Results 51 to 60 of about 183,641 (351)
Therapeutic targets of renin-angiotensin system in ocular disorders
Journal of Current Ophthalmology, 2017 Purpose: To review current literature on the renin-angiotensin system (RAS)-mediated pathogenic mechanisms and therapeutic targets in ocular diseases.
Rajesh Choudhary +3 more
doaj +1 more source
Science Signaling, 2018 Bioluminescence-based biosensors enable comprehensive profiling of G protein–coupled receptor signaling bias. Biosensors for GPCR-biased signaling Upon binding to ligands, G protein–coupled receptors (GPCRs) stimulate heterotrimeric G proteins and ...
Y. Namkung +15 more
semanticscholar +1 more source
Hydroxychloroquine Associated With Lower Glomerular Filtration Rate Decline in Lupus Nephritis
Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) protects kidney function in lupus nephritis (LN) by preventing flares, yet some cohort studies show no significant benefit in kidney function with HCQ. Clarifying these conflicting findings by showing early and long‐term benefits of HCQ on kidney function preservation is critical.
Shivani Garg +9 more
wiley +1 more source
Thrombosis Journal, 2003 Background Conflicting results have been reported regarding the association of gene polymorphisms in the renin-angiotensin system (RAS) with different aspects of coronary artery disease (CAD), such as myocardial infarction, neointimal hyperplasia or ...
Helbecque Nicole +5 more
doaj +1 more source
Characterization of a mutant type-1 angiotensin II receptor
Kidney International, 1994 We have used PCR to amplify the rat AT1 receptor from liver mRNA. The receptor DNA was subcloned into pcDNAI and a number of individual clones were transiently expressed in COS-7 cells. These individual receptors were characterized by binding of [125I] Sar1, Ile8-angiotensin II.
Roche, Peter J. +2 more
openaire +2 more sources
Angiotensin II Type 1 Receptor [PDF]
Hypertension, 1998 Abstract—Caveolae are membrane domains that have been implicated in signal transduction, and caveolins are major structural components of these domains. We found that all reported caveolin isoforms (caveolin-1, -2, and -3) were expressed in vascular smooth muscle cells (VSMCs); however, only caveolin-1 mRNA was regulated by angiotensin II (Ang II). Ang
N, Ishizaka +3 more
openaire +2 more sources
Arthritis Care &Research, EarlyView.Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart +14 more
wiley +1 more source
Biomolecules, 2021 Renin–angiotensin systems produce angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7), which are able to induce opposite effects on circulation. This study in vivo assessed the effects induced by Ang II or Ang 1-7 on rat pial microcirculation during ...
Dominga Lapi +14 more
doaj +1 more source
Angiotensin II Type 1 Receptor Antibodies and Increased Angiotensin II Sensitivity in Pregnant Rats [PDF]
Hypertension, 2011 Pregnant women who subsequently develop preeclampsia are highly sensitive to infused angiotensin (Ang) II; the sensitivity persists postpartum. Activating autoantibodies against the Ang II type 1 (AT 1 ) receptor are present in preeclampsia.
Katrin, Wenzel +20 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee +9 more
wiley +1 more source