Results 51 to 60 of about 196,937 (296)

New Imidazole-Based N-Phenylbenzamide Derivatives as Potential Anticancer Agents: Key Computational Insights

Frontiers in Chemistry, 2022
An efficient atom-economical synthetic protocol to access new imidazole-based N-phenylbenzamide derivatives is described. A one-pot three-component reaction was utilized to provide a series of N-phenylbenzamide derivatives in a short reaction time (2–4 h)
M. Shaheer Malik, Reem I. Alsantali, Qazi Mohammad Sajid Jamal, Zaki S. Seddigi, Moataz Morad, Meshari A. Alsharif, Essam M. Hussein, Essam M. Hussein, Rabab S. Jassas, Munirah M. Al-Rooqi, Zainularifeen Abduljaleel, Ahmed O. Babalgith, Hatem M. Altass, Ziad Moussa, Saleh A. Ahmed, Saleh A. Ahmed   +15 more
doaj   +1 more source

Imidazole-Functionalized Y‑Shaped Push–Pull Dye for Nerve Agent Sensing as well as a Catalyst for Their Detoxification

A Y-shaped push–pull dye (1) with N,N-dimethylanilino donors and a benzonitrile acceptor connected via an imidazole-based π-conjugated spacer was designed. It showed a dark yellow color in solution due to facile intramolecular charge-transfer interaction,
Nilanjan Dey (1913116), Filip Bureš (1405753), Jiří Kulhánek (6298601), Santanu Bhattacharya (156609)   +3 more
core   +2 more sources

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Stepwise Fusion of Porphyrin β,β′-Pyrrolic Positions to Imidazole Rings

, 2016
A strategy for the stepwise annulation of pyrrolic rings of a porphyrin to imidazole rings is presented. Mono(imidazole), Janus and corner bis(imidazole), T-shaped tris(imidazole), and tetrakis(imidazole) porphyrins have been synthesized and ...
Sébastien Richeter (1660486), Mamadou Lo (2191501), Jean-François Lefebvre (2191504), Arie van der Lee (1512520), Dominique Leclercq (2191507)   +4 more
core   +3 more sources

Crystal structure of 1-[(1-methyl-5-nitro-1H-imidazol-2-yl)methyl]pyridinium iodide

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title salt, C10H11N4O2+·I−, the asymmetric unit consists of a pyridinium cation bearning a (1-methyl-5-nitro-1H-imidazol-2-yl)methyl group at the N position and an iodide anion.
Roumaissa Belguedj, Abdelmalek Bouraiou, Hocine Merazig, Ali Belfaitah, Sofiane Bouacida   +4 more
doaj   +1 more source

1-Propyl-4(5)-Methylimidazole Isomers for Temperature Swing Solvent Extraction

Molecules, 2022
Temperature swing solvent extraction (TSSE) utilizes an amine solvent with temperature-dependent water solubility to dissolve water at a lower temperature to concentrate or crystallize the brine and the phases are separated.
Shuai Qian, Lauren M. Ward, Luke S. Rakers, Steven T. Weinman, Jason E. Bara   +4 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Synthesis and Characterization of Some New 4-Methyl-5-Imidazole Carbaldehyde Derivatives

Journal of the Turkish Chemical Society, Section A: Chemistry, 2019
Imidazole is a common and important heterocyclic fragment of many biologically important molecules. 5-imidazole-carbaldehydes containing mono- (N-1) methyl (or aryl) analogs are commonly used as building blocks in medical chemistry.
Ersin Orhan , Mahmut Köse, Demet Alkan, Leyla Öztürk   +3 more
doaj  

Computational Modelling of Imidazole Protection of Coordinated Gadolinium Tetraphenylporphyrine Against Molecular Oxygen Attack

Molecules
Promising photophysical properties and the enhanced sensitivity to molecular oxygen of porphyrins metalated with Gd(III) generate a need for their detailed description on an atomic level with the account of coordinated ligands, which also influence the ...
Vladimir Pomogaev, Daniil Lukyanov, Elena Solovyeva   +2 more
doaj   +1 more source