Results 21 to 30 of about 105,823 (293)

Differential mechanisms of activation of the Ang peptide receptors AT1, AT2, and MAS: using in silico techniques to differentiate the three receptors.

PLoS ONE, 2013
The renin-angiotensin system is involved in multiple conditions ranging from cardiovascular disorders to cancer. Components of the pathway, including ACE, renin and angiotensin receptors are targets for disease treatment.
Jeremy W Prokop, Robson A S Santos, Amy Milsted   +2 more
doaj   +1 more source

Comprehensive genetic screening for vascular Ehlers–Danlos syndrome through an amplification‐based next‐generation sequencing system

American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 37-51, January 2023., 2023
Abstract Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder (HCTD) characterized by arterial dissection/aneurysm/rupture, sigmoid colon rupture, or uterine rupture. Diagnosis is confirmed by detecting heterozygous variants in COL3A1.
Tomomi Yamaguchi, Shujiro Hayashi, Daisuke Hayashi, Takeshi Matsuyama, Norimichi Koitabashi, Kenichi Ogiwara, Masaaki Noda, Chiai Nakada, Shinya Fujiki, Akira Furutachi, Yasuhiko Tanabe, Michiko Yamanaka, Aki Ishikawa, Miyako Mizukami, Asako Mizuguchi, Kazumitsu Sugiura, Makoto Sumi, Hirokuni Yamazawa, Atsushi Izawa, Yuko Wada, Tomomi Fujikawa, Yuri Takiguchi, Keiko Wakui, Kyoko Takano, Shin‐Ya Nishio, Tomoki Kosho   +25 more
wiley   +1 more source

Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms [PDF]

St-Pierre D, et al. (2018), Biochem Pharmacol. 154:104-17, 2019
G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to distinct signaling pathways, continues to be ...
arxiv   +1 more source

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source

Angiotensin II receptor antagonists in hypertension [PDF]

Kidney International, 1998
Blockade of the renin-angiotensin system is now recognized as an effective approach to the treatment of hypertension and congestive heart failure. Today, it is possible to antagonize the effects of angiotensin II more specifically by blocking its receptors by using nonpeptide receptor antagonists.
Michel Burnier, Hans R. Brunner
openaire   +3 more sources

Tetracycline as an inhibitor to the coronavirus SARS-CoV-2 [PDF]

J Cell Biochem (2021) 1-8, 2020
The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address the role of Tetracycline as an inhibitor for the receptor-binding domain (RBD) of the spike protein.
arxiv   +1 more source

Relationship between the expression of angiotensin II receptors type 1 and vasoactive regulators in arterial hypertension

КардиоСоматика, 2020
In the pathogenesis of arterial hypertension (AH), the renin-angiotensin-aldosterone system plays a key role in helping to maintain elevated blood pressure.
Anna V. Logatkina, Viktor S. Nikiforov, Stanislav S. Bondar', Igor' V. Terekhov, Vladimir K. Parfeniuk   +4 more
doaj   +1 more source

Physiological and Biochemical Vascular Reactivity Parameters of Angiotensin II and the Action of Biased Agonist TRV023

Advances in Pharmacological and Pharmaceutical Sciences, 2020
Vascular reactivity experiments using isolated aortic rings have been widely used as a model for physiological and pharmacological studies since the early sixties.
Marcos André Soares Leal, Thanisia de Almeida, João Guilherme Torres, Luciene Cristina Gastalho Campos, Elisardo Corral Vasquez, Valério Garrone Barauna   +5 more
doaj   +1 more source

Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses [PDF]

Pharmacol Res, 136:108-20 (2018), 2019
Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein-coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases. Its functions are mediated through G protein dependent and independent signaling pathways. AT1R has several endogenous peptidic agonists, all derived from angiotensinogen, as
arxiv   +1 more source

Angiotensins and Huntington’s Disease: A Study on Immortalized Progenitor Striatal Cell Lines

Frontiers in Endocrinology, 2017
Neurons from mouse models of Huntington’s disease (HD) exhibit altered electrophysiological properties, potentially contributing to neuronal dysfunction and neurodegeneration.
Walmor C. De Mello, Yamil Gerena, Sylvette Ayala-Peña   +2 more
doaj   +1 more source