Results 31 to 40 of about 1,394,594 (296)

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Efficacy of low-dose spironolactone on top of angiotensin receptor blockade in patients with glomerulonephritis

Kidney Research and Clinical Practice, 2018
Background: Previous studies have shown that aldosterone antagonists have a proteinuria-lowering effect in patients with proteinuria and progressive proteinuric disease not adequately controlled by the use of angiotensin receptor blockers (ARBs ...
Byung Chul Yu, Min Sung Lee, Jong Joo Moon, Soo Jeong Choi, Jin Kuk Kim, Seung Duk Hwang, Moo Yong Park   +6 more
doaj   +1 more source

Treatment of IgA nephropathy; focus on reducing proteinuria by endothelin A receptor antagonists [PDF]

Journal of Nephropathology
IgA nephropathy (IgAN) is the most frequent primary glomerulonephritis throughout world and a leading cause of chronic renal failure across with end-stage kidney failure.
Elham Ahmadipour, Hamid Nasri
doaj   +1 more source

Risk Factors, Use of Preventive Drugs, and Cardiovascular Events in Diabetes Mellitus: The PURE Türkiye Cohort

Anatolian Journal of Cardiology, 2023
Background: The risk of cardiovascular disease is correlated with the frequency and control of associated risk factors in diabetes mellitus and may vary according to country.
Aytekin Oğuz, Mustafa Kılıçkap, Sadi Guleç, Yüksel Altuntaş, Kubilay Karşıdağ, Ahmet Temizhan, Özge Telci Çaklılı, Kevser Burcu Tümerdem Çalık, Miraç Vural Keskinler, Sumathy Rangarajan, Salim Yusuf   +10 more
doaj   +1 more source

Hepatic Mitochondrial Renin-Angiotensin Systems [PDF]

, 2015
Introduction: The circulating renin-angiotensin system (RAS) was originally described as a key endocrine regulator of intravascular homeostasis; however, the existence of a local (tissue) RAS has become increasingly reported in a variety of tissues ...
Skipworth, JRA
core  

Guanosine nucleotides regulate B2 kinin receptor affinity of agonists but not of antagonists: Discussion of a model proposing receptor precoupling to G protein [PDF]

, 2000
The effect of nucleotides on binding of the B2 kinin (BK) receptor agonist {[}H-3]BK and the antagonist {[}H-3]NPC17731 to particulate fractions of human foreskin fibroblasts was studied.
Er Faussner, Faussner, Alexander, Adelbert A. Roscher, Roscher, Adelbert A.   +3 more
core   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Nonpeptide angiotensin II-receptor antagonists.

Japanese Journal of Pharmacology, 1994
The renin-angiotensin system (RAS) is known to play a very important role in cardiovascular diseases. The present state of the research on orally active nonpeptide angiotensin II (A II)-receptor antagonists and their pharmacological characterization will be reviewed.
Y, Inada, T, Wada, Y, Shibouta, K, Nishikawa   +3 more
openaire   +2 more sources

Angiotensin II, angiotensin II antagonists and spironolactone and their modulation of cardiac repolarization

, 2005
Angiotensin II and aldosterone produce pro-arrhythmic effects by several mechanisms, including the modulation of voltage-dependent K(+) channels involved in human cardiac repolarization.
Tamargo Menéndez, Juan, Delpón Mosquera, María Eva, Caballero Collado, Ricardo, Gómez García, Ricardo, Núñez Fernández, Lucía   +4 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source