Results 41 to 50 of about 18,306 (270)

New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum [PDF]

, 2018
Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs.
A Gómez-Zavaglia, A Ismael, A Ismael, A Paulo, A Siriwardana, AM Dondorp, AM Dondorp, António Sebastião Rodrigues, B Weniger, B Witkowski, B Witkowski, Bruno Guerreiro, C Amaratunga, C Amaratunga, D Ménard, EA Ashley, ES Schaffert, F Ariey, F Nogueira, F Teuscher, Fatima Nogueira, FG Baptista, H Noedl, H Noedl, H Singh, HM Ismail, I Fernández, J Adamec, J Jourdan, J Straimer, J Straimer, J Straimer, J Straimer, JL Vennerstrom, K Chauhan, K Chauhan, K Chotivanich, KM Tun, L Lobo, LH Carvalho, Lis Lobo, Lília I. L. Cabral, M Drąg-Zalesińska, M Machado, M Mota, M Tukulula, MA Fügi, Maria Inês Sena, Maria L. S. Cristiano, MD Spring, N Thuy-Nhien, NCP Araújo, PB Mohite, PM O’Neill, PN Soh, RJ Herr, RS Upadhayaya, S Arulmurugan, S Chaorattanakawee, S Nwaka, S Takala-Harrison, S Takala-Harrison, SA Santos, SD Fontaine, T Yang, TNC Wells, Valter Ferreira de Andrade-Neto, VS de Sena Pereira, W Peters, WA Kite, World Health Organization, X Fan, Y Lubell, Y Tang, Z Li, Z Wang   +75 more
core   +2 more sources

Corrosion Inhibition of Copper in Non-polluted and Polluted Sea Water Using 5-phenyl-1-H-tetrazole

International Journal of Electrochemical Science, 2012
Corrosion inhibition of copper in salt water using 5-phenyl-1-H tetrazole (PTAH) was investigated. Experiments were also performed in salt water polluted with thiosulfate or sulfide ions.
F.M. Al Kharafi, I.M. Ghayad, R.M. Abdullah   +2 more
doaj   +1 more source

Design, synthesis, in silico toxicity prediction, molecular docking, and evaluation of novel pyrazole derivatives as potential antiproliferative agents [PDF]

, 2016
A new series of pyrazole derivatives were designed by docking into vascular endothelial growth factor receptor-2 (VEGFR-2) kinase active site. The designed compounds were synthesized and evaluated for in vitro antiproliferative activity against HT-29 ...
Chandra, Narendra Sharath JN, Kolli, Swetha, Paturi, Manichandrika, Ravula, Parameshwar, Vamaraju, Harinadha Babu   +4 more
core   +1 more source

Light-Activatable, 2,5-Disubstituted Tetrazoles for the Proteome-wide Profiling of Aspartates and Glutamates in Living Bacteria

ACS Central Science, 2019
Covalent inhibitors have recently seen a resurgence of interest in drug development. Nevertheless, compounds, which do not rely on an enzymatic activity, have almost exclusively been developed to target cysteines. Expanding the scope to other amino acids
Kathrin Bach, Bert L. H. Beerkens, Patrick R. A. Zanon, S. Hacker   +3 more
semanticscholar   +1 more source

Recent Advances in the Synthesis of 5-Substituted 1H-Tetrazoles: A Complete Survey (2013–2018)

Synthesis, 2019
Tetrazoles are synthetic organic heterocyclic compounds comprising of high nitrogen content among stable heterocycles. Tetrazoles, chiefly 5-substituted 1H-tetrazoles have been used as a bioisosteric replacement for carboxylic acids in medicinal ...
Rupali Mittal, S. Awasthi
semanticscholar   +1 more source

Novel Therapeutic Approaches to Invasive Candidiasis: Considerations for the Clinician

Infection and Drug Resistance, 2023
Frederic Lamoth1,2 1Infectious Diseases Service, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; 2Institute of Microbiology, Department of Laboratory Medicine and Pathology, Lausanne University ...
Lamoth F
doaj  

Tetrazoles: A multi-potent motif in drug design.

European journal of medicinal chemistry
The unique physicochemical properties and fascinating bioisosterism of tetrazole scaffolds have received significant attention in medicinal chemistry. We report recent efforts using tetrazoles in drug design strategies in this context.
Ye Yuan, Mu Li, Vasso Apostolopoulos, John M Matsoukas, Wojciech M. Wolf, M. Blaskovich, Joanna Bojarska, Z. Ziora   +7 more
semanticscholar   +1 more source

In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB [PDF]

, 2018
In the context of antibacterial drug discovery resurgence, novel therapeutic targets and new compounds with alternative mechanisms of action are of paramount importance. We focused on UDP-N- acetylenolpyruvylglucosamine reductase (i.e.
Barreteau, Hélène, Dowson, Christopher G., Gobec, Stanislav, Hrast, Martina, Jukič, Marko, Patin, Delphine, Roper, David I., Tod, Julie   +7 more
core   +3 more sources

Highly Active and Reusable Cu/C Catalyst for Synthesis of 5-Substituted 1H-Tetrazoles Starting from Aromatic Aldehydes

Acta Chimica Slovenica, 2020
A new, efficient and convenient method for the synthesis of 5-substituted 1H-tetrazole derivatives with a wide range of substituents in good to excellent yields has been developed.
Reza Khalifeh, Najme Rastegar, Dariush Khalili   +2 more
doaj   +1 more source

Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids

Frontiers in Pharmacology
The triazole antifungals posaconazole and itraconazole can cause pseudohyperaldosteronism with hypertension and hypokalemia, edema, and gynecomastia by inhibiting steroid synthesis and metabolism.
Marie-Christin Jäger, Marie-Christin Jäger, Víctor González-Ruiz, Víctor González-Ruiz, Friedrich L. Joos, Friedrich L. Joos, Denise V. Winter, Julien Boccard, Julien Boccard, Thorsten Degenhardt, Steve Brand, Serge Rudaz, Serge Rudaz, George R. Thompson, Alex Odermatt, Alex Odermatt   +15 more
doaj   +1 more source