Results 271 to 280 of about 349,498 (354)

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao, Sinan Ai, Yaoxian Wang, Yuning Liu, Jingwei Zhou, Qingqing Liu, Xu Wang, Danting Li, Xin Li, Lin Wang, Jinyi Hou, Liang Peng, Zhen Wang   +12 more
wiley   +1 more source

Comparative Effectiveness of Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin Receptor Blockers: Multidatabase Target Trial Emulation Studies. [PDF]

Hypertension
Xie C, Chen R, Zhou S, Lin Y, Liu J, Su L, Pang M, Guo Z, Luo F, Chen L, Kong Y, Nie S.   +11 more
europepmc   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Angiotensin receptor blocker and angiotensin-converting enzyme inhibitor use and survival in gastric cancer patients: a Finnish nationwide cohort study. [PDF]

Gastric Cancer
Auvinen A, Aaltonen P, Mustonen H, Haglund C, Puolakkainen P, Seppänen H.   +5 more
europepmc   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

PREDIKSI TOKSISITAS, ANALISIS ADME DAN DOCKING MOLEKULER ASIATICOSIDE TERHADAP PENGHAMBATAN ANGIOTENSIN CONVERTING ENZYME

Rafiastiana Capritasari, Akrom Akrom, Arif Budi Setianto, Megananda Hiranya Putri, Elly Rosita Hasna, Febriana Astuti   +5 more
openalex   +2 more sources

Progression of albumin/creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) over 24 years in people with type 2 diabetes. Drivers, potential protectors and associated mortality

Diabetic Medicine, EarlyView.
Abstract Introduction The pathophysiology of chronic kidney disease (CKD) and type 2 diabetes (T2D) is multifactorial and associated with a plethora of underlying conditions and complications. Their link is reciprocal and understanding its nature, particularly over time, could improve the health of many.
Andreas Matheou, Orestis Zavlis, Steve White, Thomas McDonnell, Alexander Warner‐Levy, John Warner‐Levy, Loren Wilkins, Hellena Habte‐Asres, Abigail Lay, Liliana Shalamanova, Martin Whyte, Martin Gibson, Philip A. Kalra, Adrian Heald   +13 more
wiley   +1 more source

Angiotensin-Converting Enzyme Inhibitor (ACEI)-Induced Angioedema After Re-exposure to Lisinopril: A Case Report and Clinical Review. [PDF]

Cureus
Tou LC, DeMott JD, Palacios JM.
europepmc   +1 more source

Reviewer #2 (Public review): Dimerization and dynamics of human angiotensin-I converting enzyme revealed by cryo-EM and MD simulations

openalex   +1 more source

Work productivity, associated risk factors and costs on presenteeism and absenteeism in Chinese patients with young‐onset type‐2 diabetes in Hong Kong

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Those with young‐onset type‐2 diabetes (YOD), diagnosed before age of 40 years, experience heightened risk of complications. The economic burden extends beyond medical costs, impacting work productivity. Materials and Methods Chinese patients with YOD were recruited between June 2023 and April 2024 in the Precision Medicine to redefine ...
Juliana N. M. Lui, Kelly T. C. Wong, Eric S. H. Lau, Sunny C. S. Chan, Nga Sze Wong, Jenny Y. Z. Zhang, Kit Ming Wai, Chun Kwan O, Baoqi Fan, Hongjiang Wu, Ronald C. W. Ma, Alice P. S. Kong, Andrea O. Y. Luk, Elaine Y. K. Chow, Juliana C. N. Chan   +14 more
wiley   +1 more source