Results 31 to 40 of about 19,065 (226)

New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum [PDF]

, 2018
Background: The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs.
A Gómez-Zavaglia, A Ismael, A Ismael, A Paulo, A Siriwardana, AM Dondorp, AM Dondorp, António Sebastião Rodrigues, B Weniger, B Witkowski, B Witkowski, Bruno Guerreiro, C Amaratunga, C Amaratunga, D Ménard, EA Ashley, ES Schaffert, F Ariey, F Nogueira, F Teuscher, Fatima Nogueira, FG Baptista, H Noedl, H Noedl, H Singh, HM Ismail, I Fernández, J Adamec, J Jourdan, J Straimer, J Straimer, J Straimer, J Straimer, JL Vennerstrom, K Chauhan, K Chauhan, K Chotivanich, KM Tun, L Lobo, LH Carvalho, Lis Lobo, Lília I. L. Cabral, M Drąg-Zalesińska, M Machado, M Mota, M Tukulula, MA Fügi, Maria Inês Sena, Maria L. S. Cristiano, MD Spring, N Thuy-Nhien, NCP Araújo, PB Mohite, PM O’Neill, PN Soh, RJ Herr, RS Upadhayaya, S Arulmurugan, S Chaorattanakawee, S Nwaka, S Takala-Harrison, S Takala-Harrison, SA Santos, SD Fontaine, T Yang, TNC Wells, Valter Ferreira de Andrade-Neto, VS de Sena Pereira, W Peters, WA Kite, World Health Organization, X Fan, Y Lubell, Y Tang, Z Li, Z Wang   +75 more
core   +2 more sources

Theoretical Studies on Mild Steel Corrosion Inhibition by 5-Substituted 1H-Tetrazoles in Acidic Media

International Journal of Electrochemical Science, 2019
In this theoretical study, calculations for the three types of the tetrazole which are 2-(1H-Tetrazole-5-yl)-3-phenylacrylonitrile, 2-(1H-Tetrazole-5-yl)-3-(4-nitrophenylacrylonitrile), and 2-(1H-Tetrazole-5-yl)-3-(4- hydroxyphenyl acrylonitrile) showing
Mahmud Ibrahim Elusta, Murat Alper Başaran, Fatma Kandemirli   +2 more
doaj   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

Crystal structure of methyl 2-[5-(2-hydroxyphenyl)-2H-tetrazol-2-yl]acetate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title compound, C10H10N4O3, was synthesized by the esterification of hydroxyphenyl tetrazole. There is an intramolecular O—H...N hydrogen bond present involving the hydroxy group and the tetrazole ring.
Seul Gi Lee, Ji Yeon Ryu, Junseong Lee
doaj   +1 more source

X-Ray, IR, NMR, UV-visible spectra and DFT analysis of 5-aryloxy-(1H)-tetrazoles, structure, conformation and tautomerism [PDF]

, 2014
The predominant tautomeric forms of N1–H, N2–H of 5-(2,6-dimethyl- and 5-(2,6-diisopropylphenoxy)-(1H)-tetrazoles were analyzed at B3LYP method using 6-311G(d,p) basis set in the gas phase.
Alireza Dadrass, Ertan Şahin, Jannet Soleimannejad, Mohamed I. Mohamed Tahir, Mohammad Samim Enayati, Nader Noroozi Pesyan, Narges Ostadhosseini, Sadeghali Bavafa, Sajedin Hoseinpour   +8 more
core   +1 more source

2-Methyl-3-{4-[2-(1H-tetrazol-5-yl)ethylamino]phenyl}-3H-quinazolin-4-one

Molbank, 2010
This present work aims at synthesizing a novel tetrazole from quinazolinone. 3-(4-Aminophenyl)-2-methyl-3H-quinazolin-4-one is converted into a nitrile by reacting it with acrylonitrile and triton B.
Helen P. Kavitha, Subramaniyan Arulmurugan   +1 more
doaj   +1 more source

Regiospecific synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles via photochemically generated nitrile imine intermediates [PDF]

, 2014
The synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles was achieved under photochemical conditions. This simple and mild one-step reaction provides regiospecific access to 2,4,5-substituted 1,2,3-triazoles via a nitrile imine ...
Harris, Robert, Jamieson, Craig, Stewart, Sam   +2 more
core   +1 more source

Síntese e modificações de derivados heterocíclicos de D-arabinose: potenciais inibidores de glicose-6-fosfato isomerase e de glicosamina-6-fosfato sintase Synthesis and modifications of heterocyclic derivatives of D-arabinose: potential inhibitors of glucose-6-phosphate isomerase and glucosamine-6-phosphate synthase

Química Nova, 2008
The synthesis of -5-(D-arabino-1,2,3,4-tetrahydroxybutyl)tetrazole and -2-(D-arabino-1,2,3,4-tetra-acetoxybutyl)-5-methyl-1,3,4-oxadiazole from D-arabinose is described.
Renato Márcio Ribeiro Viana, Maria Auxiliadora Fontes Prado, Ricardo José Alves   +2 more
doaj   +1 more source

New ecofriendly heterogeneous nano-catalyst for the synthesis of 1-substituted and 5-substituted 1H-tetrazole derivatives

Scientific Reports, 2022
A novel ecofriendly heterogeneous catalyst containing Schiff base coordinated Cu(II) covalently attached to Fe3O4@SiO2 nanoparticles through imidazolium linker [Fe3O4@SiO2-Im(Br)-SB-Cu (II)] was synthesized and characterized by using various techniques ...
Mahboobeh-Sadat Mashhoori, Reza Sandaroos   +1 more
doaj   +1 more source

Nitrene-carbene-carbene rearrangement. photolysis and thermolysis of tetrazolo[5,1- a ]phthalazine with formation of 1-phthalazinylnitrene, o-cyanophenylcarbene, and phenylcyanocarbene [PDF]

, 2013
1-Azidophthalazine 9A is generated in trace amount by mild FVT of tetrazolo[5,1-a]phthalazine 9T and is observable by its absorption at 2121 cm-1 in the Ar matrix IR spectrum.
Hoj, Martin, Kvaskoff, David, Wentrup, Curt   +2 more
core   +1 more source