Results 31 to 40 of about 6,074 (218)

Tetrazole containing 1,5-benzothiazepines: Design, synthesis, in silico and in vitro evaluation as medicinally potent ACE inhibitors [PDF]

Journal of Chemistry Letters
It is reported in literature that the key role of Angiotensin-I Converting Enzyme (ACE) is to convert angiotensin-I (Ang-I) to angiotensin-II (Ang-II) and to degrade bradykinin (BK) into the inactive metabolites.
Bhawani Singh, Ashok Suman
doaj   +1 more source

3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1H-Tetrazol-5-yl)-β-Carbolines: Synthesis and Evaluation as Anticancer Agents

Pharmaceuticals, 2022
Herein, the synthesis and anticancer activity evaluation of a series of novel β-carbolines is reported. The reactivity of nitrosoalkenes towards indole was explored for the synthesis of novel tryptophan analogs where the carboxylic acid was replaced by a
João L. P. Ribeiro, Joana B. Loureiro, Susana M. M. Lopes, Lucília Saraiva, Teresa M. V. D. Pinho e Melo   +4 more
doaj   +1 more source

Probing Polar‐π Interactions Between Tetrazoles and Aromatic Rings** [PDF]

, 2023
The heterocyclic tetrazole, a well-established bioisosteric replacement of carboxylic acid, plays an important role in medicinal chemistry. To deepen the functional understanding of tetrazoles in chemical sciences, it is essential to investigate the ...
Jie Jian, Jasmin Mecinović, Bickelhaupt, F. Matthias, Jordi Poater, Paul Tinnemans, Jian, Jie, Tinnemans, Paul, Roel Hammink, Bickelhaupt, F Matthias, F. Matthias Bickelhaupt, Hammink, Roel, Poater, Jordi, Mecinović, Jasmin; id_orcid, Mecinovic, J, Bickelhaupt, F.M., Jian, J., Tinnemans, P., Hammink, R., Mecinovic, Jasmin   +18 more
core   +1 more source

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Crystal structure of poly[di-μ-aqua-{5-[(1Z)-2-(4-chlorophenyl)-1-cyanoethenyl]-1,2,3,4-tetrazol-1-ido-κN1}sodium]

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, [Na(C10H5ClN5)(H2O)2]n, infinite chains of [Na(H2O)2]+ cations having a diamond-shaped cross-section and running parallel to the b axis are formed.
Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Ahmed M. M. El-Saghier, Mustafa R. Albayati   +4 more
doaj   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Concise Synthesis of Tetrazole Macrocycle [PDF]

Organic Letters, 2017
A concise two step synthesis of tetrazole containing macrocycles from readily accessible starting materials is presented. The first step comprises a chemoselective amidation of amino acid derived isocyanocarboxylicacid esters with unprotected symmetrical diamines to afford diverse α-isocyano-ω-amines. In the second step, the α-isocyano-ω-amines undergo
Abdelraheem, Eman M. M.; de Haan, Michel P.; Patil, Pravin; Kurpiewska, Katarzyna; Kalinowska-Tluscik, Justyna; Shaabani, Shabnam; Domling, Alexander   +7 more
openaire   +4 more sources

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Macrocyclization of ω‐Isocyano Aldehydes

Angewandte Chemie, EarlyView.
The ω‐isocyano aldehydes readily undergo cyclization to afford α‐acyloxy, α‐hydroxy, α‐acetamido, and α‐keto macrolactams, as well as tetrazole‐fused macrocycles, via C(sp3)─C(sp2) bond formation, providing access to diverse α‐functionalized medium‐sized lactams and macrolactams. ABSTRACT Medium‐sized rings and macrocycles constitute a privileged class
Baochao Yang, Teerawat Songsichan, Cyril Piemontesi, Qian Wang, Jieping Zhu   +4 more
wiley   +2 more sources

Coupling ofN-tosylhydrazones with tetrazoles : synthesis of 2-β-d-glycopyranosylmethyl-5-substituted-2H-tetrazole type glycomimetics

, 2021
Coupling reactions ofO-peracylated 2,6-anhydro-aldose tosylhydrazones (C-(β-d-glycopyranosyl)formaldehyde tosylhydrazones) with tetrazoles were studied under metal-free conditions using thermic or microwave activation in the presence of different bases ...
Cservenyák, Ivett, Kulcsár, Andrea E., Nilsson, Ulf J., Somsák, László, Kaszás, Tímea, Juhász-Tóth, Éva, Granatino, Paola, Tóth, Marietta, Juhász-Tóth, Éva,, Nilsson, Ulf J.,, Cservenyák, Ivett,, Tóth, Marietta,, Somsák, László,, Kulcsár, Andrea E.,, Kaszás, Tímea,, Granatino, Paola,, Lund University., Paola Granatino, László Somsák, Éva Juhász-Tóth, Ulf J. Nilsson, Andrea E. Kulcsár, Ivett Cservenyák, Marietta Tóth, Tímea Kaszás   +24 more
core   +1 more source