Results 41 to 50 of about 466,155 (352)

Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

Cellular & Molecular Immunology, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel corona virus disease (COVID-19). To date, no prophylactic vaccines or approved therapeutic agents are available for preventing and treating this highly
Xiangyu Chen, Ren Li, Zhiwei Pan, C. Qian, Yang Yang, Renrong You, J. Zhao, Pinghuang Liu, Leiqiong Gao, Zhirong Li, Qizhao Huang, Lifan Xu, Jianfang Tang, Qin Tian, W. Yao, Li Hu, Xiaofeng Yan, Xinyuan Zhou, Yuzhang Wu, K. Deng, Zheng Zhang, Zhaohui Qian, Yaokai Chen, L. Ye   +23 more
semanticscholar   +1 more source

Significant correlation of angiotensin converting enzyme and glycoprotein IIIa genes polymorphisms with unexplained recurrent pregnancy loss in north of Iran [PDF]

, 2016
Background: Spontaneous abortion is considered as the most complex problem during pregnancy. Thrombophilia is resumed as a cause of recurrent pregnancy loss (RPL). Glycoprotein IIIa (GPIIIa) gene is involved in thrombosis and abortion.
Farazmandfar, T., Fazelnia, S., Hashemi-Soteh, S.M.B.   +2 more
core   +1 more source

Angiotensin converting enzyme 1 in the median preoptic nucleus contributes to chronic intermittent hypoxia hypertension

Physiological Reports, 2017
Obstructive sleep apnea is associated with hypertension and cardiovascular disease. Chronic intermittent hypoxia is used to model the arterial hypoxemia seen in sleep apnea patients and is associated with increased sympathetic nerve activity and a ...
Katelynn E. Faulk, T. Prashant Nedungadi, J. Thomas Cunningham   +2 more
doaj   +1 more source

ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice

Clinics, 2018
OBJECTIVES: The present study aimed to investigate cardiovascular autonomic modulation and angiotensin II (Ang II) activity in diabetic mice that were genetically engineered to harbor two or three copies of the angiotensin-converting enzyme gene ...
Oscar Albuquerque de Moraes, Karin Flues, Kátia Bilhar Scapini, Cristiano Mostarda, Fabiana de Sant’Anna Evangelista, Bruno Rodrigues, Daniela Ravizzoni Dartora, Patricia Fiorino, Kátia De Angelis, Maria Cláudia Irigoyen   +9 more
doaj   +1 more source

Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera

Hematology, 2023
Objective: Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. First-line therapies are directed at lowering hematocrit levels. After the discovery of a mutation in the Janus kinase 2 (JAK2V617F)
Angela Bozza, Martina Bernardi, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Giuseppe Astori   +5 more
doaj   +1 more source

Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality.

Journal of the American Medical Association (JAMA), 2020
Importance It has been hypothesized that angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) may make patients more susceptible to coronavirus disease 2019 (COVID-19) and to worse outcomes through upregulation of the ...
E. Fosbøl, J. Butt, Lauge Østergaard, C. Andersson, C. Selmer, K. Kragholm, M. Schou, M. Phelps, G. Gislason, T. Gerds, C. Torp‐Pedersen, L. Køber   +11 more
semanticscholar   +1 more source

Comparative effectiveness of enalapril, lisinopril, and ramipril in the treatment of patients with chronic heart failure: a propensity score-matched cohort study [PDF]

, 2017
Background: Angiotensin converting enzyme inhibitors (ACEIs) are recommended as first-line therapy in patients with heart failure with reduced ejection fraction (HFrEF). The comparative effectiveness of different ACEIs is not known. Methods and results:
Agewall, Stefan, Atar, Dan, Clark, Andrew L., Cleland, John G.F., Corletto, Anna, Frankenstein, Lutz, Fröhlich, Hanna, Goode, Kevin, Grundtvig, Morten, Henning, Felix, Hole, Torstein, Katus, Hugo A., Kazmi, Syed, Schellberg, Dieter, Täger, Tobias   +14 more
core   +1 more source

A continuous fluorescent assay for the determination of plasma and tissue angiotensin I-converting enzyme activity

Brazilian Journal of Medical and Biological Research, 2005
A continuous assay using internally quenched fluorescent peptides with the general sequence Abz-peptidyl-(Dnp)P-OH (Abz = ortho-aminobenzoic acid; Dnp = 2,4-dinitrophenyl) was optimized for the measurement of angiotensin I-converting enzyme (ACE) in ...
M.F. Alves, M.C. Araujo, M.A. Juliano, E.M. Oliveira, J.E. Krieger, D.E. Casarini, L. Juliano, A.K. Carmona   +7 more
doaj   +1 more source

Association of Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers With Testing Positive for Coronavirus Disease 2019 (COVID-19).

JAMA cardiology, 2020
Importance The role of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) in the setting of the coronavirus disease 2019 (COVID-19) pandemic is hotly debated.
N. Mehta, A. Kalra, A. Nowacki, Scott Anjewierden, Zheyi Han, Pavan Bhat, A. Carmona-Rubio, M. Jacob, G. Procop, S. Harrington, A. Milinovich, L. Svensson, L. Jehi, James B. Young, M. Chung   +14 more
semanticscholar   +1 more source

Pharmacological effects of raas blockade in ischemic nephropathy [PDF]

, 2016
Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio, Cianci, Rosario, Coppolino, Giuseppe, Di Mario, Francesca, Farrah, Tariq E., Fuiano, Giorgio, Gigante, Antonietta, Rivoli, Laura, Rosato, Edoardo   +8 more
core   +1 more source