Results 31 to 40 of about 25,584,253 (297)

Stimulation of Angiotensin Converting Enzyme 2: A Novel Treatment Strategy for Diabetic Nephropathy

Frontiers in Physiology, 2022
Despite current therapies for diabetic nephropathy, many patients continue to progress to end-stage renal disease requiring renal replacement therapy.
Haru Nomura, Sanjaya Kuruppu, Niwanthi W. Rajapakse   +2 more
doaj   +1 more source

Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice

Nature Communications, 2020
Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) by the human cytokeratin 18 ...
Fatai S. Oladunni, Jun-Gyu Park, P. Pino, O. Gonzalez, A. Akhter, Anna Allué-Guardia, Angélica M. Olmo-Fontánez, S. Gautam, Andreu Garcia-Vilanova, C. Ye, Kevin Chiem, Colwyn A. Headley, Varun Dwivedi, Laura M. Parodi, Kendra J. Alfson, Hilary M Staples, A. Schami, J. García, Alison Whigham, R. Platt, Michal Gazi, Jesse C. Martinez, Colin Chuba, S. Earley, Oscar H Rodriguez, S. Mdaki, Katrina N. Kavelish, Renee Escalona, C. Hallam, Corbett Christie, J. Patterson, T. Anderson, R. Carrion, E. Dick, Shannan Hall-Ursone, L. Schlesinger, X. Alvarez, D. Kaushal, L. Giavedoni, J. Turner, L. Martínez-Sobrido, J. Torrelles   +41 more
semanticscholar   +1 more source

Thymosin-α1 binds with ACE and downregulates the expression of ACE2 in human respiratory epithelia

Frontiers in Bioscience-Landmark, 2022
Background: Thymosin-α1 has been implicated into the treatment of novel respiratory virus Coronavirus Disease 2019 (COVID-19), but the underlying mechanisms are still disputable.
Yu-Hang Zhang, Wen-Yu Wang, Xiao-Cong Pang, Zhi Wang, Cheng-Zhuo Wang, Hang Zhou, Bo Zheng, Yi-Min Cui   +7 more
doaj   +1 more source

Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor

Cellular & Molecular Immunology, 2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic of novel corona virus disease (COVID-19). To date, no prophylactic vaccines or approved therapeutic agents are available for preventing and treating this highly
Xiangyu Chen, Ren Li, Z. Pan, C. Qian, Yang Yang, Renrong You, Jing Zhao, Ping-Huang Liu, Lei-Qiong Gao, Zhirong Li, Qi-Zhao Huang, Li-Fan Xu, Jianfang Tang, Qin Tian, W. Yao, Li Hu, Xiaofeng Yan, Xinyuan Zhou, Yu-Zhang Wu, K. Deng, Zheng Zhang, Zhaohui Qian, Yao-Kai Chen, L. Ye   +23 more
semanticscholar   +1 more source

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure [PDF]

, 2008
Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear.
Julian Thompson, Nicholas S Hopkinson, Anthony Kehoe, Hopkinson, NS, Humphries, SE, Mostafa Ghanei, Montgomery Hugh, Khoshbaten, A, Hopkinson Nicholas S, Soroush, MR, Hugh Montgomery, Thompson Julian, Hosseini-Khalili, AR, Steve E Humphries, Kehoe, A, Montgomery, H, Ghanei, M, Kehoe Anthony, Hosseini-khalili Ali, Khoshbaten A, A Khoshbaten, Mohammad Reza Soroush, Soroush Mohammad, Thompson, J, Humphries Steve E, Ghanei Mostafa, Ali Reza Hosseini-khalili   +26 more
core   +2 more sources

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

European Heart Journal, 2020
Aims The current pandemic coronavirus SARS-CoV-2 infects a wide age group but predominantly elderly individuals, especially men and those with cardiovascular disease. Recent reports suggest an association with use of renin–angiotensin–aldosterone system (
I. Sama, A. Ravera, B. Santema, H. van Goor, J. T. ter Maaten, J. Cleland, M. Rienstra, A. Friedrich, N. Samani, L. Ng, K. Dickstein, C. Lang, G. Filippatos, S. Anker, P. Ponikowski, M. Metra, D. van Veldhuisen, A. Voors   +17 more
semanticscholar   +1 more source

Angiotensin-Converting Enzyme 2: The First Decade

International Journal of Hypertension, 2012
The renin-angiotensin system (RAS) is a critical regulator of hypertension, primarily through the actions of the vasoactive peptide Ang II, which is generated by the action of ...
Nicola E. Clarke, Anthony J. Turner
doaj   +1 more source

Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective

Molecular Biology Reports, 2022
Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused millions of infections and deaths worldwide since its discovery in late 2019 in Wuhan, China.
Subhomoi Borkotoky, D. Dey, Zaved Hazarika   +2 more
semanticscholar   +1 more source

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 [PDF]

, 2006
Includes bibliographical references.Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin
Chitapi, Itai
core   +1 more source

From gene to protein - experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension

Frontiers in Physiology, 2014
Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis.
Sheila K Patel, Elena eVelkoska, Melanie eFreeman, Bryan eWai, Terase F Lancefield, Louise M Burrell, Louise M Burrell, Louise M Burrell   +7 more
doaj   +1 more source