Results 291 to 300 of about 362,216 (339)
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Conversion of angiotensin I to angiotensin II
The American Journal of Medicine, 1976The angiotensin I converting enzyme has two important functions: it inactivates bradykinin and converts angiotensin I to angiotensin II. Inhibition of the enzyme blocks the renin-angiotensin system and decreases systemic blood pressure if the pressure is maintained or increased by renin. The enzyme occurs in a variety of tissues and cell forms.
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Radioimmunoassay of Angiotensin
Nature, 1968HABER et al.1 showed that antibodies elicited in rabbits by copolymers of angiotensin with poly-L-lysine can be used for radioimmunoassay of angiotensin. The following are details and some results of the method we have developed. Comparing the binding affinity of three different rabbit antisera to Val5-angiotensin II amide (‘Hypertensin’, Ciba) and ...
J.M. Van Der Meer +2 more
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Regulatory Peptides, 1999
The object of this review is to describe the role of the renin-angiotensin system in control of aldosterone secretion. The review focuses on the roles of the circulating renin-angiotensin (RAS) system, the activity of which is determined predominantly by control of renin secretion from the kidney and on the role of the intra-adrenal RAS.
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The object of this review is to describe the role of the renin-angiotensin system in control of aldosterone secretion. The review focuses on the roles of the circulating renin-angiotensin (RAS) system, the activity of which is determined predominantly by control of renin secretion from the kidney and on the role of the intra-adrenal RAS.
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The Angiotensin II Receptor and the Actions of Angiotensin II
Journal of Cardiovascular Pharmacology, 1990Angiotensin II (Ang II) is a potent effector peptide of the renin-angiotensin system that exerts a wide variety of physiological actions on the cardiovascular, renal, endocrine, and central and peripheral nervous systems. Angiotensin exerts its actions by binding to specific receptors in the plasma membrane of various tissues.
David E. Dostal, Michael J. Peach
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Angiotensin-(1–7) and the renin–angiotensin system
Current Opinion in Nephrology and Hypertension, 2007In this review we will focus on the recent findings related to angiotensin-(1-7) as an angiotensin II counter-regulatory peptide within the renin-angiotensin system.The identification of the angiotensin-converting enzyme homologue ACE2 as an angiotensin peptide processing enzyme and of Mas as a receptor for angiotensin-(1-7) has contributed to ...
Anderson J. Ferreira, Robson A.S. Santos
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Angiotensin and angiotensin-converting enzyme inhibitors
Baillière's Clinical Anaesthesiology, 1994Summary The advent of the increasing use of different angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension and cardiac failure has resulted in intense interest in the renin-angiotensin system (RAS) and its manipulation for therapeutic gain, and thus more patients will present for surgical anaesthesia while on maintenance ...
Berend Mets, Edward D. Miller
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CONVERSION OF ANGIOTENSIN I TO ANGIOTENSIN II IN SHEEP
Clinical and Experimental Pharmacology and Physiology, 1978SUMMARY1. The methodology for measurement of angiotensin I in whole blood is described.2. Angiotensin I was measured in arterial and venous blood samples from sodium‐loaded, sodium‐replete and sodium‐depleted sheep. Venous blood concentrations were higher than arterial angiotensin I concentrations.
John P. Coghlan +5 more
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Angiotensin (1-7) and other Angiotensin Peptides
Current Pharmaceutical Design, 2013In the classical renin angiotensin system (RAS), angiotensin II Ang IIplays many important roles in cardiovascular disease and in kidney, brain, and other organs via the Ang II type 1 receptor (AT1). The RAS consists of many angiotensin peptides, including Ang (1-7), Ang (1-9), Ang (2-8), and Ang IV. Ang (1-7), produced by angiotensin-converting enzyme
Mitsuru Ohishi +2 more
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Angiotensin-Converting Enzyme Inhibition, Angiotensin, and Cognition
Journal of Cardiovascular Pharmacology, 1992In these studies, we have investigated possible cognition-enhancing effects of angiotensin-converting enzyme (ACE) inhibition, and putative neurochemical correlates for these actions. In a mouse habituation model, ACE inhibitors improved basal performance and antagonized scopolamine-induced deficits.
Nicholas M. Barnes +7 more
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JAMA: The Journal of the American Medical Association, 1980
To the Editor.— I think the time has come when the cliche, "the mechanisms and cause of essential hypertension are unknown," can justifiably be altered to "it is highly probable that the core of the mechanism of essential, renovascular, and malignant hypertension is angiotensin." The evidence from blocking the converting enzyme and from peptide ...
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To the Editor.— I think the time has come when the cliche, "the mechanisms and cause of essential hypertension are unknown," can justifiably be altered to "it is highly probable that the core of the mechanism of essential, renovascular, and malignant hypertension is angiotensin." The evidence from blocking the converting enzyme and from peptide ...
openaire +3 more sources