Results 31 to 40 of about 193,713 (301)
Synthesis, Characterization and Biological Evaluation of Novel Tetrasubsituted Imidazole Compounds [PDF]
, 2020 A new class of tetrasubsituted imidazole based compounds were synthesized using multicomponent one pot synthesis scheme through cyclocondensation reaction of benzil, aromatic primary amines, aldehydes and ammonium acetate in glacial acetic acid.
khurram, shahzad +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Case Studies in Chemical and Environmental EngineeringA natural amino acid methionine-derived imidazole zwitterion was synthesized and investigated as a corrosion inhibitor on cold-rolled steel in an acid environment using weight loss, electrochemistry, and SEM techniques.
Wan Mohd Norsani Wan Nik +7 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
2′-Chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine
Molbank, 2018 The compound 2′-chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine was obtained with a good yield by the reaction of 2-chloro-4-(1-methyl-1H-imidazol-2-yl)pyridine with (2-chloropyridin-4-yl)boronic acid and structurally characterized by nuclear ...
Dhafer Saber Zinad +2 more
doaj +1 more source
, 2018 Phosphate diester hydrolysis is strongly accelerated, by a factor of 104, in the presence of artificial enzymes especially designed in the light of spatiotemporal concepts, anchoring imidazoles in a pillar[5]arene matrix. Host:guest complexes cleave the
Eduardo H. Wanderlind (4975247) +9 more
core +1 more source
, 2023 Imidazole-based compounds form a prominent class of heterocyclic compounds, displaying diverse applications, especially with regards to its biological and pharmacological activities.
M. Arockia doss (13004926) +1 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Synthesis and Biological Evaluation of Novel Imidazole Derivatives as Antimicrobial Agents
BiomoleculesImidazole derivatives are considered potential chemical compounds that could be therapeutically effective against several harmful pathogenic microbes.
Huda A. Al-Ghamdi +8 more
doaj +1 more source