Results 41 to 50 of about 1,213,965 (250)

Lipoprotein metabolism in familial hypercholesterolemia

Journal of Lipid Research, 2021
Familial hypercholesterolemia (FH) is one of the most common genetic disorders in humans. It is an extremely atherogenic metabolic disorder characterized by lifelong elevations of circulating LDL-C levels often leading to premature cardiovascular events.
Kévin Chemello, Javier García-Nafría, Antonio Gallo, Cesar Martín, Gilles Lambert, Dirk Blom   +5 more
doaj   +1 more source

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Peter Fraunberger, Karl Werdan, Werdan, Karl, Walli, Autar K., Autar K. Walli, Dietrich Seidel, Seidel, Dietrich, Steffen Schaefer, Fraunberger, Peter, Schaefer, Steffen   +9 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Inhibition of cholesterol absorption associated with a PPARα-dependent increase in ABC binding cassette transporter A1 in mice

Journal of Lipid Research, 2003
Dietary supplementation with the peroxisome proliferator-activated receptor α (PPARα) ligand WY 14,643 gave rise to a 4- to 5-fold increase in the expression of mRNA for the ATP binding cassette transporter A1 (ABCA1) in the intestine of normal mice ...
Brian L. Knight, Dilip D. Patel, Sandy M. Humphreys, David Wiggins, Geoffrey F. Gibbons   +4 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Lipoprotein metabolism : Lipoprotein lipase and Hepatic lipase [PDF]

, 1992
P(論文)Lipoprotein lipase and hepatic lipase are thought to play an important role in chylomicron and very low density lipoprotein metabolism and in high- and intermediate- density lipoprotein metabolism, respectively.
森田, 哲生, 金川, 麻子, 32825, 32823, 植木, 寛, 32824   +5 more
core   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Recent Advances in Targeted Management of Inflammation In Atherosclerosis: A Narrative Review

Cardiology and Therapy
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality despite effective low-density lipoprotein cholesterol-targeted therapies.
Rafael Zubirán, Edward B. Neufeld, Amaury Dasseux, Alan T. Remaley, Alexander V. Sorokin   +4 more
doaj   +1 more source

Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period

Journal of Lipid Research, 2003
Circulating triacylglycerol (TG) arises mainly from dietary fat. However, little is known about the entry of dietary fat into the major TG pool, very low-density lipoprotein (VLDL) TG. We used a novel method to study the specific incorporation of dietary
Richard B. Heath, Fredrik Karpe, Ross W. Milne, Graham C. Burdge, Stephen A. Wootton, Keith N. Frayn   +5 more
doaj   +1 more source

Targeting Lipid Rafts—A Potential Therapy for COVID-19

Frontiers in Immunology, 2020
COVID-19 is a global pandemic currently in an acute phase of rapid expansion. While public health measures remain the most effective protection strategy at this stage, when the peak passes, it will leave in its wake important health problems ...
Dmitri Sviridov, Dmitri Sviridov, Yury I. Miller, Rami A. Ballout, Alan T. Remaley, Michael Bukrinsky   +5 more
doaj   +1 more source