Results 41 to 50 of about 25,584,253 (297)

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

bioRxiv, 2020
The emergence of SARS-CoV-2 has created an international health crisis. Small animal models mirroring SARS-CoV-2 human disease are essential for medical countermeasure (MCM) development.
J. Golden, C. Cline, Xian-Kun Zeng, Aura R. Garrison, B. Carey, E. Mucker, L. White, Joshua D. Shamblin, R. Brocato, Jun Liu, April M. Babka, Hypaitia B Rauch, Jeffrey M. Smith, Bradley S Hollidge, Collin J. Fitzpatrick, Catherine V. Badger, J. Hooper   +16 more
semanticscholar   +1 more source

Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells

Circulation, 2021
Ian R. McCracken, BSc(Hons)* Gaye Saginc, PhD* Liqun He, PhD* Alik Huseynov, PhD* Alison Daniels, BSc(Hons)† Sarah Fletcher, PhD† Claire Peghaire , PhD Viktoria Kalna, PhD Maarja Andaloussi-Mäe, PhD Lars Muhl, PhD Nicky M.
I. McCracken, Gaye Saginc, Li-Qun He, A. Huseynov, A. Daniels, S. Fletcher, C. Peghaire, Viktoria Kalna, Maarja Andaloussi-Mäe, L. Muhl, N. Craig, Samantha J. Griffiths, J. Haas, C. Tait-Burkard, U. Lendahl, G. Birdsey, C. Betsholtz, M. Noseda, A. Baker, A. Randi   +19 more
semanticscholar   +1 more source

Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: Evidence of small-study bias [PDF]

, 2006
Background Inappropriate activation of the renin-angiotensin system may play a part in the development of preeclampsia. An insertion/deletion polymorphism within the angiotensin-I converting enzyme gene (ACE-I/D) has shown to be reliably associated with ...
Casas Juan P, Luis A Díaz, Páez, Maria C, Mesa, Clara M, Aroon D Hingorani, Rodrigo Cifuentes, Hingorani, AD, Gonzalez, A, Serrano Norma C, Serrano, Norma C, Monterrosa Alvaro, González, Adriana, Diaz, LA, Serrano, NC, Norma C Serrano, Smeeth, L, Mesa, CM, Monterrosa, Alvaro, Páez Maria C, Cifuentes, Rodrigo, Juan P Casas, Hingorani Aroon D, Díaz Luis A, Smeeth Liam, Mesa Clara M, Casas, Juan P, Adriana González, Díaz, Luis A, Liam Smeeth, González Adriana, Paez, MC, Cifuentes, R, Smeeth, Liam, Casas, JP, Alvaro Monterrosa, Hingorani, Aroon D, Maria C Páez, Cifuentes Rodrigo, Monterrosa, A, Clara M Mesa   +39 more
core   +1 more source

Correlation between plasma-soluble angiotensin-converting enzyme 2, anti- angiotensin-converting enzyme 2, and angiotensin-(1–7) in patients with chronic heart failure

Cardiology Plus, 2019
Background: Angiotensin-converting enzyme 2 (ACE2) is an ACE homolog that converts angiotensin II into angiotensin-(1–7) (Ang-[1–7]). Tumor necrosis factor α (TNF-α), interleukin-1 β, and interleukin-6 are plasma inflammatory cytokines that play a role ...
Yi Gu, Xiao-Hui Yang, Muhammad Nabeel Dookhun, Jian-Song Zhou, Si-Liang Xia, Hui Zhang, Xiao-Yi Qin, Yu-Qing Yang, Jia-Li Cao, Hua-Yi-Yang Zou, Xiao-Qian Xiao, Xin Zheng Lu   +11 more
doaj   +1 more source

Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade

Case Reports in Nephrology, 2020
The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna, Venu Madhav Konala, Subhasish Bose, Sasmit Roy, Bhaskar Reddy Madhira, Vijay Gayam, Srikanth Naramala, Sreedhar Adapa   +7 more
doaj   +1 more source

Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Angiotensin-Converting Enzyme 2 Levels: A Comprehensive Analysis Based on Animal Studies

Frontiers in Pharmacology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the pathogen of coronavirus disease 2019 (COVID‐19), caused the outbreak escalated to pandemic. Reports suggested that near 1–3% of COVID‐19 cases have a fatal outcome.
Gábor Kriszta, Gábor Kriszta, Zsófia Kriszta, Zsófia Kriszta, Szilárd Váncsa, Szilárd Váncsa, Péter Jenő Hegyi, Levente Frim, Bálint Erőss, Péter Hegyi, Péter Hegyi, Gábor Pethő, Gábor Pethő, Erika Pintér   +13 more
doaj   +1 more source

Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2

Microbes and infection, 2020
SARS-CoV-2, the newly identified human coronavirus causing severe pneumonia pandemic, was probably originated from Chinese horseshoe bats. However, direct transmission of the virus from bats to humans is unlikely due to lack of direct contact, implying ...
Ye Qiu, Yuanbo Zhao, Qiong Wang, Jin-Yan Li, Zhi-Jian Zhou, Ce-Heng Liao, Xing-Yi Ge   +6 more
semanticscholar   +1 more source

Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? [PDF]

, 2005
Background Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant.
Montgomery, H, Harding, DR, Devadason David, Humphries, S, Whitelaw, A, David Davedason, Marlow Neil, Montgomery Hugh E, Marlow, N, Hugh E Montgomery, Davedason, D, Andrew Whitelaw, Humphries, SE, Neil Marlow, Montgomery, HE, Whitelaw Andrew, Humphries Steve E, Dhamrait Sukhbir, Devadason, D, Dhamrait, S, Steve E Humphries, Harding David R, David R Harding, Sukhbir Dhamrait   +23 more
core   +1 more source

Protein-protein interactions of human somatic angiotensin-converting enzyme [PDF]

, 2011
In this study, novel disulphide bridges were engineered into the linker region of ACE [Angiotensin-converting enzyme] in an attempt to limit inter-domain movement, thereby producing a candidate for crystallisation and to determine the effect of these ...
Gordon, Kerry
core   +1 more source

Angiotensin-converting enzyme 2: virus accomplice or host defender?

Journal of Bio-X Research, 2023
Objective:. Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to social disruptions, mainly because we know too little about SARS-CoV-2. Methods and Results:.
Jiyan Wang, Hongkai Chang, Yaya Qiao, Huanran Sun, Xichuan Li, Shuofeng Yuan, Shuai Zhang, Changliang Shan   +7 more
doaj   +1 more source