Results 51 to 60 of about 244,000 (301)

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Recent Advances in Targeted Management of Inflammation In Atherosclerosis: A Narrative Review

Cardiology and Therapy
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of morbidity and mortality despite effective low-density lipoprotein cholesterol-targeted therapies.
Rafael Zubirán, Edward B. Neufeld, Amaury Dasseux, Alan T. Remaley, Alexander V. Sorokin   +4 more
doaj   +1 more source

Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period

Journal of Lipid Research, 2003
Circulating triacylglycerol (TG) arises mainly from dietary fat. However, little is known about the entry of dietary fat into the major TG pool, very low-density lipoprotein (VLDL) TG. We used a novel method to study the specific incorporation of dietary
Richard B. Heath, Fredrik Karpe, Ross W. Milne, Graham C. Burdge, Stephen A. Wootton, Keith N. Frayn   +5 more
doaj   +1 more source

Targeting Lipid Rafts—A Potential Therapy for COVID-19

Frontiers in Immunology, 2020
COVID-19 is a global pandemic currently in an acute phase of rapid expansion. While public health measures remain the most effective protection strategy at this stage, when the peak passes, it will leave in its wake important health problems ...
Dmitri Sviridov, Dmitri Sviridov, Yury I. Miller, Rami A. Ballout, Alan T. Remaley, Michael Bukrinsky   +5 more
doaj   +1 more source

New insights into the role of glycosylation in lipoprotein metabolism

, 2017
Purpose of reviewHuman genetics has provided new insights into the role of protein glycosylation in regulating lipoprotein metabolism. Here we review these new developments and discuss the biological insights they provide.Recent findingsCase descriptions
Marjolein A.W. van den Boogert, Holleboom, Adriaan G., Daniel J. Rader, Adriaan G. Holleboom, van den Boogert, Marjolein A. W., Rader, Daniel J.   +5 more
core   +1 more source

Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty‐one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI.
Jihyun Park, Emily J. Koubek, Richard Beare, Lynn Ang, Brian C. Callaghan, Rodica Pop‐Busui, Eva L. Feldman, Evan L. Reynolds   +7 more
wiley   +1 more source

Reverse cholesterol transport: current assay methods, alterations with disease and response to therapeutic intervention

Frontiers in Cardiovascular Medicine
The removal of excess cholesterol from the body by High-density lipoprotein (HDL) in a process termed reverse cholesterol transport (RCT) has long been proposed to play a critical role in reduction of the lipid burden in arterial wall atherosclerotic ...
Martin P. Playford, Edward B. Neufeld, Rafael Zubirán, Alan T. Remaley   +3 more
doaj   +1 more source

Scavenger receptor-BI is a receptor for lipoprotein(a)

Journal of Lipid Research, 2013
Scavenger receptor class B type I (SR-BI) is a multi-ligand receptor that binds a variety of lipoproteins, including high density lipoprotein (HDL) and low density lipoprotein (LDL), but lipoprotein(a) [Lp(a)] has not been investigated as a possible ...
Xiao-Ping Yang, Marcelo J. Amar, Boris Vaisman, Alexander V. Bocharov, Tatyana G. Vishnyakova, Lita A. Freeman, Roger J. Kurlander, Amy P. Patterson, Lewis C. Becker, Alan T. Remaley   +9 more
doaj   +1 more source

A Role of the Bile Salt Receptor FXR in Atherosclerosis

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Albert K. Groen, Hageman, Jurre, Herrema, H.J., Folkert Kuipers, Hageman, J., Kuipers, Folkert, Herrema, Hilde, Hilde Herrema, Kuipers, Folkert; id_orcid, Groen, A.K., Kuipers, F., Groen, Albert K., Jurre Hageman   +12 more
core   +1 more source

Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome [PDF]

, 2011
Background Our objective was to find single nucleotide polymorphisms (SNPs), within transcriptional pathways of glucose and lipid metabolism, which are related to multiple features of the metabolic syndrome (MetS).
Boer, J.M., Dollé Martijn ET, Boer Jolanda MA, Feskens Edith JM, Martijn ET Dollé, Edith JM Feskens, Imholz, S., Feskens, E.J.M., Sandra Imholz, Povel, C.M., Cécile M Povel, Jolanda MA Boer, Imholz Sandra, Povel Cécile M, Dolle, M.E.   +14 more
core   +1 more source