Results 31 to 40 of about 450,783 (333)

Synthetic nanobodies as angiotensin receptor blockers

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The G protein-coupled receptor (GPCR) family is responsible for regulating much of human physiology, and GPCRs have become the most successful target class for drug development.
Conor McMahon, D. Staus, L. Wingler, Jialu Wang, M. Skiba, Matthias Elgeti, W. Hubbell, H. Rockman, A. Kruse, R. Lefkowitz   +9 more
semanticscholar   +1 more source

Angiogenesis "in vitro" of the healthy mouse heart under hypoxia : the role of Angiotensin II and Nitric Oxide [PDF]

, 2005
Angiogenesis is the process by which blood microvessels are formed from existing ones. Angiogenesis is required for development. It is also important for reducing myocardial hypoxia due to coronary and ischemic heart disease; in myocardial infarction ...
Munk, Veronica Cecilia
core   +1 more source

Tetrazole and Carboxylate Groups of Angiotensin Receptor Antagonists Bind to the Same Subsite by Different Mechanisms (*)

Journal of Biological Chemistry, 1995
To identify specific interactions between either the tetrazole or carboxylate pharmacophores of non-peptide antagonists and the rat AT1 receptor, 6 basic residues were examined by site-directed mutagenesis.
Keita Noda, Y. Saad, A. Kinoshita, Thomas P. Boyle, R. Graham, A. Husain, S. Karnik   +6 more
semanticscholar   +1 more source

Angiotensin II Receptor Antagonists and Hypertension

Clinical and Experimental Hypertension, 1999
Over recent years, a number of imidazole derivatives that specifically bind to the angiotensin II type 1 receptor, thereafter called sartans, have been developed and made available to the clinician. Whether targeting antihypertensive treatment with such a high specificity within the renin cascade may carry major clinical advantage over inhibiting ...
A, Mimran, J, Ribstein, G, DuCailar
openaire   +2 more sources

Treatment of IgA nephropathy; focus on reducing proteinuria by endothelin A receptor antagonists [PDF]

Journal of Nephropathology
IgA nephropathy (IgAN) is the most frequent primary glomerulonephritis throughout world and a leading cause of chronic renal failure across with end-stage kidney failure.
Elham Ahmadipour, Hamid Nasri
doaj   +1 more source

Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization

, 2005
Angiotensin II and aldosterone produce pro-arrhythmic effects by several mechanisms, including the modulation of voltage-dependent K(+) channels involved in human cardiac repolarization.
Tamargo Menéndez, Juan, Delpón Mosquera, María Eva, Caballero Collado, Ricardo, Gómez García, Ricardo, Núñez Fernández, Lucía   +4 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The Use of Dried Blood Spots for the Quantification of Antihypertensive Drugs

International Journal of Analytical Chemistry, 2018
Hypertension or high blood pressure is a harbinger of cardiovascular diseases. There are several classes of drugs used to treat hypertension. This review discusses the use of dried blood spots (DBSs) for the quantification by mass spectrometry (MS ...
Alexander Chernonosov
doaj   +1 more source

THE EFFICACY OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND ANTAGONISTS OF THE RECEPTORS OF THE 1ST TYPE OF ANGIOTENSIN II IN PATIENTS WITH CORONARY ARTERY DISEASE POSTINFARCTION CARDIOSCLEROSIS COMBINED WITH DIABETES MELLITUS TYPE 2 AND ARTERIAL HYPERTENSION

В мире научных открытий, 2016
The article discusses the effectiveness of 3-month therapy with angiotensin converting enzyme inhibitors fosinopril receptor and antagonists of the angiotensin II valsartan to achieve target BP(
Zarina Vyacheslavovna Bitarovа, Oleg Valeryevich Remizov, Zamira Tatarbekovna Astakhova, Zalina Aslanbekovna Toguzova   +3 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source