risk. Lipoprotein size and composition, measured in a lipoprotein profile, are considered to be disease risk markers.
Fianne L P Sips +5 more
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Causal associations between disorders of lipoprotein metabolism and ten cardiovascular diseases [PDF]
Frontiers in Cell and Developmental Biology, 2022 Disorders of lipoprotein metabolism have been linked with an increased risk of cardiovascular diseases (CVDs) but the causal association is unclear. In this study, we investigated the causal association between disorders of lipoprotein metabolism and ...
Qiannan Gao +5 more
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Lipoprotein metabolism in experimental nephrosis
Journal of Lipid Research, 1984 In experimental nephrosis, a decrease in plasma albumin resulting from proteinuria causes a decreased in the plasma oncotic pressure. The existence of an osmoreceptor, which responds to the low oncotic pressure and produces a factor(s) that signals the liver to increase the secretion of plasma proteins, is postulated.
J B Marsh
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Intestinal lipoprotein metabolism
Journal of Lipid Research, 1981 P H Green, R M Glickman
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A Simple Fluorescent Cholesterol Labeling Method to Cryoprotect and Detect Plasma Lipoprotein-X
Biology, 2022 Lipoprotein-X (LpX) are abnormal nephrotoxic lipoprotein particles enriched in free cholesterol and phospholipids. LpX with distinctive lipid compositions are formed in patients afflicted with either familial LCAT deficiency (FLD) or biliary cholestasis.
Edward B. Neufeld +6 more
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Apolipoprotein Mimetic Peptides: Potential New Therapies for Cardiovascular Diseases
Cells, 2021 Since the seminal breakthrough of treating diabetic patients with insulin in the 1920s, there has been great interest in developing other proteins and their peptide mimetics as therapies for a wide variety of other medical disorders. Currently, there are
Anna Wolska +4 more
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Frontiers in Cardiovascular Medicine, 2023 IntroductionDefects in lipolysis can lead to hypertriglyceridemia, which can trigger acute pancreatitis and is also associated with cardiovascular disease.
Denis Sviridov +8 more
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A new phenotypic classification system for dyslipidemias based on the standard lipid panel
Lipids in Health and Disease, 2021 Highlights A new algorithm is described for categorizing dyslipidemic patients into Fredrickson-like lipoprotein phenotypes except for Type III. The new lipoprotein phenotypes were validated by NMR-lipoprotein analysis and by agarose gel electrophoresis ...
Maureen Sampson +15 more
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