Results 131 to 140 of about 456,743 (411)

Effect of amaranth proteins on the RAS system: In vitro, in vivo and ex vivo assays [PDF]

, 2020
The aim of this work was to analyse the hypotensive effect of amaranthprotein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo.
Aphalo, Paula, Añon, Maria Cristina, Quiroga, Alejandra Viviana, Rinaldi, Gustavo Juan, Suárez, Santiago   +4 more
core   +2 more sources

Frontiers in Nondrug Treatment of Sarcopenia: A Review of Pathological Mechanisms and the Latest Treatment Strategies

AGING MEDICINE, EarlyView.
This article mainly introduces the pathologic process of sarcopenia and the recent progress in diagnosis and treatment, especially the nondrug treatment. ABSTRACT Sarcopenia refers to the progressive decline and wasting of skeletal muscle function, typically linked to aging or as a secondary effect of various conditions, including systemic inflammation,
Qi‐Fei Kuang, Yu‐Qing Ni, You‐Shuo Liu   +2 more
wiley   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Alzheimer's Association clinical practice guideline for the Diagnostic Evaluation, Testing, Counseling, and Disclosure of Suspected Alzheimer's Disease and Related Disorders (DETeCD‐ADRD): Executive summary of recommendations for primary care

Alzheimer's &Dementia, EarlyView.
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old and aimed at specialists. This evidence‐based guideline was developed to empower all—including primary care—clinicians to implement a structured approach for evaluating a ...
Alireza Atri, Bradford C. Dickerson, Carolyn Clevenger, Jason Karlawish, David Knopman, Pei‐Jung Lin, Mary Norman, Chiadi Onyike, Mary Sano, Susan Scanland, Maria Carrillo   +10 more
wiley   +1 more source

Single-substrate Enzyme Kinetics: The Quasi-steady-state Approximation and Beyond [PDF]

J. Math. Chem. 51 (2013) 1467, 2012
We analyze the standard model of enzyme-catalyzed reactions at various substrate-enzyme ratios to identify the regions of validity of the quasi-steady-state approximation. Certain prevalent conditions are checked and compared against the actual findings. Efficacies of a few other measures are highlighted. Some very recent observations are rationalized,
arxiv  

Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent.

HYPERTENSION, 2019
The Ang II (Angiotensin II)-Angiotensin-(1-7) axis of the Renin Angiotensin System encompasses 3 enzymes that form Angiotensin-(1-7) [Ang-(1-7)] directly from Ang II: ACE2 (angiotensin-converting enzyme 2), PRCP (prolylcarboxypeptidase), and POP ...
P. Serfozo, J. Wysocki, Gvantca Gulua, Arndt Schulze, M. Ye, Pan Liu, Jing Jin, M. Bader, M. Bader, T. Myöhänen, J. Garcia-horsman, D. Batlle   +11 more
semanticscholar   +1 more source

ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice [PDF]

, 2019
OBJECTIVES: The present study aimed to investigate cardiovascular autonomic modulation and angiotensin II (Ang II) activity in diabetic mice that were genetically engineered to harbor two or three copies of the angiotensin-converting enzyme gene. METHODS:
Dartora, Daniela Ravizzoni, De Angelis, Kátia, Evangelista, Fabiana de Sant’Anna, Fiorino, Patricia, Flues, Karin, Irigoyen, Maria Claúdia, Moraes, Oscar Albuquerque de, Mostarda, Cristiano, Rodrigues, Bruno, Scapini, Kátia Bilhar   +9 more
core   +1 more source

Respiratory virus mRNA vaccines: mRNA Design, clinical studies, and future challenges

Animal Models and Experimental Medicine, EarlyView.
Abstract Respiratory infectious diseases frequently erupt on a global scale, with RNA viruses, such as SARS‐CoV‐2, RSV, and influenza viruses, posing challenges to vaccine development due to their high mutation rates. Traditional vaccine development cycles are lengthy and struggle to keep pace with rapidly evolving viruses, whereas messenger RNA (mRNA)
Linlin Zheng, Han Feng
wiley   +1 more source

Effective inter-symbol interference mitigation with a limited amount of enzymes in molecular communications [PDF]

arXiv, 2016
In molecular communication via diffusion (MCvD), the inter-symbol interference (ISI) is a well known severe problem that deteriorates both data rates and link reliability. ISI mainly occurs due to the slow and highly random propagation of the messenger molecules, which causes the emitted molecules from the previous symbols to interfere with molecules ...
arxiv  

Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study

British medical journal, 2018
Objective To determine whether the use of angiotensin converting enzyme inhibitors (ACEIs), compared with use of angiotensin receptor blockers, is associated with an increased risk of lung cancer. Design Population based cohort study.
Blánaid M. Hicks, K. Filion, H. Yin, L. Sakr, J. Udell, L. Azoulay   +5 more
semanticscholar   +1 more source