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Imidazole Hybrids: A Privileged Class of Heterocycles in Medicinal Chemistry with New Insights into Anticancer Activity

Molecules
Imidazole is a five-membered heterocyclic system featuring two nitrogen heteroatoms at the 1- and 3-positions of the ring. The imidazole scaffold is particularly suited for kinase inhibition concepts.
Zarifa Murtazaeva, Azizbek Nasrullaev, Anvarjon Buronov, Shukhrat Gaybullaev, Lifei Nie, Sodik Numonov, Zohidjon Khushnazarov, Davron Turgunov, Rustamkhon Kuryazov, Jiangyu Zhao, Khurshed Bozorov   +10 more
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Synthesis and crystal structures of two 1,3-di(alkyloxy)-2-(methylsulfanyl)imidazolium tetrafluoridoborates

Acta Crystallographica Section E: Crystallographic Communications, 2020
Two salts were prepared by methylation of the respective imidazoline-2-thione at the sulfur atom, using Meerwein's salt (trimethyloxonium tetrafluoridoborate) in CH2Cl2. 1,3-Dimethoxy-2-(methylsulfanyl)imidazolium tetrafluoridoborate (1), C6H11N2O2S+·BF4−
Thomas Gelbrich, Martin Lampl, Gerhard Laus, Volker Kahlenberg, Hubert Huppertz, Herwig Schottenberger   +5 more
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Homoleptic imidazolate frameworks (3)(infinity)[Sr1-xEux(Im)(2)]-hybrid materials with efficient and tuneable luminescence. [PDF]

, 2011
Homoleptic frameworks of the formula 3∞[Sr1−xEux(Im)2] (1) x = 0.01–1.0; Im− = imidazolate anion, C3H3N2−) are hybrid materials that exhibit an intensive green luminescence.
Abergel, Alcock, Alexander Zurawski, Allendorf, Althues, Bauer, Binnemans, Biradha, Blake, Blasse, Büchner, Carlos, Chen, Claus Feldmann, de Lill, De Silva, Deacon, Dominik Baumann, Eberhardt, Eddaoudi, Eddaoudi, Ferey, Ferey, Giraud, Gándara, Huang, Hunter, Höller, Janiak, Janiak, Juza, Kim, Kitagawa, Klaus Müller-Buschbaum, Kuroda, Lan, Lia, Liu, Long, Marit Mai, Mueller, Mueller-Mach, Müller-Buschbaum, Müller-Buschbaum, Müller-Buschbaum, Müller-Buschbaum, Müller-Buschbaum, Müller-Buschbaum, O'Keefe, Pan, Park, Quitmann, Schmidt, Seo, Serre, Shannon, Shionoya, Stylianou, Voloshin, Wang, Yaghi, Yang, Zhang, Zhang   +63 more
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Imidazole: Having Versatile Biological Activities

Journal of Chemistry, 2013
Imidazoles have occupied a unique position in heterocyclic chemistry, and its derivatives have attracted considerable interests in recent years for their versatile properties in chemistry and pharmacology.
Amita Verma, Sunil Joshi, Deepika Singh
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Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles [PDF]

, 2018
Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/
Andrades-Lagos, J., Campanini-Salinas, J., Lorca, M., Mella, J., Morales-Verdejo, C., Recabarren-Gajardo, G., Soto-Delgado, J., Vásquez-Velásquez, D.   +7 more
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Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. [PDF]

, 2013
The antitumor prodrug Temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (EC 2.1.1.63, MGMT). Tumor
Arris C. E., Arrowsmith J., Barvaux V. A., Boberg F., Boyd M. R., Bunz F., Damera K., Darkes M. J. M., De K., Denny B. J., Dimitrios Pletsas, Dinca E. B., Elrashied A. E. Garelnabi, Garelnabi E. A. E., Hirose Y., Honnalli S. S., Judson P. L., Karran P., Karran P., Kotera M., Leteurtre F., Li Li, Liu L., McElhinney R. S., McGarrity J. F., Mladek A. C., Nishizuka S., Pletsas D., Richard T. Wheelhouse, Roger M. Phillips, Sarkaria J. N., Schmidt B. F., Schmiedekamp A., Shealy Y. F., Siddiqui A. A., Smith R. H., Stevens M. F. G., Svilar D., Wang Y., Wheelhouse R. T., Wheelhouse R. T., Zhang J., Zhang J.   +42 more
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Amino acid-derived imidazole zwitterion as green interfacial corrosion inhibitor for cold rolled steel

Case Studies in Chemical and Environmental Engineering
A natural amino acid methionine-derived imidazole zwitterion was synthesized and investigated as a corrosion inhibitor on cold-rolled steel in an acid environment using weight loss, electrochemistry, and SEM techniques.
Wan Mohd Norsani Wan Nik, Jiyaul Haque, Mohd Sabri Mohd Ghazali, Atria Pradityana, Izionworu Vincent Onuegbu, Walid Daoudi, Elyor Berdimurodov, Ahmed Abdulamier Al-Amiery   +7 more
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2′-Chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine

Molbank, 2018
The compound 2′-chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine was obtained with a good yield by the reaction of 2-chloro-4-(1-methyl-1H-imidazol-2-yl)pyridine with (2-chloropyridin-4-yl)boronic acid and structurally characterized by nuclear ...
Dhafer Saber Zinad, Dunya L. AL-Duhaidahaw, Ahmed Al-Amiery   +2 more
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Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Pharmaceutics, 2023
The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily
Shu-Rui Li, Yi-Min Tan, Ling Zhang, Cheng-He Zhou   +3 more
doaj   +1 more source

The identification of histidine ligands to cytochrome a in cytochrome c oxidase [PDF]

, 1985
A histidine auxotroph of Saccharomyces cerevisiae has been used to metabolically incorporate [1,3-15N2] histidine into yeast cytochrome c oxidase. Electron nuclear double resonance (ENDOR) spectroscopy of cytochrome a in the [15N]histidine-substituted ...
Chan, Sunney I., Martin, Craig T., Scholes, Charles P.   +2 more
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