Results 71 to 80 of about 318,155 (304)
Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]
, 2009 Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Allen, James M. +12 more
core +1 more source
Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases
Animal Models and Experimental Medicine, EarlyView.Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam +4 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2015 Background: Angiotensin converting enzyme (ACE) is secreted from vascular endothelium. This enzyme is one of the main determinants of blood pressure regulation.
Maryam Mirhaj +3 more
doaj
Angiotensin-converting enzyme and male fertility [PDF]
Proceedings of the National Academy of Sciences, 1998 The angiotensin-converting enzyme (ACE; EC3.4.15.1) gene (Ace) encodes both a somatic isozyme found in blood and several other tissues, including the epididymis, and a testis-specific isozyme (testis ACE) found only in developing spermatids and mature sperm.
J R, Hagaman +8 more
openaire +2 more sources
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
core +1 more source
Porcine kidney xenotransplantation: From primate models to clinical reality
Animal Models and Experimental Medicine, EarlyView.In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
Journal of Tropical Pharmacy and Chemistry, 2016 Penelitian ini bertujuan untuk mengetahui tingkat hidrolisis tanduk muda rusa Sambar (Rusa unicolor) dengan enzim pencernaanm yaitu enzim pepsin dan tripsin, serta mengetahui adanya aktivitas Angiotensin I-Converting Enzyme Inhibitor ...
Arif Ismanto
doaj +1 more source
, 2021 Angiotensin converting enzyme (ACE) is well known for its dual actions to convert inactive Ang I to active Ang II, and degrades active bradykinin (BK), which plays an important role in controlling blood pressure. Because it is the bottleneck step for the production of pressor Ang II, it was targeted pharmacologically in the 1970s.
openaire +1 more source
Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis
Arthritis &Rheumatology, EarlyView.Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm +2 more
wiley +1 more source
Relationship between antihypertensive medications and cognitive impairment: Part II. Review of Physiology and animal studies [PDF]
, 2016 Purpose of Review There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHM) and dementia risk are
Carlson, MC +4 more
core +1 more source