Results 31 to 40 of about 5,247 (179)

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

Síntesis de tetrazoles a partir de aldononitrilos benzoilados [PDF]

, 1978
En este trabajo se realizó, una revisión de los métodos de sintesis de compuestos heterociclicos nitrogenados, obtenidos a partir de hidratos de carbono, en los cuales uno o más átomos del azúcar se incorporan al sistema heterociclico.
Marzoa, Oscar Guillermo
core   +1 more source

Synthesis of tetrazoles as anticuberculotics [PDF]

, 2014
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Petr Vicherek Supervisor: RNDr. Patrik Čonka, Ph.D. Title of diploma thesis: Synthesis of tetrazoles as antituberculotics Although
Vicherek, Petr
core  

Hunting Structural Demons in Digital Reticular Chemistry: Lessons From Metal‐Organic Frameworks

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Digital reticular chemistry is haunted by “structural demons”, chemically invalid models lurking within massive experimental and hypothetical MOF databases. This mini‐review tracks where these anomalies enter the data pipeline, evaluate the modern computational arsenal used to detect them (from rule‐based algorithms to machine‐learning classifiers ...
Yongchul G. Chung, Myoung Soo Lah
wiley   +1 more source

1,1‐and 1,2‐Diborylalkenes: Preparation and Synthetic Applications

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
In this review, we highlight recent advances in the synthesis and reactivity of 1,1‐diborylalkenes and 1,2‐diborylalkenes, along with various transformations leading to C‐C, C‐heteroatom, and multicomponent products. By providing a comprehensive and practical resource, this review aims to assist researchers in exploring the synthetic utility of 1,1 and
Jayaram Vankudoth, Maruti Mali, Fabienne Berrée   +2 more
wiley   +1 more source

Tetrazoles of manno- and rhamno-pyranoses: Contrasting inhibition of mannosidases by [4.3.0] but of rhamnosidase by [3.3.0] bicyclic tetrazoles

, 1999
The synthesis of tetrazoles derived from D-manno and D- rhamnopyranose from L-gulonolactone and of L-rhamnopyranose from D-gulonolactone is described. These and other materials are assessed as inhibitors of glycosidases. The [4.3.0] tetrazoles of D-manno-
Hackett, L, Fleet, George, Smith, C, Fleet, GWJ, Nash, RJ, Watson, AA, Davis, BG, Winchester, BG, Davis, Benjamin, Brandstetter, TW, Griffiths, RC   +10 more
core   +1 more source

Light‐Controlled Peptide Self‐Assembly: From Physicochemical Principles to Emerging Biomedical Applications

Aggregate, Volume 7, Issue 6, June 2026.
This review surveys recent advances in light‐controlled peptide self‐assembly for the design of smart soft matter. It summarizes the underlying physicochemical principles, including thermodynamic control for reshaping free‐energy landscapes, and nonequilibrium control to produce kinetically trapped states and dissipative structures.
Lidong Chen, Yanan Cui, Yuxuan Han, Chuqiang Ke, Wendi Jiang, Rui Yu, Lingling Kang, Kai Liu   +7 more
wiley   +1 more source

Synthesis and Functionalization of 5-Substituted Tetrazoles

, 2010
In the last decades, the chemistry of tetrazoles underwent a great expansion, which was closely connected with their usage as an isosteric replacement of carboxylic acid moiety in the molecules of potential or clinically used drugs.
Roh, Jaroslav
core  

Activation of TREK‐1 and TREK‐2 Two‐Pore Domain Potassium Channels by the Kv4 Channel Modulator, NS5806

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT NS5806 is a diaryl‐urea small molecule developed for the treatment of pain and neurological disorders. A potent activator of Kv4.3 potassium channels, it is widely used to study Kv4 channel physiology in excitable cells, including trigeminal neurons.
E. L. Veale, P. M. Matthews, A. M. Rush, E. B. Stevens, A. Mathie   +4 more
wiley   +1 more source

X-ray, IR, NMR, UV-visible spectra and DFT analysis of 5-aryloxy-(1H)-tetrazoles, structure, conformation and tautomerism

, 2014
The predominant tautomeric forms of N1–H, N2–H of 5-(2,6-dimethyl- and 5-(2,6-diisopropylphenoxy)-(1H)-tetrazoles were analyzed at B3LYP method using 6-311G(d,p) basis set in the gas phase.
Pesyan, Nader Noroozi, Mohamed Tahir, Mohamed Ibrahim, Bavafa, Sadeghali, Soleimannejad, Jannet, Enayati, Mohammad Samim, Dadrass, Alireza, Ostadhosseini, Narges, Sahin, Ertan, Hoseinpour, Sajedin   +8 more
core   +1 more source