Results 1 to 10 of about 50,352 (162)

Drugs to Slow Progression of Chronic Kidney Disease: It’s a Whole New World!

Kidney & Blood Pressure Research
Chronic kidney disease (CKD) affects approximately 14% of adults in the United States and about 10% worldwide and remains a major public health concern.
Jennifer A. Schoonmaker, Bhavna Bhasin-Chhabra, Adam Abow Alkhier, Sundararaman Swaminathan, Musab Hommos   +4 more
doaj   +2 more sources

Angiotensin-converting enzyme inhibitors, angiotensin-II-receptor antagonists and angiotensin-receptor blocker/neprilysin inhibitor utilization in heart failure patients: Sub-analysis of a nation-wide population-based study in the Czech Republic

Biomedical Papers, 2022
Aims. Sub-analysis of a retrospective nation-wide observational analysis of heart failure (HF) epidemiology reported to the Czech National Registry of Reimbursed Health Services between 2012 and 2018 aimed at angiotensin-converting enzyme inhibitors ...
Renata Aiglova, Milos Taborsky, Marie Lazarova, Ludek Pavlu, Josef Danek, Jan Precek, Alexander Schee, Vit Gloger, Vlastimil Cernicek, Marek Vicha, Tomas Skala   +10 more
doaj   +1 more source

Dynamics of endothelial dysfunction, nephropathic and dyslipidemic disorders in patients with insufficient glycemic compensation of type 2 diabetes mellitus during 1 year of application of angiotensin II receptor antagonists for hypertension correction. [PDF]

Medičnì Perspektivi, 2014
The purpose of this study was to determine the dynamics of endothelial dysfunction, nephropathic and dyslipidemic disorders in patients with an insufficient compensation of type 2 diabetes mellitus and hypertension in the correction of blood pressure ...
N. O. Pertseva
doaj   +2 more sources

Difficult choice: angiotensin receptor antagonists

Российский кардиологический журнал, 2013
The paper is focussed on the therapeutic choice of angiotensin receptor antagonists (ARA). The author presents the data on the comparison between different sartans and their benefits which are not explained by the blood pressure reduction.
E. O. Taratukhin
doaj   +1 more source

Angiotensin II receptor antagonists in hypertension [PDF]

Kidney International, 1998
Blockade of the renin-angiotensin system is now recognized as an effective approach to the treatment of hypertension and congestive heart failure. Today, it is possible to antagonize the effects of angiotensin II more specifically by blocking its receptors by using nonpeptide receptor antagonists.
Burnier M, Brunner HR
openaire   +3 more sources

Engineered Mutation of Some Important Amino Acids in Angiotensin II Type 1 (AT1) Receptor Increases the Binding Affinity of AT1-Receptor Antagonists

Journal of Pharmacological Sciences, 2010
The present study was designed to examine the binding affinity and functional potency of selective angiotensin II type 1 (AT1)-receptor antagonists towards specific mutants of AT1 receptor using site-directed mutagenesis.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Masaji Ishiguro, Takashi Nakamura, Takafumi Nagatomo   +4 more
doaj   +1 more source

Monte Carlo optimization based QSAR modeling of angiotensin II receptor antagonists

Acta Chimica Slovenica, 2023
The pathogenesis of essential hypertension, congestive heart failure, and reno-vascular hypertension is related to angiotensin II. This study presents QSAR modeling for a set of compounds acting as angiotensin II receptor antagonists based on the Monte ...
Nemanja Nikolić, Tomislav Kostić, Mlađan Golubović, Tamara Nikolić, Marija Marinković, Velimir Perić, Sara Mladenović, Aleksandar Veselinovic   +7 more
doaj   +1 more source

Internalization of Constitutively Active N111G Mutant of AT1 Receptor Induced by Angiotensin II–Receptor Antagonists Candesartan, Losartan, and Telmisartan: Comparison With Valsartan

Journal of Pharmacological Sciences, 2010
Based on radioligand binding and signal transduction assays in our previous study, we have determined the binding pattern and functional efficacy of the constitutively active mutant N111G of angiotensin II type 1 (AT1) receptor.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Takashi Nakamura, Masanobu Ozaki, Takafumi Nagatomo   +4 more
doaj   +1 more source

DAMAGE OF RENAL FUNCTION AND DYNAMICS OF DYSLIPIDEMIA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH INSUFFICIENT GLYCEMIC COMPENSATION UNDER CONDITION OF CORRECTION OF HYPERTENSION WITH ANGIOTENSIN II RECEPTOR ANTAGONISTS

Український Журнал Нефрології та Діалізу, 2014
Damage of renal function and dynamics of dyslipidemia in patients with type 2 diabetes mellitus with insufficient glycemic compensation under condition of correction of hypertension with angiotensin II receptor antagonists   Introduction.
N.O. Pertseva
doaj   +1 more source

ANGIOTENSIN RECEPTOR ANTAGONISTS: GOING WITH THE TIMES

Кардиоваскулярная терапия и профилактика, 2013
This literature review focuses on the angiotensin II receptor antagonists as one of the new and promising classes of antihypertensive medications. Apart from their antihypertensive activity, these agents possess a number of other beneficial effects.
E. O. Taratukhin
doaj   +1 more source