Results 301 to 310 of about 160,198 (339)

Angiotensin II Receptor Heterogeneity

American Journal of Hypertension, 1991
The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents. One of our earliest indications was the frequent observation of incomplete inhibition of the binding of AII to adrenal cortical membranes.
William F. Herblin, Andrew T. Chiu, Dale E. McCall, Robert J. Ardecky, David J. Carini, John V. Duncia, Lori J. Pease, Pancras C. Wong, Ruth R. Wexler, Alexander L Johnson, Pieter B.M.W.M. Timmermans   +10 more
openaire   +2 more sources

Angiotensin II receptor antagonists

The Lancet, 2000
Blockade of the renin-angiotensin system began as a way of studying the pathogenesis of cardiovascular disease with specific pharmacological probes. Oral activity, achieved by shortening the original peptide structures, transformed the probes into therapeutic agents, the angiotensin-converting enzyme (ACE) inhibitors.
M, Burnier, H R, Brunner
openaire   +4 more sources

Angiotensin II Receptor Subtypes

American Journal of Hypertension, 1992
The octapeptide, angiotensin II (Ang II), the biologically active component of the renin-angiotensin system, elicits its multiple actions through the stimulation of specific surface receptors on various target organs. Although the existence of Ang II receptor subtypes has been suspected for some time, definitive evidence for Ang II receptor ...
P B, Timmermans, A T, Chiu, W F, Herblin, P C, Wong, R D, Smith   +4 more
openaire   +2 more sources

Human Angiotensin II Receptors are Regulated By Angiotensin II

Clinical and Experimental Hypertension. Part A: Theory and Practice, 1988
Specific angiotensin II (ANG II) binding on human platelets in man was measured to examine ANG II receptor regulation in man. Eight normal volunteers received either a high, or a low sodium diet, or a low sodium diet together with the ANG I converting enzyme inhibitor enalapril.
J F, Mann, M, Leidig, E, Ritz
openaire   +2 more sources

ONTOGENY OF ANGIOTENSIN II RECEPTORS

Cell Biology International, 1996
AbstractAside from the well known role of angiotensin II (Ang II) in blood pressure regulation and fluid homeostasis, accumulating evidence suggests that the octapeptide hormone also plays a role in growth and development. There are two major classes of Ang II receptors (AT1and AT2) which mediate Ang II action.
S, Shanmugam, K, Sandberg
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Angiotensin II Receptors in Testes

Endocrinology, 1988
Receptors for angiotensin II (AII) were identified and characterized in testes of rats and several primate species. Autoradiographic analysis of the binding of 125I-labeled [Sar1,Ile8]AII to rat, rhesus monkey, cebus monkey, and human testicular slide-mounted frozen sections indicated specific binding to Leydig cells in the interstitium.
M A, Millan, G, Aguilera
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Angiotensin II Receptor Assays

Current Protocols in Pharmacology, 1998
AbstractThis unit describes the use of an isolated rabbit thoracic aorta preparation for determining the nature, potency, and selectivity of antagonists to the agonism of angiotensin II at AT1 receptors by measuring their effects on the tension of the tissue.
openaire   +2 more sources

Dihydropyrimidine angiotensin II receptor antagonists

Journal of Medicinal Chemistry, 1992
The discovery of the nonpeptide angiotensin II (AII) receptor antagonist losartan, previously called DuP 753, has stimulated considerable interest in the synthesis of novel analogs of this compound. Our efforts in this area have resulted in the discovery of dihydropyrimidines as potent AII receptor antagonists. The chemistry leading to this novel class
K S, Atwal, S Z, Ahmed, J E, Bird, C L, Delaney, K E, Dickinson, F N, Ferrara, A, Hedberg, A V, Miller, S, Moreland, B C, O'Reilly   +9 more
openaire   +2 more sources

Nonpeptide angiotensin II receptor antagonists

Trends in Pharmacological Sciences, 1991
Substantial progress has been made recently in the development of nonpeptide angiotensin II receptor antagonists, a goal that has long remained an unmet challenge. Pieter Timmermans and colleagues review the pharmacology and the course of events that led to the identification of the lead compound and clinical candidate DuP753. Nonpeptide angiotensin II
P B, Timmermans, P C, Wong, A T, Chiu, W F, Herblin   +3 more
openaire   +2 more sources

Angiotensin II Receptors

1995
The renin-angiotensin system (RAS) profoundly influences cardiovascular function. The system likely evolved to meet the need to preserve cardiovascular function in response to stressors such as hemorrhage, dehydration and dietary sodium deficiency.
Robert C. Speth, Steven M. Thompson, Susan J. Johns   +2 more
openaire   +1 more source