Results 51 to 60 of about 1,615,709 (243)

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac Reverse Remodeling: Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The angiotensin‐receptor neprilysin inhibitor (ARNI) sacubitril/valsartan was shown to be superior to the angiotensin‐converting enzyme inhibitor enalapril in terms of reducing cardiovascular mortality in the PARADIGM‐HF (Prospective ...
Yiwen Wang, Ran Zhou, Chi Lu, Qing Chen, Tongda Xu, Dongye Li   +5 more
doaj   +1 more source

DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. [PDF]

, 2012
The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD and cardiovascular disorders (CVD).
Eisenmenger, Wolfgang, Bondy, Brigitta, Mazza, Marianna, Zill, Peter, Clemens Früstück, Brigitta Bondy, Büttner, Andreas, Born, Christoph, Peter Zill, Andreas Büttner, Varallo-Bedarida, Gabriella, Cornelius Schüle, Früstück, Clemens, Rupprecht, Rainer, Möller, Hans-Jürgen, Schüle, Cornelius, Baghai, Thomas C., Wolfgang Eisenmenger, Christoph Born, Rainer Rupprecht, Hans-Jürgen Möller, Thomas C Baghai, Gabriella Varallo-Bedarida   +22 more
core   +1 more source

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Evidence From Randomized Controlled Trials (RCTs) of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II–Receptor Blockers — Questions Remain Unsolved

Journal of Pharmacological Sciences, 2010
Recent randomized controlled trials showed that blockade of the renin–angiotensin system (RAS) by angiotensin-converting enzyme (ACE) inhibitors and angiotensin II–receptor blockers (ARBs) reduced cardiovascular and renal events.
Shinichiro Ueda
doaj   +1 more source

Discontinuation of Heart Failure Pharmacotherapy in Older Adults With Frailty

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Guideline‐directed medical therapy (GDMT) improves outcomes in heart failure irrespective of frailty status. Nevertheless, the magnitude of frailty‐associated discontinuation of GDMT remains insufficiently studied.
Ryo Nakamaru, Shiori Nishimura, Hiraku Kumamaru, Kyohei Daigo, Kayo M. Walsh, Shun Kohsaka   +5 more
doaj   +1 more source

Efficacy of enalapril in the treatment of migraine prophylaxis – A clinical study

National Journal of Physiology, Pharmacy and Pharmacology, 2020
Background: Migraine is the most common problem in the world and few angiotensin-converting enzyme (ACE) inhibitors have previously been shown to be effective in migraine prophylaxis.
Ellabanthini Hima Bindu, Raghuveer B
doaj   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Outcomes in progressive pulmonary fibrosis in systemic autoimmune rheumatic diseases: real‐world data from the ILD‐PRO Registry

Arthritis &Rheumatology, Accepted Article.
Objective We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease‐associated progressive pulmonary fibrosis (SARD‐PPF) and evaluated whether outcomes differed by SARD subtype. Methods The ILD‐PRO Registry is a prospective multicenter US registry of patients with PPF.
Sonali J Bracken, Jeremy M Weber, Megan L Neely, Aparna C Swaminathan, Scott M Palmer, Erin M Wilfong, Ann D Chauffe, Elizabeth R Volkmann   +7 more
wiley   +1 more source

Evaluation Of Clinically Important Drug Interactions Involving Angiotensin-Converting Enzyme Inhibitors Among Cardiac Patients [QP609.A53 F219 2008 f rb]. [PDF]

, 2008
Perencat penukar enzim angiotensin (ACEIs) telah digunakan secara meluas untuk merawat hipertensi dan penyakit kardiovaskular yang lain. Interaksi ubat-ACEI adalah merupakan masalah kesihatan yang signifikan dan perlu penyelidikan lanjut.
Amir Abdelkarim Farag, Omalhassan
core   +1 more source

Standardization of measurement and reporting of medication adherence using the TEN‐SPIDERS tool for claims data

British Journal of Clinical Pharmacology, EarlyView.
This study provides the first open‐source tool to implement the complete TEN‐SPIDERS framework in linked datasets for the determination of the PDC for medication adherence. The TEN‐SPIDERS tool enables transparent, reproducible medication adherence research through automated reporting of all calculation parameters and flexible customization options ...
Adam C. Livori, Tzu‐Yung Kuo, Jenni Ilomäki, Monique F. Kilkenny, Stella Talic, Zanfina Ademi, J. Simon Bell, Jedidiah I. Morton, Lachlan L. Dalli   +8 more
wiley   +1 more source