Results 151 to 160 of about 4,326 (177)

Angiopoietin-like protein 4(E40K) and ANGPTL4/8 complex have reduced, temperature-dependent LPL-inhibitory activity compared to ANGPTL4

Biochemical and Biophysical Research Communications, 2021
We previously demonstrated that angiopoietin-like 8 (ANGPTL8) forms a localized complex with ANGPTL4 to reduce its lipoprotein lipase (LPL)-inhibitory activity and enable increased postprandial uptake of fatty acids (FA) into adipose tissue. Because prolonged cold exposure may increase adipose tissue FA uptake and decrease circulating triglycerides (TG)
Yan Q Chen, Robert W Siegel, Mariam Ehsani   +2 more
exaly   +3 more sources

Silencing Angiopoietin‐Like Protein 4 (ANGPTL4) Protects Against Lipopolysaccharide‐Induced Acute Lung Injury Via Regulating SIRT1 /NF‐kB Pathway

Journal of Cellular Physiology, 2015
Lung inflammation and alveolar epithelial cell death are critical events in the development and progression of acute lung injury (ALI). Although angiopoietin‐like protein 4 (ANGPTL4) participates in inflammation, whether it plays important roles in ALI and alveolar epithelial cell inflammatory injury remains unclear.
Liang Guo, Fuyun Ji, Xueling Wu
exaly   +3 more sources

Plasma levels of angiopoietin-like protein 4 (ANGPTL4) are significantly lower preoperatively in colorectal cancer patients than in cancer-free patients and are further decreased during the first month after minimally invasive colorectal resection

Surgical Endoscopy and Other Interventional Techniques, 2012
Surgery has been associated with proangiogenic plasma protein changes that may promote tumor growth. Angiopoietin-like protein 4 (ANGPTL4) is expressed by endothelial cells and other tissues in response to hypoxia. Both intact ANGPTL4 and its partly degraded C-terminal fragment may promote tumor angiogenesis. This study had two purposes: to measure and
H M C Shantha Kumara, Xiaohong Yan, Richard L Whelan   +2 more
exaly   +3 more sources

Angiopoietin-like protein 4: health effects, modulating agents and structure–function relationships

Expert Review of Proteomics, 2012
The angiopoietin-like protein 4 (ANGPTL4/FIAF) has been identified as a multifunctional signal protein. It is produced by a variety of tissues, and secreted into the blood stream in glycosylated, oligomerized, native and cleaved isoforms, to modulate ...
Charlotte Grootaert, Tom Van de Wiele
exaly   +2 more sources

Angiopoietin-Like Proteins 4 ( ANGPTL4 ) Gene Polymorphisms and Risk of Brain Arteriovenous Malformation

Journal of Stroke and Cerebrovascular Diseases, 2018
Brain arteriovenous malformations (BAVMs) are formed by hypertrophied arterial vessels (afferents, feeders), a large number of arteriovenous shunts which become tangled to form a body (nidus) of malformation, which then expands draining proximal veins.
Sarafroz A. Erkinova, Ekaterina A. Sokolova, Kirill Y. Orlov, Vitaly S. Kiselev, Nikolay V. Strelnikov, Andrey V. Dubovoy, Elena N. Voronina, Maxim L. Filipenko   +7 more
openaire   +2 more sources

Increased Angiopoietin Like Proteins 4 (ANGPTL4) Is Associated with Higher Concentration of LDL-Triglycerides in Type 2 Diabetes

Diabetes, 2018
Background/Aims: Diabetic dyslipidemia is typically characterized by an increase in plasma triglycerides (TG), a concomitant increase in small dense (sd) low density lipoprotein (LDL) and atherogenic LDL-TG. Angiopoietin like protein 4 (ANGPTL4) is well established regulators of plasma TG level through regulating the activity of lipoprotein lipase ...
HIROE NAGAIKE, TOSHIYUKI HAYASHI, NORIKO NAKANISHI, MAKOTO OHARA, TAKESHI YAMAMOTO, TOMOYASU FUKUI, TSUTOMU HIRANO   +6 more
openaire   +1 more source

Role of Angiopoietin-like 4 (ANGPTL4), a Member of Matricellular Proteins: from Homeostasis to Inflammation and Cancer Metastasis

Current Angiogenesis, 2013
ANGPTL4 is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein consisting of a signal sequence, N-terminal coiled-coil and a fibrinogen like C-terminal domain.
Mintu Pal, Hari K. Koul
openaire   +1 more source

Angiopoietin‐like protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells

Acta Ophthalmologica, 2013
Abstract.Purpose:  Hyperglycaemia has been identified as major risk factor for diabetic retinopathy (DR). It is widely accepted that the progression of DR is mainly due to a local imbalance of pro‐ versus anti‐angiogenic factors in the retina. In this study, we investigated whether retinal pigment epithelial (RPE) cells produced pro‐angiogenic factors ...
Hirotaka, Yokouchi, Koki, Eto, Wataru, Nishimura, Norio, Takeda, Yasushi, Kaburagi, Shuichi, Yamamoto, Kazuki, Yasuda   +6 more
openaire   +2 more sources

Angiopoietin like protein 4 (ANGPTL4): a marker of alteration in lipid metabolism, insulin resistance and ectopic fat accumulation

2016
Alteration in lipid metabolism is a benchmark in the development of insulin resistance, type 2 diabetes and related cardiometabolic diseases. Angiopoietin like proteins (ANGPTL) are a family of secreted glycoproteins present in tissues (liver, heart, muscle, adipose tissue), macrophages and blood with pleiotropic effects on vascular cells, stem cell ...
Gastaldelli A, Gaggini M, Rosso C, Dellla Latta V, Marietti M, Caviglia G, Carli F, Buzzigoli E, Ciociaro D, Abate M, Smedile A, Saracco G, Bugianesi E   +12 more
openaire   +1 more source