Results 61 to 70 of about 5,247 (179)

N-Morpholinomethyl-5-lithiotetrazole: A Reagent for the One-Pot Synthesis of 5‑(1-Hydroxyalkyl)tetrazoles

, 2019
An efficient, one-pot method for the preparation of 5-(1-hydroxyalkyl)­tetrazoles is reported. N-Morpholinomethyl-5-lithiotetrazole, generated by the deprotonation of 4-(N-tetrazolylmethyl)­morpholine with LiHMDS, undergoes addition to ketones and ...
Panagiotis D. Alexakos (7388786), Duncan J. Wardrop (475616)   +1 more
core   +1 more source

Transition-Metal-Free Direct Alkylation of Aryl Tetrazoles via Intermolecular Oxidative C–N Formation

, 2016
A transition-metal-free synthetic approach for constructing alkylated aryl tetrazoles has been developed using n-Bu4NI as the catalyst and t-BuOOH as the oxidant. It involves the direct C–N bond formation through sp3 C–H activation.
Liang Wang (23021), Kaiqiang Zhu (1709980), Mingyang He (1591807), Qun Chen (313764)   +3 more
core   +1 more source

α‐Hydroxy‐Tetrazoles as Latent Ethynyl Moieties: A Mechanistic Investigation

, 2018
International audienceWe report here on the dehydration of α‐hydroxy‐tetrazoles (AHTs) to yield ethynes via a vinyl carbene. The mechanism has been scrutinized by examination of the substrate and/or dehydrating agent scope and by PCM/PBE0/6‐31++G(d,p ...
Bruno Drouillat, Wright, Karen, Oleg N. Burov, Drouillat, Bruno, Burov, Oleg, Lisovin, Anton., Pierre Quinodoz, Quinodoz, Pierre, Anton. V. Lisovin, François Couty, Mikhail E. Kletskii, Couty, François, Karen Wright, Kletskii, Mikhail   +13 more
core   +1 more source

1,5-Disubstituted Tetrazoles as Promising Anticancer Resistance Agents: A Chemoinformatic Characterization. [PDF]

ACS Omega
Garibay-Manríquez C, Díaz-Cervantes E, Chacón-García L, Martinez-Mayorga K, Cortés-García CJ.   +4 more
europepmc   +1 more source

Recent advances in multicomponent synthesis of 5-substituted 1<i>H</i>-tetrazoles from aldehydes: catalytic methods and green chemistry approaches. [PDF]

RSC Adv
Hsu CY, Altalbawy FMA, Asiri M, Abosaoda MK, Ballal S, Singh A, Nanda A, Ray S, Hussein AR, Baqir SJ.   +9 more
europepmc   +1 more source

Tetrazolylidene-Stabilized Gold(I) Complexes: Synthesis and Evaluation of Anticancer Activity <i>In Vitro</i>. [PDF]

Inorg Chem
Stifel S, Schmidt C, Richter LF, Pöthig A, Casini A, Kühn FE.   +5 more
europepmc   +1 more source

One-Pot Bioisosteric Replacement of Alkyl Carboxylic Acids via Organic Photoredox Catalysis. [PDF]

Org Lett
Haney BA, Merriman MT, Qian S, Nicewicz DA.   +3 more
europepmc   +1 more source

Thermocatalytic Transformation of Nitriles Utilizing Pristine and Calcined ZnCr Layered Double Hydroxides for the Synthesis of Various Tetrazole- and Kynurenic Acid-Based Drug Candidates. [PDF]

ACS Omega
Alsoliman H, Szabados M, Bélteky P, Kónya Z, Szatmári I, Mészáros R.   +5 more
europepmc   +1 more source

Tetrazoles: A multi-potent motif in drug design

The unique physicochemical properties and fascinating bioisosterism of tetrazole scaffolds have received significant attention in medicinal chemistry. We report recent efforts using tetrazoles in drug design strategies in this context.
J Matsoukas (22499255), MAT Blaskovich (16259207), Y Yuan (7724597), M Li (3216264), Vasso Apostolopoulos (19480216), J Bojarska (22499261), WM Wolf (22499258), ZM Ziora (22499264)   +7 more
core  

Green synthesis of 5-substituted-1h-1,2,3,4-tetrazoles and 1-sustituted-1h-1,2,3,4-tetrazoles via [3+2] cycloaddition by reusable immobilized alcl3 on γ–al2o3

, 2016
: We report the effectiveness of the surface modified γ-Al2O3 which is reusable, efficient, catalytic, safe and environmentally acceptable procedure for the conversion of both alkyl and aryl nitriles into the corresponding 5-substituted-1H-1,2,3,4 ...
Abrahamse, Heidi, Nanjundaswamy, Hemmaragala Marishetty   +1 more
core