Results 281 to 290 of about 183,641 (351)

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Chronic Kidney Disease in Metabolic Disease: Regulation of SGLT2 and Transcriptomic-Epigenetic Effects of Its Pharmacological Inhibition. [PDF]

Int J Mol Sci
Salvà C, Kaser S, Landolfo M.
europepmc   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Beyond Leptin and Adiponectin: The Diverse Roles of Adipokines in the Myocardial Hypertrophic Process and Heart Failure and Their Potential Contribution in Obesity. [PDF]

Int J Mol Sci
Karmazyn M, Gan XT.
europepmc   +1 more source

Algorithms in Allergy: Hereditary Angioedema

Allergy, EarlyView.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

Bioinformatics-based identification of RAS disequilibrium involved in post-hemorrhagic shock mesenteric lymph return-mediated acute kidney injury in mice. [PDF]

PeerJ
Jin Y, Wang J, Wang S, Li Y, Su K, Feng N, Du H, Zhang L, Yang X, Niu CY, Zhao ZG.   +10 more
europepmc   +1 more source

Angiotensin receptor-neprilysin inhibitors improve the outcome of lung cancer patients with hypertension undergoing immune checkpoint inhibitors treatment. [PDF]

BMC Cardiovasc Disord
Shang C, Wang H, Chen J, Cao S, Sun Y, Sheng Z, Chu T, Zhao L.   +7 more
europepmc   +1 more source

RAAS antagonists dampen the SARS-CoV-2 infection in ex-vivo cultured human precision-cut lung slices. [PDF]

Respir Res
Mahavadi P, Korfei M, Müller-Ruttloff C, Ruppert C, Krauss E, Dorfmüller P, Gattenloehner S, Dimmeler S, El Agha E, Bellusci S, Herold S, Witte B, Ziebuhr J, Guenther A.   +13 more
europepmc   +1 more source

Role of adipocyte angiotensinogen or angiotensin type 1a receptors in the development of diet-induced atherosclerosis or angiotensin II-induced abdominal aortic aneurysms. [PDF]

JVS Vasc Sci
AlSiraj Y, Putnam K, Brunner SI, English VL, Ensor CM, Cassis LA.   +5 more
europepmc   +1 more source