Results 1 to 10 of about 19,065 (226)

Synthesis and Antileishmanial Activity of 1,2,4,5-Tetraoxanes against Leishmania donovani [PDF]

, 2020
A chemically diverse range of novel tetraoxanes was synthesized and evaluated in vitro against intramacrophage amastigote forms of Leishmania donovani. All 15 tested tetraoxanes displayed activity, with IC50 values ranging from 2 to 45 µm.
Amado, Patrícia, Cabral, Lília, Cojean, Sandrine, Cristiano, Maria De Lurdes, Loiseau, Philippe M., Pomel, Sébastien   +5 more
core   +1 more source

In vitro assessment of antimicrobial, antioxidant, and cytotoxic properties of Saccharin-Tetrazolyl and-Thiadiazolyl derivatives: the simple dependence of the pH value on antimicrobial activity [PDF]

, 2019
The antimicrobial, antioxidant, and cytotoxic activities of a series of saccharin-tetrazolyl and -thiadiazolyl analogs were examined. The assessment of the antimicrobial properties of the referred-to molecules was completed through an evaluation of ...
Andrade, Joana M., Cabral, Lília, Cristiano, Maria de Lurdes, Frija, Luís M. T., Ntungwe, Epole, Pombeiro, Armando J. L., Rijo, Patrícia, Sitarek, Przemysław, Toma, Monika, Śliwiński, Tomasz   +9 more
core   +1 more source

Hexaaquazinc(II) dinitrate bis[5-(pyridinium-3-yl)tetrazol-1-ide] [PDF]

, 2018
Indexación: Scopus.Funding for this research was provided by: Fondecyt Regular (award No. 1151527); Proyecto REDES ETAPA INICIAL, Convocatoria 2017 (award No. REDI170423); Millennium Institute for Research in Optics (MIRO); Basal USA (award No.
Chi-Duran, I., Enriquez, J., Herrera, F., Singh, D.P., Vega, A.   +4 more
core   +1 more source

Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists [PDF]

, 2014
A knowledge-based library of aryl 2,3-dichlorophenylsulfonamides was synthesised and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimisation programme.
Copley, R.C.B., Miah, A.H., O'Flynn, D., Percy, J.M., Procopiou, P.A.   +4 more
core   +1 more source

Computationally motivated synthesis and enzyme kinetic evaluation of N-(β-d-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors [PDF]

, 2015
Following our recent study of N-(β-D-glucopyranosyl)-oxadiazole-carboxamides (Polyák et al., Biorg. Med. Chem. 2013, 21, 5738) revealed as moderate inhibitors of glycogen phosphorylase (GP), in silico docking calculations using Glide have been performed ...
Alex, Arunan, Benltifa, Bokor, Broggini, Brownlee, Carta, Cheng, Cho, Chrysina, Condi, Danaei, Docsa, Fischer, Francl, Friesner, Hayes, Hayes, Hehre, Huisgen, Huisgen, Huisgen, Jorgensen, Jorgensen, Kaminski, Kantsadi, Kantsadi, Kenny, Koldobskii, Kun, Lagorce, Lipinski, Lonsdale, Marten, Murray, Murray, Nagy, Nagy, Oikonomakos, Paolini, Polya, Polyák, Pospisil, Potts, Potts, Smith, Somsák, Somsák, Somsák, Somsák, Still, Tannor, Veber, Woon, Zhao, Zhong, Zhou, Ősz   +57 more
core   +1 more source

Chemical investigation of light induced DNA bipyrimidine damage and repair [PDF]

, 2011
In all organisms, genetic information is stored in DNA and RNA. Both of these macromolecules are damaged by many exogenous and endogenous events, with UV irradiation being one of the major sources of damage.
Carell, Thomas, Heil, Korbinian, Pearson, David   +2 more
core   +1 more source

Indium-Mediated Cleavage of the Trityl Group from Protected 1H-Tetrazoles [PDF]

, 2015
On treatment with indium metal in MeOH–THF, trityl groups undergo reductive removal from 1H-protected tetrazoles (including aliphatic, aromatic, and heteroaromatic substituents), affording the corresponding free tetrazoles in excellent yields, without ...
Behloul, Cherif, Bouchelouche, Kenza, Foubelo, Francisco, Guijarro, David, Nájera, Carmen, Yus, Miguel   +5 more
core   +2 more sources

Long-range 1H-15N J couplings providing a method for direct studies of the structure and azide-tetrazole equilibrium in a series of azido-1,2,4-triazines and azidopyrimidines [PDF]

, 2013
The selectively 15N labeled azido-1,2,4-triazine 2*A and azidopyrimidine 4*A were synthesized by treating hydrazinoazines with 15N-labeled nitrous acid.
Arseniev, A. S., Chupakhin, O. N., Deev, S. L., Khalymbadzha, I. A., Rusinov, V. L., Shenkarev, Z. O., Shestakova, T. S.   +6 more
core   +1 more source

Photochemical Transformations of Tetrazole Derivatives: Applications in Organic Synthesis [PDF]

, 2010
Tetrazoles remain a challenge to photochemists. Photolysis leads to cleavage of the tetrazolyl ring, may involve various photodegradation pathways and may produce a diversity of photoproducts, depending on the structure and conformational flexibility of
Amin Ismael, Araujo, Brigas, Butler, Butler, Catalan, Cristiano, Elguero, Gómez-Zavaglia, Gómez-Zavaglia, Katritzky, Koldobskii, Koldobskii, Luís Miguel Teodoro Frija, Maier, Maria Lurdes Santos Cristiano, Moore, Ostrovskii, Ostrovskii   +18 more
core   +2 more sources

Iridium-catalysed ortho-H/D and -H/T exchange under basic conditions : C-H activation of unprotected tetrazoles [PDF]

, 2016
The first examples of selective ortho-directed C-H activation with unprotected 2-aryltetrazoles are described. A new base-assisted protocol for iridium (I) hydrogen isotope exchange catalysis allows access to ortho-deuterated and tritiated tetrazoles ...
Atzrodt, Jens, Derdau, Volker, Kerr, William J., Lindsay, David M., Reid, Marc, Rojahn, Patrick, Weck, Remo   +6 more
core   +1 more source