Results 51 to 60 of about 25,584,253 (297)

Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2 [PDF]

, 2009
Angiotensin-converting enzyme (ACE) 2 is a recently identified homologue of ACE. There is great interest in the therapeutic benefit for ACE2 overexpression in the heart.
Smith, Godfrey, McBride, Martin, Graham, Delyth, Nicklin, Stuart A., Masson, Rachel, Craig, Margaret Anne, Gregorevic, Paul, Napoli, Claudio, Dominiczak, Anna F., Allen, James M., Baker, Andrew H., Gilday, Kirsten, Chamberlain, Jeffrey S.   +12 more
core   +1 more source

Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients

eLife, 2020
The discovery of angiotensin converting enzyme-2 (ACE-2) as the receptor for SARS- CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) has implicated the renin-angiotensin-aldosterone system in acute respiratory distress syndrome (ARDS) and ...
Gian Paolo Rossi, Viola Sanga, Matthias Barton   +2 more
doaj   +1 more source

Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review

Environmental Chemistry Letters, 2020
Many major cities that witnessed heavy air pollution by nitrogen dioxide (NO 2 ) and particulate matter (PM) have experienced a high rate of infection and severity of the coronavirus disease pandemic (COVID-19).
B. Paital, P. Agrawal
semanticscholar   +1 more source

Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer’s Disease

International Journal of Molecular Sciences, 2021
Alzheimer’s disease is a chronic neurodegenerative disorder and represents the main cause of dementia globally. Currently, the world is suffering from the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome ...
Q. Ding, N. Shults, Sergiy G. Gychka, B. T. Harris, Y. Suzuki   +4 more
semanticscholar   +1 more source

Angiotensin-converting enzyme insertion/deletion polymorphism does not influence the restenosis rate after coronary stent implantation [PDF]

, 2002
Background. Experimental studies have shown an activation of the angiotensin-converting enzyme (ACE) system as a response to endothelial injury. Recent publications have elucidated the hypothesis that the ACE gene polymorphism may influence the level of ...
Hausmann, Dirk, Koschyk, Dietmar H., Grip, Lars, Ferrari, Markus, de Jaegere, Peter, Rieber, Johannes, Figulla, Hans R., Mudra, Harald, Schächinger, Volker, Rothman, Martin, Voudris, Vassilis   +10 more
core   +1 more source

Could Anti‐Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID‐19 Infection? Data From Centers of Southern Italy

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
BACKGROUND Coronavirus disease 2019 (COVID‐19) is the cause of a pandemic disease, with severe acute respiratory syndrome by binding target epithelial lung cells through angiotensin‐converting enzyme 2 in humans.
Celestino Sardu, Paolo Maggi, Vincenzo Messina, Pasquale Iuliano, Antonio Sardu, Vincenzo Iovinella, Giuseppe Paolisso, Raffaele Marfella   +7 more
doaj   +1 more source

Impact of Thiol–Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin-Converting Enzyme 2 Receptor

bioRxiv, 2020
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to an ongoing pandemic of coronavirus disease (COVID-19), which started in 2019.
S. Hati, S. Bhattacharyya
semanticscholar   +1 more source

Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation

Peptides, 2022
Angiotensin-converting enzyme-2, or ACE2, is primarily a zinc-dependent peptidase and ectoenzyme expressed in numerous cell types and functioning as a counterbalance to ACE in the renin-angiotensin system.
A. Turner, N. Nalivaeva
semanticscholar   +1 more source

Soluble angiotensin-converting enzyme 2 association with lipid metabolism

Frontiers in Medicine, 2022
Increased expression of angiotensin-converting enzyme 2 (ACE2) is one of the likely explanations for disease severity in patients with coronavirus disease 2019 (COVID-19). In this study, we aimed to test whether soluble ACE2 (sACE2) levels are correlated
Izumi Nagatomo, Kaori Nakanishi, Ryohei Yamamoto, Seiko Ide, Chisaki Ishibashi, Toshiki Moriyama, Keiko Yamauchi-Takihara   +6 more
doaj   +1 more source

A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

Journal of Biomolecular Structure and Dynamics, 2020
The widespread antigenic changes lead to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory syndrome (SARS)-CoV-2 that is immunologically different from the previous circulating species.
Anwarul Hasan, B. A. Paray, A. Hussain, F. Qadir, F. Attar, F. M. Aziz, M. Sharifi, H. Derakhshankhah, B. Rasti, Masoumeh Mehrabi, Koorosh Shahpasand, A. Saboury, M. Falahati   +12 more
semanticscholar   +1 more source