Results 91 to 100 of about 5,897 (227)
Nature Communications, 2019 Asymmetric isocyanide-based multicomponent reactions are elegant, yet challenging, strategies to access valuable N-heterocycles. Here, the authors employ a chiral Mg(II) -N,N′-dioxide catalyst in three- or four-component reactions to obtain chiral ...
Qian Xiong +4 more
doaj +1 more source
Molecules, 2015 A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%–95%) or ...
Luís E. Cárdenas-Galindo +4 more
doaj +1 more source
Structure‐Guided Optimization of a Molecular Glue Targeting the KBTBD4‐HDAC1/2 Complex
ChemMedChem, Volume 21, Issue 16, 27 August 2026.Structure‐based optimization of the molecular glue degrader UM171 resulted in a near 20‐fold improvement of ternary complex stability but also revealed the challenges of glue discovery. Optimization of UM171, a molecular glue initiating the degradation of neosubstrate HDAC1/2–CoREST–LSD1 through a multiprotein complex formed with KBTBD4, was carried ...
Timea Balo +8 more
wiley +1 more source
Tetrazolium Compounds: Synthesis and Applications in Medicine
Molecules, 2015 Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range
Cheng-Xi Wei, Ming Bian, Guo-Hua Gong
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ChemMedChem, Volume 21, Issue 16, 27 August 2026.ST6GAL1 sialylates glycoconjugates in the Golgi, modulating immune recognition and enabling tumor immune evasion. To effectively reach ST6GAL1, inhibitors should demonstrate good membrane permeability. Based on nonpermeable hit JFD 00458, we developed sulfonylurea analogs achieving increased membrane permeability and potency.
Natan Koraj +9 more
wiley +1 more source
Polymethylenetetrazole: Synthesis, Characterization, and Energetic Properties
MoleculesThe tetrazole moiety remains one of the most interesting scaffolds in the development of new high-energy density materials (HEDMs) because of its desired characteristics, such as high nitrogen content and heat of formation (HOF).
Ljubica Brenjo +6 more
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Synthesis and oxidative coupling of 1,5-disubstituted tetrazoles
, 2013 Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Zuzana Rania Hrušková Supervisor: Prof. RNDr.
Hrušková, Zuzana Rania
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Catalyst‐Free Cyanation of Arenes by Acetonitrile in a Plasma–Liquid Microreactor
Chemistry – A European Journal, Volume 32, Issue 32, 24 August 2026.An original approach of arylnitrile synthesis was developed by generating an argon plasma in contact with solutions of arene in acetonitrile within a gas‐liquid microreactor. Plasma activation of acetonitrile generated cyano radicals, enabling a catalyst‐free C‐H cyanation of arenes.
Pierre Dedieu +4 more
wiley +1 more source
CHIMIA, 2007 This mini-review concerns the broad application of (S)- and (R)-5-pyrrolidin-2-yl-1H-tetrazoles as organocatalysts. A summary of methods for their synthesis is followed by a discussion of the general reaction mechanism and subsequent analysis of
Deborah A. Longbottom +2 more
doaj +1 more source
Direct Activation of the C-H Bond in Tetrazoles
, 2010 Direct activation of C-H bond in tetrazoles Richard Lubojacký, 5th grade Supervisor: Prof. RNDr. Milan Pour, Ph.D. Department of Inorganic and Organic Chemistry, Faculty of Pharmacy in Hradec Králové Within the framework of this diploma thesis, direct ...
Lubojacký, Richard
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