Results 1 to 10 of about 5,897 (227)

Electrostatic Activation of Tetrazoles [PDF]

The Journal of Organic Chemistry, 2020
Photoactivation of tetrazoles to form nitrile imines primed for 1,3-dipolar cycloaddition reactions is of widespread utility in chemistry. In contrast, the corresponding thermal reactions usually possess prohibitively high barriers and have garnered significantly less attention.
Vincent Doan, Benjamin B. Noble, Michelle L. Coote   +2 more
openaire   +5 more sources

Multi-Gram Synthesis of Enantiopure 1,5-Disubstituted Tetrazoles Via Ugi-Azide 3-Component Reaction

Molecules, 2018
Tetrazoles have been widely studied for their biological properties. An efficient route for large-scale synthesis of 1,5-disubstituted tetrazoles (1,5-DTs) is presented.
Pietro Capurro, Lisa Moni, Andrea Galatini, Christian Mang, Andrea Basso   +4 more
doaj   +2 more sources

Mechanistic DFT Study of 1,3-Dipolar Cycloadditions of Azides with Guanidine

Molecules, 2023
Density functional calculations SMD(chloroform)//B3LYP/6-311+G(2d,p) were employed in the computational study of 1,3-dipolar cycloadditions of azides with guanidine.
Ivana Antol, Zoran Glasovac, Davor Margetić   +2 more
doaj   +1 more source

Synthesis of new bile acid-fused tetrazoles using the Schmidt reaction

Beilstein Journal of Organic Chemistry, 2021
A practical and high-yielding Schmidt reaction for the synthesis of fused tetrazoles from bile acid precursors was developed. Mild reaction conditions using TMSN3 instead of hydrazoic acid as an azide source produced good yields of the desired tetrazoles.
Dušan Đ. Škorić, Olivera R. Klisurić, Dimitar S. Jakimov, Marija N. Sakač, János J. Csanádi   +4 more
doaj   +1 more source

Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores

Molecules, 2022
N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Mäser, Marcel Kaiser, Robert Weis   +8 more
doaj   +1 more source

Ultrasound-Assisted Ugi-Azide Multicomponent Reaction for the Synthesis of 1,5-Disubstituted Tetrazoles

Chemistry Proceedings, 2023
The Ugi-azide MCR (UA) is one of the most efficient methods for the synthesis of 1,5-disubstituted-1H-tetrazoles (1,5-DS-T). Complex drug-like scaffolds incorporating tetrazoles have demonstrated a wide range of therapeutic benefits such as anti ...
Alejandro Corona-Díaz, Sandra C. Ramírez-López, David Calderón-Rangel, Cristian Saldaña-Arredondo, Rocío Gámez-Montaño   +4 more
doaj   +1 more source

Selective synthesis of ureas and tetrazoles from amides controlled by experimental conditions using conventional and microwave irradiation

Journal of Saudi Chemical Society, 2018
An efficient synthetic procedure has been achieved for selective synthesis of 1,5-disubstituted tetrazoles and diaryl ureas from secondary amides in situ in the presence of NaN3 and POCl3 as solvent, both by conventional and microwave methods.
Rajendran Sribalan, Andiappan Lavanya, Maruthan Kirubavathi, Vediappen Padmini   +3 more
doaj   +1 more source

Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase

Molecules, 2018
The aim of the present study was to broaden the structure-activity relationships of C- and N-β-d-glucopyranosyl azole type inhibitors of glycogen phosphorylase.
Sándor Kun, Éva Bokor, Ádám Sipos, Tibor Docsa, László Somsák   +4 more
doaj   +1 more source

Synthesis of α-Sulfoximino Tetrazoles via Azido-Ugi Four-Component Reaction

SynOpen, 2022
The sulfoximine-based tetrazoles have been synthesized via azido-Ugi four-component reactions of sulfoximines, isocyanides, aldehydes, and TMS-azide in MeOH at 70 °C in the presence of InCl3.
C. P. Irfana Jesin, Ramesh Kataria, Ganesh Chandra Nandi   +2 more
doaj   +1 more source

Synthesis, structure and characterisation of late transition metal complexes with 2-(tetrazol-1-yl)pyridine

Журнал Белорусского государственного университета: Химия, 2022
Complexes [MII(2-pytz)Cl2] (M(II) = Pt, Pd; 2-pytz = 2-(tetrazol-1-yl)pyridine) were synthesised via direct interaction of the corresponding metal chlorides (K2PtCl4 or PdCl2) with 2-pytz under ambient conditions.
Tatiyana V. Serebryanskaya, Hanna A. Belavusava, Yuri V. Grigoriev, Sergei V. Voitekhovich, Ludmila S. Ivashkevich, Oleg A. Ivashkevich   +5 more
doaj   +1 more source