Results 291 to 300 of about 183,641 (351)

Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II

Nature Cell Biology, 2004
The angiotensin II type 1 (AT1) receptor has a crucial role in load-induced cardiac hypertrophy. Here we show that the AT1 receptor can be activated by mechanical stress through an angiotensin-II-independent mechanism. Without the involvement of angiotensin II, mechanical stress not only activates extracellular-signal-regulated kinases and increases ...
Yunzeng, Zou, Hiroshi, Akazawa, Yingjie, Qin, Masanori, Sano, Hiroyuki, Takano, Tohru, Minamino, Noriko, Makita, Koji, Iwanaga, Weidong, Zhu, Sumiyo, Kudoh, Haruhiro, Toko, Koichi, Tamura, Minoru, Kihara, Toshio, Nagai, Akiyoshi, Fukamizu, Satoshi, Umemura, Taroh, Iiri, Toshiro, Fujita, Issei, Komuro   +18 more
openaire   +3 more sources

Nox2+ Myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1.

Cardiovascular Research, 2020
AIMS Heart failure (HF) ensuing myocardial infarction (MI) is characterized by the initiation of a systemic inflammatory response. We aimed to elucidate the impact of myelomonocytic cells and their activation by angiotensin II on vascular endothelial ...
M. Molitor, Wolf-Stephan Rudi, V. Garlapati, S. Finger, Rebecca Schüler, Sabine Kossmann, J. Lagrange, Thanh Son Nguyen, J. Wild, Tanja Knopp, S. Karbach, M. Knorr, W. Ruf, T. Münzel, P. Wenzel   +14 more
semanticscholar   +1 more source

Type 1 angiotensin II receptors of adrenal tumors

Steroids, 1995
The present study was designed to clarify the transcriptional regulation of the human type 1 angiotensin II receptor (AT1) gene and its pathophysiological roles in steroidogenesis by adrenal tumors. A cDNA encoding type 1 angiotensin II receptor (AT1) was isolated from a human liver cDNA library encoding a protein of 359 amino acids with seven ...
H, Nawata, R, Takayanagi, K, Ohnaka, Y, Sakai, K, Imasaki, T, Yanase, S, Ikuyama, S, Tanaka, K, Ohe   +8 more
openaire   +2 more sources

Angiotensin-II receptor type 1 and endothelin-1 receptor type A agonistic autoantibodies in patients with STEMI: new kids on the block

European Heart Journal
The Prognosis after ST-elevation myocardial infarction (STEMI) remains poor. Angiotensin-II and endothelin-1 contribute to adverse prognosis after STEMI through molecular mechanisms that lead to myocardial inflammation, fibrosis and, ultimately ...
G. Civieri, M. Martini, G. Masiero, B. Schiavon, G. Bernava, M. Vadori, L. Iop, M. Perazzolo Marra, A. Cecere, L. Leoni, E. Cozzi, S. Iliceto, F. Tona   +12 more
semanticscholar   +1 more source

Biased Agonism of the Angiotensin II Type 1 Receptor

Mini-Reviews in Medicinal Chemistry, 2012
G protein-coupled receptors (GPCRs) can be activated by multiple ligands and exhibit the capacity to couple to numerous intracellular signal transduction pathways. This property allows GPCRs to be modulated by biased agonists that selectively activate specific subsets of GPCR-regulated cellular signaling proteins.
C M, Godin, S S G, Ferguson
openaire   +2 more sources

Endocytosis and signaling of angiotensin II type 1 receptor

2023
A vasoactive octapeptide angiotensin II (Ang II) hormone is the key regulator of the renin-angiotensin system (RAS). It binds with the two different plasma membrane receptors like angiotensin II type 1 (AT1) and type 2 (AT2) and consequence various biological responses occur. Further, AT1 has two subtypes such as AT1A and AT1B.
openaire   +2 more sources

Angiotensin II Type 1 Receptor Blockade Prevents Alcoholic Cardiomyopathy

Circulation, 2006
Background— Activation of the renin-angiotensin system (RAS) may contribute to the development of alcoholic cardiomyopathy. We evaluated the effect of angiotensin II (Ang II) type 1 receptor (AT 1 ) blockade on the development of alcoholic cardiomyopathy.
Che-Ping, Cheng, Heng-Jie, Cheng, Carol, Cunningham, Zakariya K, Shihabi, David C, Sane, Thomas, Wannenburg, William C, Little   +6 more
openaire   +2 more sources

Angiotensin (1???7) is an antagonist at the type 1 angiotensin II receptor

Journal of Hypertension, 1994
The present study investigated the antagonism of the amino-terminal heptapeptide fragment of angiotensin II ([des-Phe8]-angiotensin II; Ang(1-7)) to angiotensin II (Ang II) both in vitro in rabbit aortae and in vivo in rats.In rabbit isolated endothelium intact aortic rings Ang(1-7) caused a concentration-related rightward displacement of the Ang II ...
J M, Mahon, R D, Carr, A K, Nicol, I W, Henderson   +3 more
openaire   +2 more sources