Results 71 to 80 of about 18,306 (270)

Computationally motivated synthesis and enzyme kinetic evaluation of N-(β-d-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors [PDF]

, 2015
Following our recent study of N-(β-D-glucopyranosyl)-oxadiazole-carboxamides (Polyák et al., Biorg. Med. Chem. 2013, 21, 5738) revealed as moderate inhibitors of glycogen phosphorylase (GP), in silico docking calculations using Glide have been performed ...
Alex, Arunan, Benltifa, Bokor, Broggini, Brownlee, Carta, Cheng, Cho, Chrysina, Condi, Danaei, Docsa, Fischer, Francl, Friesner, Hayes, Hayes, Hehre, Huisgen, Huisgen, Huisgen, Jorgensen, Jorgensen, Kaminski, Kantsadi, Kantsadi, Kenny, Koldobskii, Kun, Lagorce, Lipinski, Lonsdale, Marten, Murray, Murray, Nagy, Nagy, Oikonomakos, Paolini, Polya, Polyák, Pospisil, Potts, Potts, Smith, Somsák, Somsák, Somsák, Somsák, Still, Tannor, Veber, Woon, Zhao, Zhong, Zhou, Ősz   +57 more
core   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Facile synthesis of tetrazoles catalyzed by the new copper nano-catalyst

Green Chemistry Letters and Reviews, 2020
Despite various methods for preparation of tetrazoles, they are suffering from some disadvantages such as low yield, long reaction times and harsh reaction conditions, and there are still high demands to improve the common procedures to solve problems ...
Vahideh Khorramabadi, Davood Habibi, Somayyeh Heydari   +2 more
doaj   +1 more source

Predicting Solid-State Heats of Formation of Newly Synthesized Polynitrogen Materials by Using Quantum Mechanical Calculations [PDF]

, 2008
We present density functional theory level predictions and analysis of the basic properties of newly synthesized high-nitrogen compounds together with 3,6-bis(2H-tetrazol-5-yl)-1,2,4,5-tetrazine (BTT) and 3,3′-azobis(6-amino-1,2,4,5-tetrazine) (DAAT ...
Abou-Rachid, H., Dudiy, S., Goddard, W. A., III, Hu, A., Song, Y., Zybin, S. V.   +5 more
core   +1 more source

AhBWR15, A Novel RLK Gene, Confers Resistance to Ralstonia solanacearum in Peanut

Plant Biotechnology Journal, EarlyView.
ABSTRACT Bacterial wilt (BW), a severe soil‐borne disease caused by Ralstonia solanacearum, significantly impedes global peanut production. Despite its impact, the mechanisms underlying BW resistance in peanut remain unclear. Herein, we selected the highly resistant variety Nongdahua108 (H108) and the susceptible variety Nongdahua107 (H107) to develop ...
Zenghui Cao, Kai Zhao, Hao Li, Xingli Ma, Di Cao, Yanzhe Li, Sasa Hu, Qian Ma, Yaoyao Li, Yi Fan, Mengtian Hou, Kunkun Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Rui Ren, Dongmei Yin   +16 more
wiley   +1 more source

Inactivation of anandamide signaling : A continuing Debate [PDF]

, 2010
Copyright 2011 Elsevier B.V., All rights reserved.Peer reviewedPublisher ...
Ahluwalia, Ahn, Alexander, Alexander, Beltramo, Bhave, Bifulco, Bisogno, Bisogno, Bosier, Cadas, Chen, Chuang, Clapper, Cravatt, Cravatt, Cristino, Day, De Petrocellis, De Petrocellis, De Petrocellis, Desarnaud, Deutsch, Deutsch, Devane, Devane, Di Carlo, Di Marzo, Di Marzo, Di Marzo, Egertova, Evans, Evans, Evans, Fedorova, Glaser, Guzmán, Hampson, Hanus, Harizi, Hesham Khairy, Hillard, Hillard, Hillard, Horvath, Howlett, Howlett, Iversen, Jarrahian, Jiang, Jonsson, Kaczocha, Kaczocha, Katayama, Kathuria, Khairy, Klein, Koutek, Kulkarni-Narla, Liu, Long, Maccarrone, Malcher-Lopes, Matsuda, McFarland, Mechoulam, Mechoulam, Mechoulam, Mechoulam, Miller, Moore, Mulder, Munro, Numazaki, Okamoto, Ortar, Pertwee, Piomelli, Poling, Porter, Premkumar, Randall, Schlosburg, Schmid, Simon, Stella, Stremmel, Sun, Sun, Sánchez, Thomas, Thors, Tian, Tsou, Tsuboi, Ueda, Ueda, Van den Bossche, Van Der Stelt, Wael E. Houssen, Walker, Weber, Wenger, Wood, Woodward, Yu, Zygmunt   +106 more
core   +3 more sources

Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161

Antimicrobial Agents and Chemotherapy, 2019
VT-1161 and VT-1598 are promising investigational tetrazole antifungals that have shown in vitro and in vivo activity against Candida and other fungi.
A. Nishimoto, S. Whaley, N. Wiederhold, Qing Zhang, C. Yates, W. Hoekstra, R. Schotzinger, E. Garvey, P. Rogers   +8 more
semanticscholar   +1 more source

Substrate selectivity of human histidine methyltransferase METTL9

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Methylation of histidine residues in zinc transporters by histidine methyltransferase METTL9 plays an important role in modulating their metal‐binding properties. Here, we report synthetic, enzymatic, and computational studies on human METTL9‐catalyzed Nπ‐methylation of His375 in zinc transporter SLC39A5‐derived peptides in which the histidine
Sadaf Ahmad, Laust Moesgaard, Christian W. Tornøe, Paulina Emmel, Klaudia Slusarczyk, Jakub Drozak, Jacob Kongsted, Jasmin Mecinović   +7 more
wiley   +1 more source

A Crystallographic Study of a Novel Tetrazolyl-Substituted Nitronyl Nitroxide Radical

Crystals, 2018
Spin-labelled compounds are widely used in chemistry, physics, biology, and material sciences, but the directed synthesis of some functionalized organic radicals is still a challenge.
Vasily E. Romanov, Irina Yu. Bagryanskaya, Dmitry E. Gorbunov, Nina P. Gritsan, Elena V. Zaytseva, Dominique Luneau, Evgeny V. Tretyakov   +6 more
doaj   +1 more source

Synthesis of N4-aryl-β-d-glucopyranosylcytosines: a methodology study [PDF]

, 2015
A number of leaving groups, including arylsulfonates, triazoles, 3-nitrotriazoles, and tetrazoles, have been studied for the substitution reaction by aryl and alkyl amines at the 4-position of β-d-glucopyranosyluracils. Examination of the stability, ease
Eugenia Smyrli, Evangelia D. Chrysina, Michael Mamais, Paschalis Grammatopoulos, Thanasis Gimisis, Virginia Kouloumoundra   +5 more
core   +1 more source