Results 41 to 50 of about 349,498 (354)

Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

Cellular & Molecular Immunology, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel corona virus disease (COVID-19). To date, no prophylactic vaccines or approved therapeutic agents are available for preventing and treating this highly
Xiangyu Chen, Ren Li, Zhiwei Pan, C. Qian, Yang Yang, Renrong You, J. Zhao, Pinghuang Liu, Leiqiong Gao, Zhirong Li, Qizhao Huang, Lifan Xu, Jianfang Tang, Qin Tian, W. Yao, Li Hu, Xiaofeng Yan, Xinyuan Zhou, Yuzhang Wu, K. Deng, Zheng Zhang, Zhaohui Qian, Yaokai Chen, L. Ye   +23 more
semanticscholar   +1 more source

Next Step in Chronic Kidney Disease Therapy

Počki, 2016
Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers are the basis of renoprotection therapy in chronic kidney disease. Parallel to decrease of glomerular filtration rate, there is an increase in the activity of the sympathetic nervous ...
D.D. Ivanov
doaj   +1 more source

Could Anti‐Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID‐19 Infection? Data From Centers of Southern Italy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
BACKGROUND Coronavirus disease 2019 (COVID‐19) is the cause of a pandemic disease, with severe acute respiratory syndrome by binding target epithelial lung cells through angiotensin‐converting enzyme 2 in humans.
Celestino Sardu, Paolo Maggi, Vincenzo Messina, Pasquale Iuliano, Antonio Sardu, Vincenzo Iovinella, Giuseppe Paolisso, Raffaele Marfella   +7 more
doaj   +1 more source

A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

Journal of Biomolecular Structure and Dynamics, 2020
The widespread antigenic changes lead to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically different from the previous circulating species.
A. Hasan, B. A. Paray, A. Hussain, F. Qadir, F. Attar, F. M. Aziz, M. Sharifi, H. Derakhshankhah, B. Rasti, Masoumeh Mehrabi, Koorosh Shahpasand, A. Saboury, M. Falahati   +12 more
semanticscholar   +1 more source

Pathological Role of Angiotensin II in Severe COVID-19

TH Open, 2020
The activated renin–angiotensin system induces a prothrombotic state resulting from the imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector molecule of the activated renin–angiotensin system and is degraded by the ...
Wolfgang Miesbach
doaj   +1 more source

Angiotensin-converting enzyme gene 2350 G/A polymorphism and susceptibility to atrial fibrillation in Han Chinese patients with essential hypertension

Clinics, 2013
OBJECTIVE: The angiotensin-converting enzyme gene is one of the most studied candidate genes related to atrial fibrillation. Among the polymorphisms of the angiotensin-converting enzyme gene, the 2350 G/A polymorphism (rs4343) is known to have the most ...
Min-Hui Jiang, Ya-Min Su, Jian-Zhong Tang, Yan-Bo Shen, Xin-Tao Deng, Ding-Shan Yuan, Jie Wu, Min Pan, Zhong-Wei Huang   +8 more
doaj   +1 more source

Postoperative angioedema induced by angiotensin-converting enzyme inhibitor: case report [PDF]

Revista Brasileira de Anestesiologia, 2019
Background and objectives: Angioedema is a potentially fatal condition that may occur at any time in the perioperative period. It may result from histamine release, hypersensitivity reaction to drugs, or be triggered by bradykinin, in non-allergic ...
Flora Margarida Barra Bisinotto, Beatrice Cavalcanti Seabra, Fernando B. Prata Lóes, Laura Bisinotto Martins, Luciano Alves Matias da Silveira   +4 more
doaj   +3 more sources

Angiotensin-Converting Enzyme 2

Definitions, 2020
Angiotensin-converting enzyme 2 (805 aa, ~92 kDa) is encoded by the human ACE2 gene. This protein plays a role in both vasodilation and protein cleavage.

semanticscholar   +1 more source

Aktivitas Antioksidan Danangiotensin-I Converting Enzyme Inhibitor oleh Yogurt dengan Ekstrak Daun Ficus glomerata Roxb

Agritech, 2018
Ficus glomerata Roxb has been known to have flavonoids. Flavonoids in plant are known for their antioxidant activity and ability to the Angiotensin Converting Enzyme I- inhibitor.
Baiq Rani Dewi Wulandani, Endang Sutriswati Rahayu, Yustinus Marsono, Tyas Utami   +3 more
doaj   +1 more source

Angiotensin‐converting enzyme inhibitors and angiotensin II receptor blockers are not associated with severe COVID‐19 infection in a multi‐site UK acute hospital trust

European Journal of Heart Failure, 2020
The SARS‐CoV‐2 virus binds to the angiotensin‐converting enzyme 2 (ACE2) receptor for cell entry. It has been suggested that angiotensin‐converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB), which are commonly used in patients ...
D. Bean, Zeljko Kraljevic, Thomas Searle, R. Bendayan, O'Gallagher Kevin, A. Pickles, A. Folarin, Lukasz Roguski, Kawsar Noor, Anthony Shek, R. Zakeri, A. Shah, J. Teo, R. Dobson   +13 more
semanticscholar   +1 more source