Results 71 to 80 of about 5,897 (227)

Oxadiazolone‐Triazole Derivatives as a New Scaffold for Modulation of Angiotensin II‐Induced Vascular Contraction

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
A novel series of candidate AT1 receptor antagonists based on oxadiazolone‐triazole scaffolds was designed and synthesized. Most compounds reduced angiotensin II‐induced vascular contraction in an initial biological screening, with compound 7f emerging as the most active derivative.
Larissa F. L. Ferreira, Daiana G. de A. Vasconcelos, Ruth C. A. Santos, Jivaldo G. Ferreira, Alice V. Araújo, Janaína V. dos Anjos   +5 more
wiley   +1 more source

Computational Design and Theoretical Evaluation of Novel Heterocyclic Energetic Materials Based on 5‐H‐Imidazo‐[4,5‐c]‐Pyridazine and 1,2,4‐Triazolo‐[4,3‐a]‐Pyrazine Scaffolds

Journal of Computational Chemistry, Volume 47, Issue 23, September 5, 2026.
Eighty‐eight novel energetic compounds based on 5‐H‐imidazo‐[4,5‐c]pyridazine and 1,2,4‐triazolo‐[4,3‐a]pyrazine scaffolds, functionalized with nitro, nitramino, azido, and nitrate ester groups, were theoretically evaluated by DFT. Nine candidates surpassed RDX in density and detonation performance while maintaining acceptable impact sensitivity.
Luciana Amorim da Silva, Nathália Magalhães Paixão Rosa, Danillo Fernando Vianna Cantini, Aline Cardoso Anastácio   +3 more
wiley   +1 more source

Die Jekyll‐und‐Hyde‐Natur von Tetrazolen in der Polymerwissenschaft: Von der intrinsischen elektronischen Dualität zur programmierbaren makromolekularen Funktion

Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.
Ein Heterocyclus – drei elektronische Identitäten. Dieses Minireview zeigt, wie das Substitutionsmuster von Tetrazolen deren Funktion in Polymeren bestimmt und eröffnet substitutionsdefinierte Designprinzipien für funktionelle Polymermaterialien. ZUSAMMENFASSUNG Die Natur vereint Stabilität und Responsivität in einzelnen molekularen Gerüsten und ...
Meryem S. Akdemir, Hatice Mutlu
wiley   +1 more source

Functionalized Amide Chlorides: 5-Dimethylamino-1H-Tetrazoles from N,N-Dimethyl-Azidochloromethylenimonium Chloride and Primary amines

CHIMIA, 1975
Sodium azide or trimethylsilylazide react with N,N-dimethylphosgenimonium chloride by monosubstitution yielding N,N-dimethyl-azidochloromethylen-imonium chloride which can be isolated.
H.G. Viehe, P. George
doaj   +1 more source

Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines

, 2019
A new methodology to synthesize 2,6-di-, and 2,2′,6-trisubstituted morpholines via the reduction of oxabicyclic tetrazoles under mild conditions is described.
Edouard Duchamp (6877256), Benoit Deschênes Simard (6877259), Stephen Hanessian (1462600)   +2 more
core   +1 more source

Metal-Free Regioselective N²‑Arylation of 1H‑Tetrazoles with Diaryliodonium Salts

, 2022
We describe a simple, metal-free regioselective N2-arylation strategy for 5-substituted-1H-tetrazoles with diaryliodonium salts to access 2-aryl-5-substituted-tetrazoles.
Raktim Abha Saikia (13113146), Ashim Jyoti Thakur (13113149), Anurag Dutta (11972124), Bipul Sarma (604086)   +3 more
core   +1 more source

1-Isocyanomethylbenzotriazole and 2,2,4,4-tetramethylbutylisocyanide-cleavable isocyanides useful for the preparation of α-aminomethyl tetrazoles

, 2006
1-Isocyanomethylbenzotriazole and 2,2,4,4-tetramethylbutylisocyanide smoothly undergo Ugi type reaction toward 1,5-disubstituted aminomethyl tetrazoles and can be subsequently cleaved under acidic conditions yielding substituted α-aminomethyl tetrazoles.
Alexander Doemling, Dömling, Alexander, Barbara Beck, Marina Magnin‐Lachaux, Magnin-Lachaux, Marina, Beck, Barbara   +5 more
core   +1 more source

Consecutive hydrazino-Ugi-azide reactions: synthesis of acylhydrazines bearing 1,5-disubstituted tetrazoles

Beilstein Journal of Organic Chemistry, 2017
Isocyanide-based multicomponent reactions (IMCRs) allow the construction of relatively complex molecules through a one-pot synthesis. The combination of IMCRs in a consecutive or sequential fashion further extends the complexity of the molecules obtained.
Angélica de Fátima S. Barreto, Veronica Alves dos Santos, Carlos Kleber Z. Andrade   +2 more
doaj   +1 more source

Flame‐Retardant Quasi‐Solid‐State Electrolytes From Self‐Assembled Azolate Hybrid Frameworks for Highly Safe Lithium Batteries

Angewandte Chemie, Volume 138, Issue 34, 17 August 2026.
This work develops a spray‐assisted in situ assembly technique to construct AHF materials with nitrogen/oxygen‐regulated one‐dimensional channels on glass fiber, providing abundant active sites and enabling rapid transport for lithium ions. Subsequently, phosphate flame retardants are encapsulated via in situ polymerization, resulting in a thermally ...
Shun Wang, Qimin Zhu, Yuanyuan Tian, Peiyu Cui, Qing Ji, Tian Xie, Hong Wang, Dong Zhou, Guoxiu Wang, Wenhuan Huang   +9 more
wiley   +2 more sources

Synthesis and Biological Evaluation of Well‐Defined M6P(n)‐Modified Glycopeptides for Targeted Protein Degradation

Chemistry – A European Journal, Volume 32, Issue 33, 1 September 2026.
A synthetic methodology has been developed to prepare multifunctional M6P and M6Pn ligands of different valency. The glycopeptides were conjugated to cetuximab and then examined to mediate cellular uptake of fluorescently labeled EGFRvIII. Only cetuximab modified by glycopeptides having 3 or 6 M6P or M6Pn residues demonstrated greater uptake.
Patrycja Lenartowicz, Jan‐Willem H. Langenbach, Nataliia Voloshyna, David Aidukas, Arwin J. Brouwer, John A. W. Kruijtzer, Geert‐Jan Boons   +6 more
wiley   +1 more source