Results 41 to 50 of about 1,615,709 (243)

Angiotensin-converting enzyme inhibitors

Revista Cubana de Cardiología y Cirugía Cardiovascular, 2014
In an updated review concerning the angiotensin-converting enzyme inhibitors, an account of the historical development of this group of drugs proved as highly effective in the treatment of hypertension and of congestive heart failure is made.
David García Barreto, Alberto Toruncha Chuckram   +1 more
doaj  

A Generative Neuro‐Symbolic AI for Protein Sequence Design

Advanced Science, EarlyView.
We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne, Delphine Dessaux, Samuel Buchet, Lucie Barthe, Liza Ammar‐Khodja, Bessam Azizi, Valentin Durante, Gianluca Cioci, Simon de Givry, Alain Roussel, Luis F. Garcia‐Alles, Thomas Schiex, Sophie Barbe   +12 more
wiley   +1 more source

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

TREATMENT ESTIMATION OF DIABETIC NEPHROPATHY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS BY ANGIOTENSIN CONVERTING ENZYME INHIBITORS

Педиатрическая фармакология, 2008
The researchers analyzed the rate and intensity of albuminuria among children and teenagers with type 1 diabetes mellitus (dm1). They studied 4 groups of patients with various diabetes duration: 3 years, from 3 to 5 years, from 5 to 10 years and over 10 ...
V.N. Panfilova, T.E. Taranushenko, O.A. Terent’eva   +2 more
doaj   +2 more sources

ACE-inhibitor induced angioedema masked by nephrotic syndrome

Southwest Respiratory and Critical Care Chronicles, 2016
Angiotensin-converting enzyme (ACE) inhibitors are the leading cause of drug-induced angioedema in the United States because these drugs are widely prescribed for several common medical disorders. Angiotensin-converting enzyme inhibitors cause angioedema
Kenneth Iwuji, Hezekiah Sobamowo, James Tarbox, Rose Egbe   +3 more
doaj  

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Neutrophil hypersegmentation in children receiving angiotensin converting enzyme inhibitors

The Turkish Journal of Pediatrics, 2008
Captopril and enalapril are the most commonly used angiotensin converting enzyme inhibitors in several cardiac diseases in children. On the other hand, the intrinsic renin-angiotensin system in the bone marrow might affect the growth of ...
Vedat Okutan, A Emin Kürekçi, S Umit Sarici, A Avni Atay, Yilmaz Yozgat, Fatih Azik, M Koray Lenk, Okan Ozcan   +7 more
doaj  

Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? [PDF]

, 2005
Background Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant.
Montgomery, H, Harding, DR, Devadason David, Humphries, S, Whitelaw, A, David Davedason, Marlow Neil, Montgomery Hugh E, Marlow, N, Hugh E Montgomery, Davedason, D, Andrew Whitelaw, Humphries, SE, Neil Marlow, Montgomery, HE, Whitelaw Andrew, Humphries Steve E, Dhamrait Sukhbir, Devadason, D, Dhamrait, S, Steve E Humphries, Harding David R, David R Harding, Sukhbir Dhamrait   +23 more
core   +1 more source