Results 361 to 370 of about 462,118 (388)
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Glucocorticoid induction of angiotensin converting enzyme
Agents and Actions, 1986Angiotensin converting enzyme (ACE) converts angiotensin I (Angio I) to angiotensin II (Angio II) and inactivates bradykinin (BK). Glucocorticoids in the physiological range increase ACE in rabbit alveolar macrophages and bovine endothelial cells in culture.
IALENTI, ARMANDO +3 more
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Angiotensin-Converting Enzyme Inhibitors
AACN Advanced Critical Care, 1992The angiotensin-converting enzyme (ACE) inhibitors available today include Captopril (Capoten), enalapril (Vasotec), enaloprilat (Vasotec IV), lisinopril (Prinivil, Zestril), benazepril (Lotensin), fosinopril (Monopril), and ramipril (Atace). These drugs are used in the treatment of hypertension and congestive heart failure.
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Renin and angiotensin converting enzyme in elasmobranchs
General and Comparative Endocrinology, 1992Renin-like activity (RLA) and angiotensin I converting enzyme-like activity (ACELA), the two key enzymes of the renin-angiotensin system (RAS), were sought in the elasmobranch Scyliorhinus canicula. Renal extracts were desalted in a G-25 and eluted in a G-100 Sephadex column (calibration 15,000-70,000).
L.B. O'Toole +15 more
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Angiotensin-converting enzyme inhibitors
2001Publisher Summary Angiotensin-converting enzyme (ACE) inhibitors were first studied clinically in the 1970s. ACE inhibitors were discovered by taking advantage of previous basic research on the physiology of sodium, potassium, and water homeostasis and blood pressure regulation, in a reciprocal way ACE have also advanced research in this field, and ...
Arthur A. Patchett, Joël Ménard
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Clinical and Experimental Pharmacology and Physiology, 1992
SUMMARY1. The effects of angiotensin‐converting enzyme (ACE) inhibitors on the tissue ACE were assessed by quantitative in vitro autoradiography after acute and chronic administrations of the drugs.2. Following acute administration of lisinopril, perindopril or benazepril, ACE was markedly inhibited in the lung, kidney and blood vessels but not in the ...
Rose Perich +4 more
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SUMMARY1. The effects of angiotensin‐converting enzyme (ACE) inhibitors on the tissue ACE were assessed by quantitative in vitro autoradiography after acute and chronic administrations of the drugs.2. Following acute administration of lisinopril, perindopril or benazepril, ACE was markedly inhibited in the lung, kidney and blood vessels but not in the ...
Rose Perich +4 more
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Angiotensin Converting Enzyme (ACE), is a zinc containing metallopeptidase, best known for its role in the conversion of Ang I in the active peptide Ang II, which plays a pivotal role in the blood pressure (BP) regulation trough the Renin Angiotensin System (RAS). In the last decades RAS has been deeply studied in all its aspects and implications.
Arrighi, F., Berrino, E., Secci, D.
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Arrighi, F., Berrino, E., Secci, D.
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Angiotensin‐Converting Enzyme in Sarcoidosis
Acta Medica Scandinavica, 1979ABSTRACT Using a spectrophotometric assay with l‐hippuryl‐l‐histidyl‐l‐leucine as substrate, s‐angio‐tensin‐converting enzyme (SACE) was determined in 85 sarcoidosis patients, 116 healthy controls and 150 patients with various non‐sarcoid diseases. The controls showed no sex or age variation and had SACE levels of 24.4±6.2 U/ml (mean ± 1 S.D.), giving ...
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Angiotensin-Converting Enzyme Inhibitors
Medical Clinics of North America, 1987In summary, ACE inhibitors are effective in reducing blood pressure as initial therapy in some hypertensive patients and in combination with diuretics and other agents in virtually all hypertensives. ACE inhibitors are uniquely advantageous because of their favorable hemodynamic effects, the lack of adverse metabolic effects, and their ability to ...
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Assay of Tissue Angiotensin Converting Enzyme
Journal of Cardiovascular Pharmacology, 1989The distinction between a circulating renin-angiotensin system and a tissue renin-angiotensin system led us to determine tissue angiotensin converting enzyme (ACE) activity. This study establishes the experimental conditions for a good reproducibility of the fluorimetric assay of ACE and describes the use of [3H]ramiprilat to characterize ACE ...
Jean-Louis Imbs +6 more
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2 Inhibitiors of Angiotensin-Converting Enzyme
1980Publisher Summary This chapter focuses on the development, mechanism of action, and biological activity of two distinct classes of therapeutically useful inhibitors of angiotensin-converting enzyme: the snake venom peptides and a newly developed class of orally active inhibitors that were designed for specific binding to the active site of this ...
David W. Cushman, Miguel A. Ondetti
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