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Imidazole: Synthesis, Functionalization and Physicochemical Properties of a Privileged Structure in Medicinal Chemistry

open access: yesMolecules, 2023
Imidazole was first synthesized by Heinrich Debus in 1858 and was obtained by the reaction of glyoxal and formaldehyde in ammonia, initially called glyoxaline.
CARLOS Alberto Manssour Fraga   +1 more
exaly   +3 more sources

Imidazole Hybrids: A Privileged Class of Heterocycles in Medicinal Chemistry with New Insights into Anticancer Activity

open access: yesMolecules
Imidazole is a five-membered heterocyclic system featuring two nitrogen heteroatoms at the 1- and 3-positions of the ring. The imidazole scaffold is particularly suited for kinase inhibition concepts.
Khurshed Bozorov   +2 more
exaly   +3 more sources

Structural Studies and Investigation on the Activity of Imidazole-Derived Thiosemicarbazones and Hydrazones against Crop-Related Fungi

open access: yesMolecules, 2013
New imidazole derived thiosemicarbazones and hydrazones were prepared by condensation of 4(5)-imidazole carboxaldehyde, 4-(1H-imidazole-1-yl)benzaldehyde and 4-(1H-imidazole-1-yl)acetophenone with a thiosemicarbazide or hydrazide.
Heloisa Beraldo   +2 more
exaly   +3 more sources

Cholinesterase-like organocatalysis by imidazole and imidazole-bearing molecules [PDF]

open access: yesScientific Reports, 2017
AbstractOrganocatalysis, which is mostly explored for its new potential industrial applications, also represents a chemical event involved in endogenous processes. In the present study, we provide the first evidence that imidazole and imidazole derivatives have cholinesterase-like properties since they can accelerate the hydrolysis of acetylthiocholine
NIERI, PAOLA   +5 more
openaire   +6 more sources

Imidazole-Dependent Assembly of Copper Polymolybdate Frameworks for One-Pot Sulfide Oxidation and C–H Activation [PDF]

open access: yes, 2022
With the arising concern of environmental problems, the removal of polycyclic aromatic hydrocarbons or sulfides in fuel oils is an indispensable process to achieve a clean energy source.
Junyu Ren (7289774)   +9 more
core   +9 more sources

Imidazole-Functionalized Imide Interlayers for High Performance Organic Solar Cells [PDF]

open access: yes, 2021
Imidazole-functionalized naphthalene diimide and perylene diimide were efficiently synthesized at low cost and used as versatile cathode interlayers in organic solar cells.
Yufeng Jiang   +13 more
core   +1 more source

Imidazoles as Potential Anticancer Agents: An Update on Recent Studies

open access: yesMolecules, 2021
Nitrogen-containing heterocyclic rings are common structural components of marketed drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide range of bioactive compounds.
Pankaj Sharma   +4 more
doaj   +1 more source

Acid Dissociation Constants of the Benzimidazole Unit in the Polybenzimidazole Chain: Configuration Effects

open access: yesMolecules, 2022
The acid dissociation constant of three benzimidazoles, namely 2,2′-bibenzo[d]imidazole, 2,5′-bibenzo[d]imidazole, and 5,5′-bibenzo[d]imidazole, have been investigated by means of density functional theory calculations in gas phase and in aqueous ...
Liudmil Antonov   +2 more
doaj   +1 more source

Review of pharmacological effects of imidazole derivatives [PDF]

open access: yesĶazaķstannyṇ Klinikalyķ Medicinasy, 2022
Imidazole derivatives are the perspective class of drugs with a broad spectrum of application in medicine. Imidazole is a nitrogen-containing heterocyclic ring; it has two equivalent forms; hydrogen atom may be located on any of two nitrogen atoms ...
Daniya Serdaliyeva   +5 more
doaj   +1 more source

Study on tri-imidazole derivatives modified with triazine-trione structure as latent curing agents for epoxy resin

open access: yesSN Applied Sciences, 2021
In this paper, four novel kinds of triazine-trione based tri-imidazole derivatives (IM-TT, 2MI-TT, 2EI-TT and EMI-TT) were synthesized through the addition reaction between triglycidyl isocyanurate (TGIC) and imidazole (IM), 2-methylimidazole (2MI), 2 ...
Xiaodong Wan   +3 more
doaj   +1 more source

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