Results 71 to 80 of about 1,213,965 (250)

ApoA-I Dissociated From Human HDL Retains its Acceptor Properties in ABCA1-mediated Cholesterol Efflux From RAW 264.7 Macrophages in Coronary Artery Disease

Frontiers in Bioscience-Landmark
Background: The significance of cholesterol efflux as a predictor of coronary artery disease (CAD) remains controversial. The intracellular cholesterol export via the ABCA1 transporter involves the acceptance of cholesterol by both ...
Veronika B. Baserova, Mikhail A. Popov, Alexander D. Dergunov   +2 more
doaj   +1 more source

Italian Multicenter Study on Low-Density Lipoprotein Apheresis Working Group 2009 Survey

, 2013
We present results of the second survey of the Italian Multicenter Study on Low-Density Lipoprotein Apheresis (IMSLDLa-WG/2). The study involved 18 centers in 2009, treating 66 males and 35 females, mean age 47 +/- 18 years.
MOROZZI, CLAUDIA, STEFANUTTI, Claudia, DI GIACOMO, SERAFINA, The Italian Multicenter Study O. N. Low Density Lipoprotein Apheresis Working Group   +3 more
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Antioxidants and lipoprotein metabolism

, 1999
Lipoprotein metabolism plays a significant role in the pathogenesis of atherosclerosis and risk of vascular disease. Elevated levels of LDL and low levels of HDL are linked to the risk of cardiovascular disease.
David I. Thurnham, Mridula Chopra
core   +1 more source

Changes in the Plasma Lipid Profile as a Potential Predictor of Clinical Outcome in Dengue Hemorrhagic Fever [PDF]

, 2002
In 50 consecutive children admitted to the intensive care unit with the clinical diagnosis of dengue hemorrhagic fever (DHF)/dengue shock syndrome (grade III or IV), 20 patients with mild DHF (grade I or II), and 20 healthy control patients, the plasma ...
Suharti, C., Gorp, E. van, van der Meer, Jos W. M., Dolmans, Wil M. V., Meer, J.W.M. van der, Mairuhu, A.T., van der Ven-Jongekrijg, Johanna, Ven-Jongekrijg, J. van der, Demacker, P.N.M., Dolmans, W.M.V., Mairuhu, A.T.A., Mairuhu, ATA, Ven, J. van der, Suharti, Catharina, van Gorp, Eric C. M., Demacker, Pierre N M, Gorp, E.C.M. van   +16 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Experimental Therapeutics for Challenging Clinical Care of a Patient with an Extremely Rare Homozygous APOC2 Mutation

Case Reports in Endocrinology, 2020
Background. Among many causes of hypertriglyceridemia (HTG), familial chylomicronemia syndrome (FCS) is a rare monogenic disorder that manifests as severe HTG and acute pancreatitis.
Masako Ueda, Anna Wolska, Frances M. Burke, Maria Escobar, Laura Walters, Dusanka Lalic, Robert A. Hegele, Alan T. Remaley, Daniel J. Rader, Richard L. Dunbar   +9 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

New mouse models for lipoprotein metabolism and atherosclerosis

, 2002
Cardiovascular Research Institute Maastricht, Department of Molecular Genetics, University of Maastricht, Maastricht, The Netherlands. Transgenic mouse models have been crucial to our current understanding of the mechanisms of lipoprotein metabolism ...
Hofker, M.H., de Winther, Menno P. J., Hofker, Marten H., de Winther, M.P.J.   +3 more
core   +1 more source