Results 11 to 20 of about 244,000 (301)

Antioxidants and lipoprotein metabolism [PDF]

Proceedings of the Nutrition Society, 1999
Lipoprotein metabolism plays a significant role in the pathogenesis of atherosclerosis and risk of vascular disease. Elevated levels of LDL and low levels of HDL are linked to the risk of cardiovascular disease. It is now widely accepted that oxidative modification of LDL affects the metabolism of lipoproteins, leading to their increased accumulation ...
M, Chopra, D I, Thurnham
openaire   +3 more sources

Impact of protein glycosylation on lipoprotein metabolism and atherosclerosis [PDF]

, 2021
Protein glycosylation is a post-translational modification consisting of the enzymatic attachment of carbohydrate chains to specific residues of the protein sequence.
Catapano, Alberico Luigi, Svecla, Monika, Catapano, Alberico L, Holleboom, Adriaan G, Holleboom, Adriaan G., Pirillo, Angela, Norata, Giuseppe D, Norata, Giuseppe Danilo   +7 more
core   +1 more source

Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen

Journal of Lipid Research, 2022
A significant proportion of patients with elevated LDL and a clinical presentation of familial hypercholesterolemia do not carry known genetic mutations associated with hypercholesterolemia, such as defects in the LDL receptor.
Diego Lucero, Ozan Dikilitas, Michael M. Mendelson, Zahra Aligabi, Promotto Islam, Edward B. Neufeld, Aruna T. Bansal, Lita A. Freeman, Boris Vaisman, Jingrong Tang, Christian A. Combs, Yuesheng Li, Szilard Voros, Iftikhar J. Kullo, Alan T. Remaley   +14 more
doaj   +1 more source

Apolipoprotein distribution in human lipoproteins separated by polyacrylamide gradient gel electrophoresis.

Journal of Lipid Research, 1988
The heterogeneity of serum lipoproteins (excluding very low density (VLDL) and intermediate density (IDL) lipoproteins) and that of lipoproteins secreted by HepG2 cells has been studied by immunoblot analysis of the apolipoprotein composition of the ...
C A Vézina, R W Milne, P K Weech, Y L Marcel   +3 more
doaj   +1 more source

Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism [PDF]

, 2008
Plasma lipoproteins are responsible for carrying triglycerides and cholesterol in the blood and ensuring their delivery to target organs. Regulation of lipoprotein metabolism takes place at numerous levels including via changes in gene transcription.
Kersten, A.H., Sander Kersten
core   +1 more source

Nonimmunochemical quantitation of mammalian apolipoprotein A-I in whole serum or plasma by nonreducing gel electrophoresis.

Journal of Lipid Research, 1989
A rapid and convenient method for the quantitation of mammalian apoA-I has been developed. The method involves nonreducing sodium dodecyl sulfate gel electrophoresis and Coomassie blue staining, and takes advantage of the relative abundance of apoA-I in ...
D S France, T E Hughes, R Miserendino, J A Spirito, J Babiak, J B Eskesen, C Tapparelli, J R Paterniti, Jr   +7 more
doaj   +1 more source

Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. [PDF]

, 2004
BACKGROUND: Some animal studies have suggested that conjugated linoleic acid (CLA) supplementation may have therapeutic potential with respect to insulin sensitivity and lipid metabolism, which are important cardiovascular disease (CVD) risk factors ...
Mullen, Anne, Anne Mullen, John J Nolan, Moloney, F, Yeow, Toh-Peng, Toh-Peng Yeow, Helen M Roche, Yeow, TP, Roche, HM, Fiona Moloney, Mullen, A, Nolen, JJ, Moloney, Fiona, Nolan, John J, Roche, Helen M   +14 more
core   +1 more source

An immunochemical marker of low density lipoprotein oxidation.

Journal of Lipid Research, 1989
Using monoclonal antibodies against apolipoprotein B (apoB) we studied changes in apoB immunoreactivity during copper ion-mediated oxidation of human low density lipoprotein (LDL).
Z Zawadzki, R W Milne, Y L Marcel
doaj   +1 more source

Protein polymorphism of a human plasma apolipoprotein D antigenic epitope.

Journal of Lipid Research, 1989
Based on our previous observation that monoclonal antibody anti-apoD-4E11 reacted with several HDL proteins we studied them further with three questions in mind: i) is there common protein polymorphism in healthy individuals?
R Camato, Y L Marcel, R W Milne, S Lussier-Cacan, P K Weech   +4 more
doaj   +1 more source

LCAT protects against Lipoprotein‐X formation in a murine model of drug‐induced intrahepatic cholestasis

Pharmacology Research & Perspectives, 2020
Familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is a rare genetic disease characterized by low HDL‐C levels, low plasma cholesterol esterification, and the formation of Lipoprotein‐X (Lp‐X), an abnormal cholesterol‐rich lipoprotein ...
Marcelo J. A. Amar, Lita A. Freeman, Takafumi Nishida, Maureen L. Sampson, Milton Pryor, Boris L. Vaisman, Edward B. Neufeld, Sotirios K. Karathanasis, Alan T. Remaley   +8 more
doaj   +1 more source