Results 41 to 50 of about 184,143 (305)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
4-Phenyl-1H-imidazole (a low-temperature redetermination), 1-benzyl-1H-imidazole and 1-mesityl-1H-imidazole [PDF]
, 2004 Low-temperature studies of the simple variously substituted imidazole types 4-phenyl-1H-imidazole, C9H8N2, 1-benzyl-1H-imidazole, C10H10N2, and 1-mesityl-1H-imidazole, C12H14N2, extend comparisons between parent imidazole species and their derivatives ...
Nielsen, DJ (15490025) +3 more
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Case Studies in Chemical and Environmental EngineeringA natural amino acid methionine-derived imidazole zwitterion was synthesized and investigated as a corrosion inhibitor on cold-rolled steel in an acid environment using weight loss, electrochemistry, and SEM techniques.
Wan Mohd Norsani Wan Nik +7 more
doaj +1 more source
Metabolism of Imidazole by a Pseudomonad [PDF]
Journal of Bacteriology, 1971 Intermediates formed during the microbial degradation of imidazole, namely 4(5)-imidazolone, formiminoglycine, and possibly glycine, are similar to those formed during metabolism of imidazole derivatives.
H G, Oien, L D, Wright
openaire +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
2′-Chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine
Molbank, 2018 The compound 2′-chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine was obtained with a good yield by the reaction of 2-chloro-4-(1-methyl-1H-imidazol-2-yl)pyridine with (2-chloropyridin-4-yl)boronic acid and structurally characterized by nuclear ...
Dhafer Saber Zinad +2 more
doaj +1 more source
Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes
Pharmaceutics, 2023 The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily
Shu-Rui Li +3 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
IMIDAZOLE-BASED MOLECULES AS PREVENTATIVE THERAPEUTICS FOR ISCHEMIC NEURONAL DEGRADATION [PDF]
, 2013 Computer-aided drug design is an exceptionally useful tool for screening a large number of potential drug molecules to evaluate their therapeutic potential. This technique is both effective and economical.
O'Neill, Kale
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source