Results 21 to 30 of about 5,247 (179)

Metal-Free Regioselective N²‑Arylation of 1H‑Tetrazoles with Diaryliodonium Salts

, 2022
We describe a simple, metal-free regioselective N2-arylation strategy for 5-substituted-1H-tetrazoles with diaryliodonium salts to access 2-aryl-5-substituted-tetrazoles.
Raktim Abha Saikia (13113146), Ashim Jyoti Thakur (13113149), Anurag Dutta (11972124), Bipul Sarma (604086)   +3 more
core   +1 more source

Expedient Discovery of a Metallaphotoredox Cyanomethylation for Synthesizing α‐Aryl Nitriles

Chemistry – A European Journal, EarlyView.
A metallaphotoredox cyanomethylation reaction has been developed for the synthesis of valuable α‐aryl nitrile intermediates. The methodology was successfully applied to diverse medicinally‐relevant substrates, providing an expedient route to anti‐cancer Senexin compounds, while also removing the need for toxic cyanide reagents. The mechanism was probed
Gemma C. Cook, Blandine McKay, Craig Jamieson, Lee J. Edwards, Charlotte Harriman, Zackary S. Read, Simon T. Bate   +6 more
wiley   +1 more source

Catalyst‐Free Cyanation of Arenes by Acetonitrile in a Plasma–Liquid Microreactor

Chemistry – A European Journal, EarlyView.
An original approach of arylnitrile synthesis was developed by generating an argon plasma in contact with solutions of arene in acetonitrile within a gas‐liquid microreactor. Plasma activation of acetonitrile generated cyano radicals, enabling a catalyst‐free C‐H cyanation of arenes.
Pierre Dedieu, Gabriel Morand, Stéphanie Ognier, Alain Favre‐Réguillon, Michael Tatoulian   +4 more
wiley   +1 more source

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, EarlyView.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source

Visible-Light-Driven Iron-Catalyzed Intermolecular Benzylic C(sp³)–H Amination with 1,2,3,4-Tetrazoles

A visible-light-driven iron-catalyzed C(sp3)–H amination of diphenylmethane derivatives with 1,2,3,4-tetrazoles under mild conditions has been developed. The reaction proceeds with photosensitizer-free conditions and features satisfactory to good yields.
Junhao Hu (6293501), Changhua Chen (17796990), Xiaoqiang Yu (128293), Yan Du (229593), Yarong Wang (341594), Jing-Jing Tang (11641881), Yang Li (7082), Jiangli Fan (1409731), Ming Bao (1617106), Zhonggui Xiong (17796993)   +9 more
core   +1 more source

Redox Properties of Catalytically Generated Iminium Ions From α,β‐Unsaturated Aldehydes and Chiral Secondary Amines

European Journal of Organic Chemistry, EarlyView.
We present a rapid, operationally simple, and broadly applicable protocol for the catalytic formation and in situ electrochemical characterization of chiral a,b‐unsaturated iminium ions by cyclic voltammetry (CV). Using only 5 mol% of the aminocatalyst, we systematically measure the reduction potential of over 50 iminium intermediates, revealing how ...
Martí Gisbert, Paula Rodríguez, Xavier Companyó   +2 more
wiley   +1 more source

Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines

, 2019
A new methodology to synthesize 2,6-di-, and 2,2′,6-trisubstituted morpholines via the reduction of oxabicyclic tetrazoles under mild conditions is described.
Edouard Duchamp (6877256), Benoit Deschênes Simard (6877259), Stephen Hanessian (1462600)   +2 more
core   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

1-Isocyanomethylbenzotriazole and 2,2,4,4-tetramethylbutylisocyanide-cleavable isocyanides useful for the preparation of α-aminomethyl tetrazoles

, 2006
1-Isocyanomethylbenzotriazole and 2,2,4,4-tetramethylbutylisocyanide smoothly undergo Ugi type reaction toward 1,5-disubstituted aminomethyl tetrazoles and can be subsequently cleaved under acidic conditions yielding substituted α-aminomethyl tetrazoles.
Alexander Doemling, Dömling, Alexander, Barbara Beck, Marina Magnin‐Lachaux, Magnin-Lachaux, Marina, Beck, Barbara   +5 more
core   +1 more source

Microporous Self‐Assembled Pd(II) Tetrahedral Cages for Rapid and Reversible Multi‐Phase Sequestration of Iodine and Methyl Iodide

Small, EarlyView.
This work reports a family of microporous, self‐assembled tetrahedral coordination cages that efficiently capture iodine, polyiodides, and methyl iodide from vapor, aqueous, and organic media. The cages display exceptional uptake capacities, rapid kinetics, and high selectivity, enabling the first dynamic vapor‐phase iodine capture by coordination ...
Raghunath Singha, Risikeshan Pradhan, Monotosh Dalapati, Pijush De, Debashree Manna, Dipak Samanta   +5 more
wiley   +1 more source