Results 11 to 20 of about 183,641 (351)

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor–Mediated Cardiomyocyte Autophagy [PDF]

Hypertension, 2009
Autophagy has emerged as an important process in the pathogenesis of cardiovascular diseases, but the proximal triggers for autophagy are unknown. Angiotensin II plays a central role in the pathogenesis of cardiac hypertrophy and heart failure. In this study, we used angiotensin II type 1 (AT 1 ) and type 2 (AT
Porrello, Enzo R., D'Amore, Angelo, Curl, Claire L., Allen, Andrew M., Harrap, Stephen B., Thomas, Walter G., Delbridge, Lea M. D.   +6 more
openaire   +3 more sources

Angiotensin II modulates THP-1-like macrophage phenotype and inflammatory signatures via angiotensin II type 1 receptor

Frontiers in Cardiovascular Medicine, 2023
Angiotensin II (Ang II) is a major component of the renin–angiotensin or renin–angiotensin–aldosterone system, which is the main element found to be involved in cardiopathology.
Tlili Barhoumi, Fatmah A. Mansour, Maroua Jalouli, Hassan S. Alamri, Rizwan Ali, Abdel Halim Harrath, Maha Aljumaa, Mohamed Boudjelal   +7 more
doaj   +1 more source

Angiotensin II Type 1 Receptor Autoantibodies in Primary Aldosteronism [PDF]

Hormone and Metabolic Research, 2020
AbstractPrimary aldosteronism (PA) is the most common form of endocrine hypertension. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been described in transplantation medicine and women with pre-eclampsia and more recently in patients with PA.
Meyer L. S., Gong S., Reincke M., Williams T. A.   +3 more
openaire   +5 more sources

Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?

Molecular Medicine, 2020
Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/
Pawel Namsolleck, Gert N. Moll
doaj   +1 more source

Type 1 angiotensin II receptors in human endometrium [PDF]

Molecular Human Reproduction, 1996
From evidence based on the use of specific receptor subtype antagonists, it has generally been assumed that human uterine tissue contains only type 2 (AT2) angiotensin II (AII) receptor subtype. Using a monoclonal antibody, 6313/G2, directed against a specific sequence in the extracellular domain of the type 1 AII receptor (AT1), in immunocytochemical ...
E, Saridogan, O, Djahanbakhch, J R, Puddefoot, C, Demetroulis, R, Dawda, A J, Hall, G P, Vinson   +6 more
openaire   +2 more sources

Therapeutic targets in the brain for overactive bladder: A focus on angiotensin II type 1 receptor

Journal of Pharmacological Sciences, 2023
Overactive bladder is a condition that affects both men and women, and significantly affects patients' quality of life. Anticholinergics, β3-adrenoceptor agonists, and botulinum toxin are currently being used for treatment.
Shogo Shimizu
doaj   +1 more source

Advances in the allostery of angiotensin II type 1 receptor

Cell & Bioscience, 2023
Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of high ...
Xi Zhang, Suli Zhang, Meili Wang, Hao Chen, Huirong Liu   +4 more
doaj   +1 more source

The angiotensin II type 1 receptor and receptor-associated proteins [PDF]

Cell Research, 2001
The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological actions of Ang II.
D F, Guo, Y L, Sun, P, Hamet, T, Inagami
openaire   +2 more sources

Angiotensin II Type 1 Receptor Blockers [PDF]

Circulation, 2001
In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1 2 Thereafter, the development of pharmacological probes that ...
openaire   +2 more sources

Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki, Masaki Mogi, Jun Iwanami, Li‐Juan Min, Hui‐Yu Bai, Bao‐Shuai Shan, Masayoshi Kukida, Toshifumi Yamauchi, Kana Tsukuda, Harumi Kan‐no, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi   +12 more
doaj   +1 more source