Advances in the allostery of angiotensin II type 1 receptor
Cell & Bioscience, 2023 Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of high ...
Xi Zhang +4 more
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The angiotensin II type 1 receptor and receptor-associated proteins [PDF]
Cell Research, 2001 The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II.
Deng‐Fu Guo +3 more
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Novel regulations of the angiotensin II receptor type 1 by calmodulin. [PDF]
Biochem Pharmacol, 2018 The angiotensin II receptor type 1 (AT1R) mediates many Ca2+-dependent actions of angiotensin II (AngII). Calmodulin (CaM) is a key transducer of Ca2+ signals in cells. Two locations on the receptor's submembrane domains (SMD) 3 and 4 are known to interact with CaM.
Ehlers K +4 more
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Angiotensin II type 1 receptor expression in human pancreatic cancer and growth inhibition by angiotensin II type 1 receptor antagonist [PDF]
FEBS Letters, 2001 We investigated the expression of angiotensin II type 1 receptor (AT1) in pancreatic cancer. Both AT1 mRNA and protein were expressed in human pancreatic cancer tissues and cell lines. Binding assays showed that pancreatic cancer cells have specific binding sites for angiotensin II and that binding could be eliminated by treatment with a selective AT1 ...
Yoshifumi Fujimoto +3 more
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Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundBoth the adrenergic and renin‐angiotensin systems contribute to orthostatic circulatory homeostasis, which is impaired in postural orthostatic tachycardia syndrome (POTS).
Xichun Yu +9 more
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Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade. [PDF]
PLoS ONE, 2016 Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity.
Kana Tsukuda +12 more
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Downregulation of Angiotensin II Type 1 Receptors During Sepsis [PDF]
Hypertension, 2001 Our study aimed to characterize the mechanisms underlying the attenuated cardiovascular responsiveness toward the renin-angiotensin system during sepsis. For this purpose, we determined the effects of experimental Gram-negative and Gram-positive sepsis in rats.
Michael Bucher +4 more
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Effect of Angiotensin II Type 1 Receptor Blockade on Cardiac Remodeling in Angiotensin II Type 2 Receptor Null Mice [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 To clarify the possible involvement of uninhibited angiotensin II (Ang II) type 2 (AT 2 ) receptor stimulation in the effects of an Ang II type 1 (AT 1 ) receptor blocker, valsartan, we examined the cardiovascular remodeling induced by aortic banding with the use of wild-type ...
Lan Wu +7 more
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Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis [PDF]
Kidney Research and Clinical Practice, 2023 Background Angiotensin II induces glomerular and podocyte injury via systemic and local vasoconstrictive or non-hemodynamic effects including oxidative stress. The release of reactive oxygen species (ROS) from podocytes may participate in the development
Tae-Sun Ha +3 more
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Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism [PDF]
Hormone and Metabolic Research, 2020 AbstractPrimary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA.
Lucie S. Meyer +4 more
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